Ipatimup

RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH

José Manuel Lopes

Name: José Manuel Lopes

E-mail: jmlopes@ipatimup.pt

Extension:

225570700

José Manuel Lopes

Member of

Consultant of Ipatimup Diagnostics

Researcher of Cancer Signalling & Metabolism

Short CV

José Manuel Lopes, MD, Ph.D., IFCAP, is an Associate Professor of Pathology (Medical Faculty of Porto University), Chief Pathologist of the Department of Anatomic Pathology (Centro Hospitalar Universitário São João), Senior Researcher of I3S, and Senior Consultant at IPATIMUP Diagnósticos. He is a co-author of 300 peer-reviewed publications (h-index: 44) and five chapters of books. His specialization is bone/soft tissue, neuroendocrine, neuropathology, dermatopathology, and urogenital pathology. His research is understanding the pathogenesis and molecular pathology of melanomas, cutaneous, soft tissue, urogenital, and neuroendocrine tumors.

Highlights

Molecular Pathology: Gists, GEP-NETs and Melanomas

PI (closed)

Study of mTOR pathway in GISTs

Instalação de uma base de dados e banco de tecidos de tumores estromais gastrointestinais e tumores neuroendócrinos (Regist e REGENE)

Tumores Estrumais Gastrointestinais: Caracterização Clinico-Patológica e Imuno-Histoquímica e Identificação de Factores de Agressividade Biológica

Is the mTOR pathway relevant in the initiation/progression and/or a putative therapeutic target in melanomas?

First Author

1. Lopes JM, Nesland JM, Reis-Filho JS, Holm R

Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin. Histopathology 40: 464-71, 2002. [Article]

PMID: 12010367.

2.9

2. Lopes JM, Hannisdal E, Bjerkehagen B, Bruland OS, Danielsen HE, Pettersen EO, Sobrinho-Simões M, Nesland JM

Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 16: 45-62, 1998. [Article]

PMID: 9584899.

3. Lopes JM, Silva P, Seixas M, Cirnes L, Seruca R

Microsatellite instability is not associated with degree of malignancy and p53 expression of gastrointestinal stromal tumours. Histopathology 33: 579-81, 1998. [Letter]

PMID: 9870157.

1.7

4. Lopes JM, Bruland OS, Bjerkehagen B, Silva MC, Holm R, Pettersen EO, Solheim OP, Sobrinho-Simões M, Nesland JM

Synovial sarcoma: immunohistochemical expression of P-glycoprotein and glutathione S transferase-pi and clinical drug resistance. Pathology, research and practice 193: 21-36, 1997. [Review]

PMID: 9112270.

5. Lopes JM

Inflammatory fibrosarcoma. Another imitator of Hodgkin's disease? Critical commentary Pathology, research and practice 192: 479–480, 1996. [Editorial Material]

doi: 10.1016/S0344-0338(96)80013-6.

6. Lopes JM

Critical Commentary to "Carcinoma Arising in Ectopic Hamartomatous Thymoma" Pathology, research and practice 192: 621, 1996. []

doi: 10.1016/S0344-0338(96)80115-4.

7. Lopes JM

Critical Commentary to "Spiradenoma Associated with Apocrine Adenoma Component" Pathology, research and practice 192: 1140–1141, 1996. []

doi: 10.1016/S0344-0338(96)80033-1.

8. Lopes JM, Bjerkehagen B, Holm R, Bruland O, Sobrinho-Simões M, Nesland JM

Proliferative activity of synovial sarcoma: an immunohistochemical evaluation of Ki-67 labeling indices of 52 primary and recurrent tumors. Ultrastructural pathology 19: 101-6, 1995. [Article]

PMID: 7792946.

9. Lopes JM, Bjerkehagen B, Holm R, Bruland O, Sobrinho-Simões M, Nesland JM

Immunohistochemical profile of synovial sarcoma with emphasis on the epithelial-type differentiation. A study of 49 primary tumours, recurrences and metastases. Pathology, research and practice 190: 168-77, 1994. [Article]

PMID: 7520165.

10. Lopes JM

POLYCYSTIC TUMOR OF THE ATRIOVENTRICULAR NODAL REGION IN A MAN WITH EMERY-DREYFUSS MUSCULAR-DYSTROPHY - COMMENTARY Pathology, research and practice 189: 965-966, 1993. [Editorial Material]

doi: 10.1016/S0344-0338(11)81114-3.

