NEWTherapies [INEB]

NEWTherapies Group

Coordinator: Mário Barbosa

Deputy Coordinator: Pedro Granja



The main aim of the NEWTherapies Group is to develop Biomaterials and Nanomedicine integrated approaches towards tissue repair and regeneration, focusing mostly on osteoarticular, spine and neurosciences applications. Cell-based therapies for repairing cardiac injuries and novel strategies for prevention, early diagnosis and treatment of cancer are also being explored.


To fulfil these objectives the group is committed to elicit the required biological responses through:

a)    Understanding and guiding matrix-cell and cell-cell interactions;

b)    Designing surfaces and matrices at the molecular level;

c)    Promoting stem cell expansion and targeted differentiation.



The group integrates six complementary teams:

    Biomimetic Microenvironments (Leader: MA Barbosa)

      From understanding to modulating inflammation and stem cell behaviour during intervertebral disc and osteoarticular regeneration and cancer invasion.

    Bone Tissue Engineering (Leader: PL Granja)

      To direct and mechanistically follow cell behavior in engineered 3D microenvironments towards the development of cell-instructive injectable biomaterials for osteoregeneration.

    Biomaterials for Neurosciences (Leader: AP Pêgo)

      By using nanomedicine strategies our team aims at providing in situ and in a targeted manner the required signals to promote nervous tissue regeneration.

    Bioengineered Surfaces (Leader: MCL Martins)

      Surface biofunctionalization towards the design and development of new biomaterials to control specific biological responses.

    Neuro-osteogenesis (Leader: M Lamghari)

      Understand the role of the brain and sympathetic nervous system on bone remodelling and repair.

    Stem Cell Biology (Leader: P Pinto do Ó)

      The focus is at elucidating how stem/progenitor cells engage in regeneration and repair in adult-tissues.



Recent publications

  • Barbosa JN, Amaral IF, Águas AP, Barbosa MA. Evaluation of the effect of the degree of acetylation on the inflammatory response to 3D porous chitosan scaffolds. Journal of Biomedical Materials Research - Part A 2010;93(1):20-8.
  • Bidarra SJ, Barrias CC, Barbosa MA, Soares R, Granja PL. Immobilization of Human Mesenchymal Stem Cells within RGD-Grafted Alginate Microspheres and Assessment of Their Angiogenic Potential. Biomacromolecules 2010; 11 (8): 1956-1964.
  • Cachaco AS, Carvalho T, Santos AC, Igreja C, Fragoso R, Osorio, Ferreira M, Serpa J, Correia S, Pinto-do-O P, Dias S . TNF-alpha Regulates the Effects of Irradiation in the Mouse Bone Marrow Microenvironment. PLOS ONE 2010. 5 (2): Article Number: e8980.
  • da Cunha, CB; Oliveira, C; Wen, XG; Gomes, B; Sousa, S; Suriano, G; Grellier, M; Huntsman, DG; Carneiro, F; Granja, PL; Seruca, R. De novo expression of CD44 variants in sporadic and hereditary gastric cancer. LABORATORY INVESTIGATION 2010; 90 (11): 1604-1614
  • Franquinho, F; Liz, MA; Nunes, AF; Neto, E; Lamghari, M; Sousa, MM. Neuropeptide Y and osteoblast differentiation - the balance between the neuro-osteogenic network and local control. FEBS JOURNAL 2010; 277 (18): 3664-3674
  • Freitas SC, Barbosa MA, Martins MCL. The effect of immobilization of thrombin inhibitors onto self-assembled monolayers on the adsorption and activity of thrombin. Biomaterials 2010;31(14):3772-80
  • Maciel J, Martins MCL, Barbosa MA. The stability of self-assembled monolayers with time and under biological conditions. Journal of Biomedical Materials Research Part A 2010; 94A (3): 833-843.
  • Nunes AF, Liz MA, Franquinho F, Teixeira L, Sousa V, Chenu C, Lamghari M, Sousa MM, Neuropeptide Y expression and function during osteoblast differentiation - insights from transthyretin knockout mice. FEBS JOURNAL 2010. 277 (1) 263-275
  • Oliveira H, Fernandez R, Pires LR, Martins MCL, Simões S, Barbosa MA, Pêgo AP. Targeted gene delivery into peripheral sensorial neurons mediated by self-assembled vectors composed of poly(ethylene imine) and tetanus toxin fragment c. J Controlled Release 2010;143(3):350-8.
  • Santos, JL; Oliveira, H; Pandita, D; Rodrigues, J; Pego, AP; Granja, PL; Tomas, H. Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells. JOURNAL OF CONTROLLED RELEASE 2010. 144 (1): 55-64.
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