Cancer Drug Resistance

Resistance of cancer cells to traditional chemotherapy and targeted therapeutics is both a major clinical problem and a scientific challenge. Different approaches are currently being pursued with a view to overcoming this problem. Our group is mainly focused on translating basic science findings into validation of potentially new molecular targets for cancer therapy, such as anti-apoptotic molecules and some microRNAs, using several in vitro models for different cancer types. Also, in an attempt to counteract cancer drug resistance, we are involved in testing newly synthesized compounds ("small molecules") in particular sets of cancer cell lines.

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