1. Pereira B, Le Borgne M, Chartier NT, Billaud M, Almeida R

MEX-3 proteins: recent insights on novel post-transcriptional regulators. Trends in biochemical sciences 38: 477-9, 2013.  [Editorial Material] 

 doi: 10.1016/j.tibs.2013.08.004 PMID: 23999169.

 

2. Pinto R, Hansen L, Hintze J, Almeida R, Larsen S, Coskun M, Davidsen J, Mitchelmore C, David L, Troelsen JT, Bennett EP

Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression. Nucleic acids research 45: e123, 2017.  [Article] 

 doi: 10.1093/nar/gkx371 PMID: 28472465.

 

3. Barros R, da Costa LT, Pinto-de-Sousa J, Duluc I, Freund JN, David L, Almeida R

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut 60: 290-8, 2011.  [Article] 

 doi: 10.1136/gut.2010.222323 PMID: 21148572.

 

4. Barros R, Freund JN, David L, Almeida R

Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in molecular medicine 18: 555-63, 2012.  [Review] 

 doi: 10.1016/j.molmed.2012.07.006 PMID: 22871898.

 

5. Pereira B, Sousa S, Barros R, Carreto L, Oliveira P, Oliveira C, Chartier NT, Plateroti M, Rouault JP, Freund JN, Billaud M, Almeida R

CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness. Nucleic acids research 41: 3986-99, 2013.  [Article] 

 doi: 10.1093/nar/gkt087 PMID: 23408853.

 

6. Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA

Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen. Cancer research 64: 7050-7, 2004.  [Article] 

 doi: 10.1158/0008-5472.CAN-04-1921 PMID: 15466199.

 

7. Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, Van Seuningen I, David L

Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. The Journal of biological chemistry 278: 51549-56, 2003.  [Article] 

 doi: 10.1074/jbc.M309019200 PMID: 14525978.

 

8. Almeida R, Almeida J, Shoshkes M, Mendes N, Mesquita P, Silva E, Van Seuningen I, Reis CA, Santos-Silva F, David L

OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells. The Journal of pathology 207: 396-401, 2005.  [Article] 

 doi: 10.1002/path.1861 PMID: 16278805.

 

9. Camilo V, Barros R, Sousa S, Magalhães AM, Lopes T, Mário Santos A, Pereira T, Figueiredo C, David L, Almeida R

Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. Carcinogenesis 33: 1985-92, 2012.  [Article] 

 doi: 10.1093/carcin/bgs233 PMID: 22791809.

 

10. Ricardo S, Marcos-Silva L, Pereira D, Pinto R, Almeida R, Söderberg O, Mandel U, Clausen H, Felix A, Lunet N, David L

Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours. Molecular oncology 9: 503-12, 2015.  [Article] 

 doi: 10.1016/j.molonc.2014.10.005 PMID: 25454345.

 

11. Bruun J, Sveen A, Barros R, Eide PW, Eilertsen I, Kolberg M, Pellinen T, David L, Svindland A, Kallioniemi O, Guren MG, Nesbakken A, Almeida R, Lothe RA

Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer. Molecular oncology 12: 1639-1655, 2018.  [Article] 

 doi: 10.1002/1878-0261.12347 PMID: 29900672.

 

12. Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Bankovic J, Banovic B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R

Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA biology 15: 829-831, 2018.  [Editorial Material] 

 doi: 10.1080/15476286.2018.1460996 PMID: 29671387.

 

13. Tsai MH, Lin X, Shumilov A, Bernhardt K, Feederle R, Poirey R, Kopp-Schneider A, Pereira B, Almeida R, Delecluse HJ

The biological properties of different Epstein-Barr virus strains explain their association with various types of cancers. Oncotarget 8: 10238-10254, 2017.  [Article] 

 doi: 10.18632/oncotarget.14380 PMID: 28052012.

 

14. Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. The Journal of pathology 215: 411-20, 2008.  [Article] 

 doi: 10.1002/path.2369 PMID: 18498120.

 

15. Carvalho AS, Harduin-Lepers A, Magalhães A, Machado E, Mendes N, Costa LT, Matthiesen R, Almeida R, Costa J, Reis CA

Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells. The international journal of biochemistry & cell biology 42: 80-9, 2010.  [Article] 

 doi: 10.1016/j.biocel.2009.09.010 PMID: 19781661.