11. Lopes JM, Seruca R, Sobrinho-Simões M

Critical Commentary Pathology, research and practice 189: 473-474, 1993. [Editorial Material]

doi: 10.1016/S0344-0338(11)80341-9.

12. Lopes JM, Seruca R, Soares P, Castro-Correia J, Castedo S

Adenoma of the ciliary body- A pathologic and cytogenetic study Cancer genetics and cytogenetics 63: 177, 1992. []

doi: 10.1016/0165-4608(92)90531-C.

13. Lopes JM, Paiva ME

Malignant primitive neuroepithelial tumour of soft tissues mimicking a cellular ependymoma. Pathologica 84: 67-76, 1992. []

PMID: 1495851.

Senior Author

1. Castanheira A, Boaventura P, Pais Clemente M, Soares P, Mota A, Lopes JM

Head and neck cutaneous basal cell carcinoma: what should the otorhinolaryngology head and neck surgeon care about? Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 40: 5-18, 2020. [Review]

doi: 10.14639/0392-100X-2245 PMID: 31388193.

1.5 (*)

2. Vinagre J, Pinheiro J, Martinho O, Reis RM, Preto J, Soares P, Lopes JM

A 30-Year Long-Term Experience in Appendix Neuroendocrine Neoplasms-Granting a Positive Outcome. Cancers 12: ., 2020. [Article]

doi: 10.3390/cancers12061357 PMID: 32466539.

6.1 (*)

3. Silva C, Pires-Luís AS, Rocha E, Bartosch C, Lopes JM

Phenotypic Intratumoral Heterogeneity of Endometrial Carcinomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 37: 154-166, 2018. [Article]

doi: 10.1097/PGP.0000000000000400 PMID: 28582348.

1.6 (*)

4. Duarte TL, Caldas C, Santos AG, Silva-Gomes S, Santos-Gonçalves A, Martins MJ, Porto G, Lopes JM

Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis. Redox biology 11: 157-169, 2017. [Article]

doi: 10.1016/j.redox.2016.11.013 PMID: 27936457.

7.1

5. Bartosch C, Afonso M, Pires-Luís AS, Galaghar A, Guimarães M, Antunes L, Lopes JM

Distant Metastases in Uterine Leiomyosarcomas: The Wide Variety of Body Sites and Time Intervals to Metastatic Relapse. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 36: 31-41, 2017. [Article]

doi: 10.1097/PGP.0000000000000284 PMID: 27015437.

1.6

6. Bartosch C, Pires M, Jerónimo C, Lopes JM

The role of pathology in the management of patients with endometrial carcinoma. Future oncology (London, England) 13: 1003-1020, 2017. [Review]

doi: 10.2217/fon-2016-0570 PMID: 28481146.

2.4

7. Barroca HM, Cirnes L, Lopes JM

Metanephric adenoma: Cytological, histological, and molecular diagnosis of a case. Diagnostic cytopathology 44: 263-6, 2016. [Letter]

doi: 10.1002/dc.23427 PMID: 26800350.

1.2

8. Bartosch C, Monteiro-Reis S, Vieira R, Pereira A, Rodrigues M, Jerónimo C, Lopes JM

Endometrial Endometrioid Carcinoma Metastases Show Decreased ER-Alpha and PR-A Expression Compared to Matched Primary Tumors. PloS one 10: e0134969, 2015. [Article]

doi: 10.1371/journal.pone.0134969 PMID: 26252518.

3.1

9. Bartosch C, Gomes B, Jerónimo C, Lopes JM

Endometrial carcinoma in Portugal: demographic, diagnostic and treatment changes in the last 5 decades. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 34: 159-68, 2015. [Article]

doi: 10.1097/PGP.0000000000000124 PMID: 25675186.

1.4

10. de Beça FF, Lopes J, Maçoas F, Carneiro F, Lopes JM

Tactoid body features in a Schwann cell hamartoma of colonic mucosa. International journal of surgical pathology 22: 438-41, 2014. [Article]

doi: 10.1177/1066896913501384 PMID: 23994879.

