RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH
 
Valdemar Máximo
Name: Valdemar Máximo
E-mail: vmaximo@ipatimup.pt
Extension: 
225570700
Academic Degree: PhD


Valdemar Máximo
Valdemar Máximo
Member of
Researcher of Cancer Signalling & Metabolism


Short CV

Valdemar Máximo (VM) graduated in Biology in 1994 in Coimbra University where he continued as a Master student, in 1995/1996 studying the role of mitochondrial dysfunction in schizophrenia. VM did his PhD in 2001 at the Faculty of Medicine of the University of Porto (FMUP) in a project developed at Ipatimup and Ludwig-Maximilians-University Munich. Due to his expertise in mitochondria, VM introduced at Ipatimup the interest on the role played by mitochondrial abnormalities in cancer. As a Post-doc he continued focusing his research on this topic, clarifying the role mtDNA abnormalities in tumor development leading to his recognition as an international reference scientist in the field. In 2007, VM was hired as a Ciência 2007 researcher at Ipatimup and since then he built a research team focusing on one of the hottest areas of cancer research ? cancer metabolism. VM has supervised MSc and PhD students as well as Post-docs. Presently, VM is a PI of a team studying ? Cancer as a metabolic disease. VM is an Auxiliary Professor of Biopathology at the FMUP. He has published 94 peer-reviewed papers, with over 5.565 citations by other authors and with an h-index of 35.

Highlights

Supervisor of
Mariana Gonçalves, Master Student (theoretical phase)
MSc student
Marta Cardoso, Fellow
Research Fellowship (MSc)
Miguel Castanho, Master Student (theoretical phase)
MSc student
Nuno Jesus, PhD Student
PhD student

PI (running)
Study the relevance of superoxide dismutase 2 in thyroid cancer

PI (closed)
ROle of the MITOchondrial fission protein Drp1 as a prognosis and predictive biomarker in the treatment of differentiated thyroid cancer (ROMITO-DRP1)
“Novos alvos na insuficiência cardíaca diastólica: das comorbilidades à medicina personalizada”
Mapeamento de genes de susceptibilidade para tumores familiares da tireóide
GRIM-19, a novel protein involved in cell apoptosis: structure-function characterization
First Author
 
C
IF
1. Máximo V, Rios E, Sobrinho-Simões M
Oncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands. International journal of surgical pathology 22: 33-6, 2014. [Review] 
 doi: 10.1177/1066896913517938 PMID: 24406625.
 
26
1.0
2. Máximo V, Lima J, Prazeres H, Soares P, Sobrinho-Simões M
The biology and the genetics of Hurthle cell tumors of the thyroid. Endocrine-related cancer 19: R131-47, 2012. [Review] 
 doi: 10.1530/ERC-11-0354 PMID: 22514109.
 
49
5.3
3. Celestino R, Lima J, Faustino A, Máximo V, Gouveia A, Vinagre J, Soares P, Lopes JM
A novel germline SDHB mutation in a gastrointestinal stromal tumor patient without bona fide features of the Carney-Stratakis dyad. Familial cancer 11: 189-94, 2012. [Article] 
 doi: 10.1007/s10689-011-9499-x PMID: 22160509.
 
15
1.9
4. Máximo V, Lima J, Soares P, Sobrinho-Simões M
Mitochondria and cancer. Virchows Archiv : an international journal of pathology 454: 481-95, 2009. [Review] 
 doi: 10.1007/s00428-009-0766-2 PMID: 19343360.
 
40
2.3
5. Máximo V, Lima J, Soares P, Silva A, Bento I, Sobrinho-Simões M
GRIM-19 in Health and Disease. Advances in anatomic pathology 15: 46-53, 2008. [Editorial Material] 
 doi: 10.1097/PAP.0b013e31815e5258 PMID: 18156812.
 
18
3.7
6. Máximo V, Botelho T, Capela J, Soares P, Lima J, Taveira A, Amaro T, Barbosa AP, Preto A, Harach HR, Williams D, Sobrinho-Simões M
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. British journal of cancer 92: 1892-8, 2005. [Article] 
 doi: 10.1038/sj.bjc.6602547 PMID: 15841082.
 
152
4.1
7. Máximo V, Lima J, Soares P, Botelho T, Gomes L, Sobrinho-Simões M
Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy. Mitochondrion 5: 333-40, 2005. [Article] 
 doi: 10.1016/j.mito.2005.06.003 PMID: 16183030.
 
28
0.8
8. Máximo V, Preto A, Crespo A, Rocha AS, Machado JC, Soares P, Sobrinho-Simões M
Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid. BMC cancer 4: 12, 2004. [Article] 
 doi: 10.1186/1471-2407-4-12 PMID: 15043758.
 
4
2.3
9. Máximo V, Soares P, Lima J, Cameselle-Teijeiro J, Sobrinho-Simões M
Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors. The American journal of pathology 160: 1857-65, 2002. [Article] 
 PMID: 12000737.
 
192
6.8
10. Máximo V, Soares P, Seruca R, Rocha AS, Castro P, Sobrinho-Simões M
Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma. Genes, chromosomes & cancer 32: 136-43, 2001. [Article] 
 PMID: 11550281.
 