 

16. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolós C, David L

Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. The Journal of pathology 199: 36-40, 2003.  [Article] 

 doi: 10.1002/path.1246 PMID: 12474224.

 

17. Pinto R, Carvalho AS, Conze T, Magalhães A, Picco G, Burchell JM, Taylor-Papadimitriou J, Reis CA, Almeida R, Mandel U, Clausen H, Söderberg O, David L

Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation. Journal of cellular and molecular medicine 16: 1474-84, 2012.  [Article] 

 doi: 10.1111/j.1582-4934.2011.01436.x PMID: 21883895.

 

18. Pereira B, Oliveira C, David L, Almeida R

CDX2 promoter methylation is not associated with mRNA expression. International journal of cancer 125: 1739-42, 2009.  [Letter] 

 doi: 10.1002/ijc.24544 PMID: 19569237.

 

19. Mesquita P, Almeida R, Van Seuningen I, David L

Coordinated expression of MUC2 and CDX-2 in mucinous carcinomas of the lung can be explained by the role of CDX-2 as transcriptional regulator of MUC2. The American journal of surgical pathology 28: 1254-5, 2004.  [Letter] 

 PMID: 15316331.

 

20. Serpa J, Mendes N, Reis CA, Santos Silva LF, Almeida R, Le Pendu J, David L

Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G-->A and 839T-->C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal. The Biochemical journal 383: 469-74, 2004.  [Article] 

 doi: 10.1042/BJ20040803 PMID: 15250822.

 

21. Oliveira P, Carvalho J, Rocha S, Azevedo M, Reis I, Camilo V, Sousa B, Valente S, Paredes J, Almeida R, Huntsman D, Oliveira C

Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation. Scientific reports 6: 34860, 2016.  [Article] 

 doi: 10.1038/srep34860 PMID: 27721458.

 

22. Pinto R, Barros R, Pereira-Castro I, Mesquita P, da Costa LT, Bennett EP, Almeida R, David L

CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia. Laboratory investigation; a journal of technical methods and pathology 95: 718-27, 2015.  [Article] 

 doi: 10.1038/labinvest.2015.52 PMID: 25867765.

 

23. Sadio A, Amaral AL, Nunes R, Ricardo S, Sarmento B, Almeida R, Tsukamoto H, das Neves J

A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution. Frontiers in physiology 7: 579, 2016.  [Article] 

 doi: 10.3389/fphys.2016.00579 PMID: 27965585.

 

24. Barros R, Camilo V, Pereira B, Freund JN, David L, Almeida R

Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation. Biochemical Society transactions 38: 358-63, 2010.  [Article; Proceedings Paper] 

 doi: 10.1042/BST0380358 PMID: 20298183.

 

25. Conze T, Carvalho AS, Landegren U, Almeida R, Reis CA, David L, Söderberg O

MUC2 mucin is a major carrier of the cancer-associated sialyl-Tn antigen in intestinal metaplasia and gastric carcinomas. Glycobiology 20: 199-206, 2010.  [Article] 

 doi: 10.1093/glycob/cwp161 PMID: 19815850.

 

26. Silva F, Carvalho F, Peixoto A, Teixeira A, Almeida R, Reis C, Bravo LE, Realpe L, Correa P, David L

MUC1 polymorphism confers increased risk for intestinal metaplasia in a Colombian population with chronic gastritis. European journal of human genetics : EJHG 11: 380-4, 2003.  [Article] 

 doi: 10.1038/sj.ejhg.5200978 PMID: 12734543.

 

27. Santos-Silva F, Fonseca A, Caffrey T, Carvalho F, Mesquita P, Reis C, Almeida R, David L, Hollingsworth MA

Thomsen-Friedenreich antigen expression in gastric carcinomas is associated with MUC1 mucin VNTR polymorphism. Glycobiology 15: 511-7, 2005.  [Article] 

 doi: 10.1093/glycob/cwi027 PMID: 15604091.

 

28. Camilo V, Garrido M, Valente P, Ricardo S, Amaral AL, Barros R, Chaves P, Carneiro F, David L, Almeida R

Differentiation reprogramming in gastric intestinal metaplasia and dysplasia: role of SOX2 and CDX2. Histopathology 66: 343-50, 2015.  [Article] 

 doi: 10.1111/his.12544 PMID: 25196071.