1.0

11. Celestino R, Lima J, Faustino A, Vinagre J, Máximo V, Gouveia A, Soares P, Lopes JM

Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors. European journal of human genetics : EJHG 21: 503-10, 2013. [Article]

doi: 10.1038/ejhg.2012.205 PMID: 22948025.

4.2

12. Barroca H, Lopes JM

Feasibility of fine-needle aspiration in the diagnosis of two unusual childhood jaw tumor types: prognoma and cementifying fibroma. Acta cytologica 57: 107-12, 2013. [Article]

doi: 10.1159/000343890 PMID: 23220889.

1.6

13. Caplin M, Sundin A, Nillson O, Baum RP, Klose KJ, Kelestimur F, Plöckinger U, Papotti M, Salazar R, Pascher A, Lopes JM

ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. Neuroendocrinology 95: 88-97, 2012. [Article]

doi: 10.1159/000335594 PMID: 22261972.

177

3.5

14. Pópulo H, Soares P, Lopes JM

Insights into melanoma: targeting the mTOR pathway for therapeutics. Expert opinion on therapeutic targets 16: 689-705, 2012. [Review]

doi: 10.1517/14728222.2012.691472 PMID: 22620498.

4.1

15. Celestino R, Lima J, Faustino A, Máximo V, Gouveia A, Vinagre J, Soares P, Lopes JM

A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney-Stratakis dyad. Familial cancer 11: 189-94, 2012. [Article]

doi: 10.1007/s10689-011-9499-x PMID: 22160509.

1.9

16. Vala H, Pópulo H, Mesquita JR, Esteves F, Santos C, Soares P, Lopes JM

Melanocytic tumour in a black sheep never exposed to ultraviolet radiation. Journal of comparative pathology 146: 160-4, 2012. [Article]

doi: 10.1016/j.jcpa.2011.04.001 PMID: 21612790.

1.4

17. Pópulo H, Soares P, Faustino A, Rocha AS, Silva P, Azevedo F, Lopes JM

mTOR pathway activation in cutaneous melanoma is associated with poorer prognosis characteristics. Pigment cell & melanoma research 24: 254-7, 2011. [Letter]

doi: 10.1111/j.1755-148X.2010.00796.x PMID: 21029395.

5.1

18. Bartosch C, Vieira J, Teixeira MR, Lopes JM

Endometrial endometrioid adenocarcinoma associated with primitive neuroectodermal tumour of the uterus: a poor prognostic subtype of uterine tumours. Medical oncology (Northwood, London, England) 28: 1488-94, 2011. [Article]

doi: 10.1007/s12032-010-9579-z PMID: 20512430.

2.1

19. Pópulo H, Soares P, Rocha AS, Silva P, Lopes JM

Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma. Melanoma research 20: 107-17, 2010. [Article]

doi: 10.1097/CMR.0b013e32832ccd09 PMID: 20173664.

2.3

20. Kos-Kudla B, O'Toole D, Falconi M, Gross D, Klöppel G, Sundin A, Ramage J, Oberg K, Wiedenmann B, Komminoth P, Van Custem E, Mallath M, Papotti M, Caplin M, Collaborators, including Lopes JM .

ENETS consensus guidelines for the management of bone and lung metastases from neuroendocrine tumors. Neuroendocrinology 91: 341-50, 2010. [Article]

doi: 10.1159/000287255 PMID: 20484875.

3.3

21. Kianmanesh R, Ruszniewski P, Rindi G, Kwekkeboom D, Pape UF, Kulke M, Sevilla Garcia I, Scoazec JY, Nilsson O, Fazio N, Lesurtel M, Chen YJ, Eriksson B, Cioppi F, O'Toole D, Collaborators, including Lopes JM .

ENETS consensus guidelines for the management of peritoneal carcinomatosis from neuroendocrine tumors. Neuroendocrinology 91: 333-40, 2010. [Article]

doi: 10.1159/000286700 PMID: 20424420.

3.3

22. Bartosch C, Exposito MI, Lopes JM

Low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma: a comparative analysis emphasizing the importance of distinguishing between these two groups. International journal of surgical pathology 18: 286-91, 2010. [Article]

doi: 10.1177/1066896909337600 PMID: 19482859.