101
4.4
11. Máximo V, Sobrinho-Simões M
Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Archiv : an international journal of pathology 437: 107-15, 2000. [Review] 
 PMID: 10993269.
 
98
1.7
12. Máximo V, Sobrinho-Simões M
Mitochondrial DNA 'common' deletion in Hürthle cell lesions of the thyroid. The Journal of pathology 192: 561-2, 2000. [Letter] 
 doi: 10.1002/1096-9896(200012)192:4<561::AID-PATH790>3.0.CO;2-3 PMID: 11113879.
 
44
4.1
13. Máximo V, Soares P, Machado JC, Seruca R, Sobrinho-Simões M
Mitochondrial DNA alteration in gastric cancer. Gastroenterology 119: 1808-9, 2000. [Letter] 
 PMID: 11187439.
 
14
12.2
14. Máximo V, Soares P, Seruca R, Sobrinho-Simões M
Comments on: mutations in mitochondrial control region DNA in gastric tumours of Japanese patients, Tamura, et al. Eur J Cancer 1999, 35, 316-319. European journal of cancer (Oxford, England : 1990) 35: 1407-8, 1999. [Letter] 
 PMID: 10658535.
 
24
2.7
15. Máximo V, Sores P, Rocha AS, Sobrinho-Simões M
The common deletion of mitochondrial DNA is found in goiters and thyroid tumors with and without oxyphil cell change. Ultrastructural pathology 22: 271-3, 1998. [Letter] 
 PMID: 9793208.
 
29
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Senior Author
 
C
IF
1. Canberk S, Ferreira JC, Pereira L, Batista R, Vieira AF, Soares P, Sobrinho Simões M, Máximo V
Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma. European thyroid journal 9: 296-303, 2021. [Article] 
 doi: 10.1159/000509183 PMID: 33718253.
 
9
4.2 (*)
2. Canberk S, Lima AR, Pinto M, Máximo V
Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens. Frontiers in medicine 8: 640460, 2021. [Review] 
 doi: 10.3389/fmed.2021.640460 PMID: 33834032.
 
2
5.1 (*)
3. Canberk S, Lima AR, Pinto M, Soares P, Máximo V
Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application. Frontiers in endocrinology 12: 674666, 2021. [Review] 
 doi: 10.3389/fendo.2021.674666 PMID: 34108939.
 
1
5.6 (*)
4. Lima AR, Correia M, Santos L, Tavares C, Rios E, Canberk S, Soares P, Sobrinho-Simões M, Melo M, Máximo V
S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma. Endocrine 73: 85-97, 2021. [Article] 
 doi: 10.1007/s12020-020-02546-4 PMID: 33219495.
 
1
3.6 (*)
5. Lima AR, Santos L, Correia M, Soares P, Sobrinho-Simões M, Melo M, Máximo V
Dynamin-Related Protein 1 at the Crossroads of Cancer. Genes 9: ., 2018. [Review] 
 doi: 10.3390/genes9020115 PMID: 29466320.
 
51
3.2 (*)
6. Donner LR, Maximo V
Oncocytic Melanoma: A Study of a Rare Entity. The American Journal of dermatopathology 40: 854-856, 2018. [Article] 
 doi: 10.1097/DAD.0000000000001183 PMID: 29771689.
 
0
1.2 (*)
7. Almeida LMCA, Silva R, Cavadas B, Lima J, Pereira L, Soares P, Sobrinho-Simões M, Lopes JM, Máximo V
GLUT1, MCT1/4 and CD147 overexpression supports the metabolic reprogramming in papillary renal cell carcinoma. Histology and histopathology 32: 1029-1040, 2017. [Article] 
 doi: 10.14670/HH-11-863 PMID: 28028797.
 
15
2.0
8. Correia M, Pinheiro P, Batista R, Soares P, Sobrinho-Simões M, Máximo V
Etiopathogenesis of oncocytomas. Seminars in cancer biology 47: 82-94, 2017. [Review] 
 doi: 10.1016/j.semcancer.2017.06.014 PMID: 28687249.
 
7
10.2
9. Boaventura P, Pereira D, Mendes A, Batista R, da Silva AF, Guimarães I, Honavar M, Teixeira-Gomes J, Lopes JM, Máximo V, Soares P
Mitochondrial D310 D-Loop instability and histological subtypes in radiation-induced cutaneous basal cell carcinomas. Journal of dermatological science 73: 31-9, 2014. [Article] 
 doi: 10.1016/j.jdermsci.2013.09.002 PMID: 24091058.
 
14
3.4
10. Moreira S, Correia M, Soares P, Máximo V
GRIM-19 function in cancer development. Mitochondrion 11: 693-9, 2011. [Review] 
 doi: 10.1016/j.mito.2011.05.011 PMID: 21664299.
 
27
3.6
11. Gonçalves AP, Videira A, Soares P, Máximo V
Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR. Life sciences 89: 371-7, 2011. [Article] 
 doi: 10.1016/j.lfs.2011.07.004 PMID: 21807000.
 
22
2.5
12. Sobrinho-Simões M, Máximo V
Warthin's tumour. Virchows Archiv : an international journal of pathology 448: 877-8, 2006. [Letter] 
 doi: 10.1007/s00428-005-0052-x PMID: 16609912.
 
8
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@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
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