 

29. Mesquita P, Raquel A, Nuno L, Reis CA, Silva LF, Serpa J, Van Seuningen I, Barros H, David L

Metaplasia--a transdifferentiation process that facilitates cancer development: the model of gastric intestinal metaplasia. Critical reviews in oncogenesis 12: 3-26, 2006.  [] 

 PMID: 17078204.

 

30. Camilo V, Barros R, Celestino R, Castro P, Vieira J, Teixeira MR, Carneiro F, Pinto-de-Sousa J, David L, Almeida R

Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome. BMC cancer 14: 753, 2014.  [Article] 

 doi: 10.1186/1471-2407-14-753 PMID: 25300947.

 

31. Serpa J, Mesquita P, Mendes N, Oliveira C, Almeida R, Santos-Silva F, Reis CA, LePendu J, David L

Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation. Cancer letters 242: 191-7, 2006.  [Article] 

 doi: 10.1016/j.canlet.2005.11.009 PMID: 16427187.

 

32. Sadio A, Gustafsson JK, Pereira B, Gomes CP, Hansson GC, David L, Pêgo AP, Almeida R

Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrier. PloS one 9: e99449, 2014.  [Article] 

 doi: 10.1371/journal.pone.0099449 PMID: 24925340.

 

33. Silva F, Carvalho F, Peixoto A, Seixas M, Almeida R, Carneiro F, Mesquita P, Figueiredo C, Nogueira C, Swallow DM, Amorim A, David L

MUC1 gene polymorphism in the gastric carcinogenesis pathway. European journal of human genetics : EJHG 9: 548-52, 2001.  [Article] 

 doi: 10.1038/sj.ejhg.5200677 PMID: 11464247.

 

34. Barros R, Mendes N, Howe JR, Reis CA, de Bolos C, Carneiro F, David L, Almeida R

Juvenile polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4. Histochemistry and cell biology 131: 765-72, 2009.  [Article] 

 doi: 10.1007/s00418-009-0579-z PMID: 19266212.

 

35. Peleteiro B, Lunet N, Wen X, Afonso LP, Mendes N, Barros R, Carneiro F, Almeida R, Barros H

Association between environmental factors and CDX2 expression in gastric cancer patients. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 21: 423-31, 2012.  [Review] 

 doi: 10.1097/CEJ.0b013e32834ef1aa PMID: 22157086.

 

36. Peleteiro B, Barros R, Carrilho C, Artiaga J, Cunha L, Modcoicar P, Ferreira R, Figueiredo C, Almeida R, La Vecchia C, David L, Barros H, Lunet N

Determinants of gastric CDX2 expression: a study in Mozambique. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 21: 532-540, 2012.  [Article] 

 doi: 10.1097/CEJ.0b013e3283523480 PMID: 22407102.

 

37. Peleteiro B, Carrilho C, Modcoicar P, Cunha L, Ismail M, Guisseve A, Lorenzoni C, Fernandes F, Almeida R, Figueiredo C, David L

Chronic Atrophic Gastritis, Intestinal Metaplasia, Helicobacter pylori Virulence, IL1RN Polymorphisms, and Smoking in Dyspeptic Patients from Mozambique and Portugal Helicobacter 14: 306-308, 2009.  [Letter] 

.

 

38. Camilo V, Barros R, Pereira B, Magalhaes A, Reis C, Freund J, David L, David L, Almeida R

BMP and H-pylori Downregulate SOX2 Expression in Gastric Cell Lines Helicobacter 14: 330-330, 2009.  [Meeting Abstract] 

.

 

39. Pereira B, Oliveira C, David L, Almeida R

CDX2 Promoter Methylation is not Associated with mRNA Expression Helicobacter 14: 385-385, 2009.  [Meeting Abstract] 

.

 

40. Gomes J, Marcos NT, Berois N, Osinaga E, Magalhães A, Pinto-de-Sousa J, Almeida R, Gärtner F, Reis CA

Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 57: 79-86, 2009.  [Article] 

 doi: 10.1369/jhc.2008.952283 PMID: 18854599.

 

41. Silva LM, Carvalho AS, Guillon P, Seixas S, Azevedo M, Almeida R, Ruvoën-Clouet N, Reis CA, Le Pendu J, Rocha J, David L

Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies. Glycoconjugate journal 27: 61-8, 2010.  [Article] 

 doi: 10.1007/s10719-009-9255-8 PMID: 19757028.

 

42. Mesquita P, Peixoto AJ, Seruca R, Hanski C, Almeida R, Silva F, Reis C, David L

Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas. Cancer letters 189: 129-36, 2003.  [Article] 

 PMID: 12490305.

 

43. Amado M, Almeida R, Schwientek T, Clausen H

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochimica et biophysica acta 1473: 35-53, 1999.  [Review] 

 PMID: 10580128.

 

44. Marcos NT, Cruz A, Silva F, Almeida R, David L, Mandel U, Clausen H, Von Mensdorff-Pouilly S, Reis CA

Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 51: 761-71, 2003.  [Article] 

 PMID: 12754287.

 

45. Barros R, Pereira D, Callé C, Camilo V, Cunha AI, David L, Almeida R, Dias-Pereira A, Chaves P

Dynamics of SOX2 and CDX2 Expression in Barrett's Mucosa. Disease markers 2016: 1532791, 2016.  [Article] 

 doi: 10.1155/2016/1532791 PMID: 27766003.

 

46. Serpa J, Almeida R, Oliveira C, Silva FS, Silva E, Reis C, Le Pendu J, Oliveira G, Ribeiro LM, David L

Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population. Journal of human genetics 48: 183-9, 2003.  [Article] 

 doi: 10.1007/s10038-003-0007-5 PMID: 12730721.

 

47. Barros R, Marcos N, Reis CA, De Luca A, David L, Almeida R

CDX2 expression is induced by Helicobacter pylori in AGS cells. Scandinavian journal of gastroenterology 44: 124-5, 2009.  [Letter] 

 doi: 10.1080/00365520802530846 PMID: 18991163.

 

48. Rodrigues JP, David L, Almeida R, Barros R, Freitas T, Silva J, Ponte A, Sousa M, Silva JC, Carvalho J

Mechanisms of regulation of normal and metaplastic intestinal differentiation. Histology and histopathology 33: 523-532, 2018.  [Review] 

 doi: 10.14670/HH-11-938 PMID: 29027178.

 

49. Barros R, Peleteiro B, Almeida R, Figueiredo C, Barros H, David L, Lunet N

Relevance of high virulence Helicobacter pylori strains and futility of CDX2 expression for predicting intestinal metaplasia after eradication of infection. Scandinavian journal of gastroenterology 45: 828-34, 2010.  [Article] 

 doi: 10.3109/00365521003770269 PMID: 20367284.

 

50. Botelho MC, Soares R, Vale N, Ribeiro R, Camilo V, Almeida R, Medeiros R, Gomes P, Machado JC, Correia da Costa JM

Schistosoma haematobium: identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate estrogen receptor in mammalian cells. Experimental parasitology 126: 526-35, 2010.  [Article] 

 doi: 10.1016/j.exppara.2010.06.012 PMID: 20547157.

 

51. Sousa AM, Grandgenett PM, David L, Almeida R, Hollingsworth MA, Santos-Silva F

Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 124: 913-924, 2016.  [Review] 

 doi: 10.1111/apm.12587 PMID: 27538373.

 

52. Rolim I, Rodrigues RV, Bettencourt A, Barros R, Camilo V, Dias Pereira A, Almeida R, Chaves P

Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway? International journal of surgical pathology 25: 262-265, 2017.  [Article] 

 doi: 10.1177/1066896916672332 PMID: 27708180.

 

53. Pinto-de-Sousa J, David L, Almeida R, Leitão D, Preto JR, Seixas M, Pimenta A

c-erb B-2 expression is associated with tumor location and venous invasion and influences survival of patients with gastric carcinoma. International journal of surgical pathology 10: 247-56, 2002.  [Article] 

 PMID: 12490974.

 

54. Almeida R, Levery SB, Mandel U, Kresse H, Schwientek T, Bennett EP, Clausen H

Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family. The Journal of biological chemistry 274: 26165-71, 1999.  [Article] 

 PMID: 10473568.

 

55. Pereira B, Billaud M, Almeida R

RNA-Binding Proteins in Cancer: Old Players and New Actors. Trends in cancer 3: 506-528, 2017.  [Review] 

 doi: 10.1016/j.trecan.2017.05.003 PMID: 28718405.