1.1

23. O'Toole D, Rindi G, Plöckinger U, Wiedenmann B, Collaborators, including Lopes JM

ENETS consensus guidelines for the management of patients with rare metastases from digestive neuroendocrine tumors: rationale and working framework. Introduction. Neuroendocrinology 91: 324-5, 2010. [Editorial Material]

doi: 10.1159/000287272 PMID: 20407213.

3.3

24. Martinho O, Gouveia A, Silva P, Pimenta A, Reis RM, Lopes JM

Loss of RKIP expression is associated with poor survival in GISTs. Virchows Archiv : an international journal of pathology 455: 277-84, 2009. [Article]

doi: 10.1007/s00428-009-0821-z PMID: 19705153.

2.3

25. Martinho O, Gouveia A, Viana-Pereira M, Silva P, Pimenta A, Reis RM, Lopes JM

Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs. Histopathology 55: 53-62, 2009. [Article]

doi: 10.1111/j.1365-2559.2009.03323.x PMID: 19614767.

3.9

26. Eriksson B, Klöppel G, Krenning E, Ahlman H, Plöckinger U, Wiedenmann B, Arnold R, Auernhammer C, Körner M, Rindi G, Wildi S, Conference participants Frascati Consensus

Consensus guidelines for the management of patients with digestive neuroendocrine tumors--well-differentiated jejunal-ileal tumor/carcinoma. Neuroendocrinology 87: 8-19, 2008. [Article; Proceedings Paper]

doi: 10.1159/000111034 PMID: 18097129.

181

2.9

27. Plöckinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, de Herder WW, Gross D, Knapp WH, Knigge UP, Kulke MH, Pape UF, Frascati Consensus Conference participants, including Lopes JM

Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology 87: 20-30, 2008. [Article; Proceedings Paper]

doi: 10.1159/000109876 PMID: 17934252.

2.9

28. Ramage JK, Goretzki PE, Manfredi R, Komminoth P, Ferone D, Hyrdel R, Kaltsas G, Kelestimur F, Kvols L, Scoazec JY, Garcia MI, Caplin ME, Frascati Consensus Conference participants, including Lopes JM

Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated colon and rectum tumour/carcinoma. Neuroendocrinology 87: 31-9, 2008. [Article; Proceedings Paper]

doi: 10.1159/000111036 PMID: 18097130.

2.9

29. Ahlman H, Nilsson O, McNicol AM, Ruszniewski P, Niederle B, Ricke J, Jensen R, Kos-Kudla B, Oberg K, O'Connor JM, Pavel ME, Vullierme MP, Conference participants Frascati Consensus

Poorly-differentiated endocrine carcinomas of midgut and hindgut origin. Neuroendocrinology 87: 40-6, 2008. [Article; Proceedings Paper]

doi: 10.1159/000109976 PMID: 17940332.

2.9

30. Gouveia AM, Pimenta AP, Capelinha AF, de la Cruz D, Silva P, Lopes JM

Surgical margin status and prognosis of gastrointestinal stromal tumor. World journal of surgery 32: 2375-82, 2008. [Article]

doi: 10.1007/s00268-008-9704-8 PMID: 18685890.

2.6

31. Gomes AL, Gouveia A, Capelinha AF, de la Cruz D, Silva P, Reis RM, Pimenta A, Lopes JM

Molecular alterations of KIT and PDGFRA in GISTs: evaluation of a Portuguese series. Journal of clinical pathology 61: 203-8, 2008. [Article]

doi: 10.1136/jcp.2007.047043 PMID: 17827398.

2.3

32. Barroca H, Farinha NJ, Lobo A, Monteiro J, Lopes JM

Deep-seated congenital juvenile xanthogranuloma: report of a case with emphasis on cytologic features. Acta cytologica 51: 473-6, 2007. [Article]

PMID: 17536559.

0.7

33. Gouveia A, Pimenta A, Lopes JM

Quando e como operar os tumours estromais gastrointestinais primários. Revista Portuguesa de Cirurgia 1: 49-52, 2007. []

34. Reis RM, Reis-Filho JS, Longatto Filho A, Tomarev S, Silva P, Lopes JM

Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors. Pathology, research and practice 201: 771-6, 2005. [Article]

doi: 10.1016/j.prp.2005.08.010 PMID: 16308102.

1.0

35. Reis RM, Martins A, Ribeiro SA, Basto D, Longatto-Filho A, Schmitt FC, Lopes JM

Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas. Cellular oncology : the official journal of the International Society for Cellular Oncology 27: 319-26, 2005. [Article]

PMID: 16373964.

4.2

36. Veloso FT, Pereira P, Saraiva A, Capelinha AF, Lopes JM

Colonic gastrointestinal autonomic nervous tumor in a patient with Crohn's disease. Digestive diseases and sciences 50: 1476-80, 2005. [Article]

PMID: 16110839.

1.4

37. Reis-Filho JS, Paiva ME, Lopes JM

August 2003: 47-year-old female with a 7-year history of osteomalacia and hypophosphatemia. Brain pathology (Zurich, Switzerland) 14: 111-2, 115, 2004. [Article]

PMID: 14997944.

4.0

38. Cruz J, Reis-Filho JS, Lopes JM

Malignant peripheral nerve sheath tumour-like primary cutaneous malignant melanoma. Journal of clinical pathology 57: 218-20, 2004. [Article]

PMID: 14747458.

2.6

39. Cruz J, Reis-Filho JS, Silva P, Lopes JM

Expression of c-met tyrosine kinase receptor is biologically and prognostically relevant for primary cutaneous malignant melanomas. Oncology 65: 72-82, 2003. [Article]

doi: 10.1159/000071207 PMID: 12837985.

2.4

40. Cruz J, Reis-Filho JS, Lopes JM

Primary cutaneous malignant melanoma with lipoblast-like cells. Archives of pathology & laboratory medicine 127: 370-1, 2003. [Editorial Material]

PMID: 12653588.

1.3

41. Reis-Filho JS, Lopes JM

Pathologic quiz case: a 53-year-old man with a slowly enlarging mass in the right leg. Archives of pathology & laboratory medicine 127: 627-8, 2003. [Editorial Material]

PMID: 12708914.

1.3

42. Cruz J, Reis-Filho JS, Lopes JM

Cutaneous malignant melanoma: the great simulator. International journal of surgical pathology 11: 35, 2003. [Article]

PMID: 12598916.

1.0

43. Reis-Filho JS, Paiva ME, Lopes JM

Congenital composite hemangioendothelioma: case report and reappraisal of the hemangioendothelioma spectrum. Journal of cutaneous pathology 29: 226-31, 2002. [Article]

PMID: 12028155.

1.3

44. Reis-Filho JS, Souto-Moura C, Lopes JM

Classic Kaposi's sarcoma of the tongue: case report with emphasis on the differential diagnosis. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 60: 951-4, 2002. [Editorial Material]

PMID: 12149747.

0.9

45. Reis-Filho JS, Paiva ME, Lopes JM

Pathologic quiz case. A 36-year-old woman with muscle pain and weakness. Phosphaturic mesenchymal tumor (mixed connective tissue variant)/oncogenic osteomalacia. Archives of pathology & laboratory medicine 126: 1245-6, 2002. [Editorial Material]

PMID: 12385334.

1.4

46. Reis-Filho JS, Silva P, Milanezi F, Lopes JM

Hyaline cell-rich chondroid syringoma: case report and review of the literature. Pathology, research and practice 198: 755-64, 2002. [Article]

PMID: 12530579.

0.9

47. Cruz D, Melo N, Seixas M, Lopes JM

Measuring beyond the microscope field of view using digital images in squamous cell carcinoma of the lip. Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 23: 245-50, 2001. [Article]

PMID: 11531138.

0.7

48. Schmitt FC, Ribeiro CA, Alvarenga S, Lopes JM

Primary acinic cell-like carcinoma of the breast--a variant with good prognosis? Histopathology 36: 286-9, 2000. [Letter]

PMID: 10809602.

2.6

49. Lopes JM

Critical Commentary to "Carcinoma Arising in Ectopic Hamartomatous Thymoma" Pathology, research and practice 192: 621, 1996. []

doi: 10.1016/S0344-0338(96)80115-4.

50. Lopes JM

Critical Commentary to "Spiradenoma Associated with Apocrine Adenoma Component" Pathology, research and practice 192: 1140–1141, 1996. []

doi: 10.1016/S0344-0338(96)80033-1.

@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto