1. Velho S, Oliveira C, Seruca R

KRAS mutations and anti-epidermal growth factor receptor therapy in colorectal cancer with lymph node metastases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27: 158-9; author reply 159, 2009.  [Letter] 

 doi: 10.1200/JCO.2008.20.1525 PMID: 19047277.

 

2. Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM

Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer discovery 3: 294-307, 2013.  [Article] 

 doi: 10.1158/2159-8290.CD-12-0198 PMID: 23274911.

 

3. Matos P, Oliveira C, Velho S, Gonçalves V, da Costa LT, Moyer MP, Seruca R, Jordan P

B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. Gastroenterology 135: 899-906, 2008.  [Article] 

 doi: 10.1053/j.gastro.2008.05.052 PMID: 18602919.

 

4. Dias Carvalho P, Guimarães CF, Cardoso AP, Mendonça S, Costa ÂM, Oliveira MJ, Velho S

KRAS Oncogenic Signaling Extends beyond Cancer Cells to Orchestrate the Microenvironment. Cancer research 78: 7-14, 2018.  [Review] 

 doi: 10.1158/0008-5472.CAN-17-2084 PMID: 29263151.

 

5. Velho S, Oliveira C, Paredes J, Sousa S, Leite M, Matos P, Milanezi F, Ribeiro AS, Mendes N, Licastro D, Karhu A, Oliveira MJ, Ligtenberg M, Hamelin R, Carneiro F, Lindblom A, Peltomaki P, Castedo S, Schwartz S, Jordan P, Aaltonen LA, Hofstra RM, Suriano G, Stupka E, Fialho AM, Seruca R

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours. Human molecular genetics 19: 697-706, 2010.  [Article] 

 doi: 10.1093/hmg/ddp536 PMID: 19955118.

 

6. Oliveira C, Westra JL, Arango D, Ollikainen M, Domingo E, Ferreira A, Velho S, Niessen R, Lagerstedt K, Alhopuro P, Laiho P, Veiga I, Teixeira MR, Ligtenberg M, Kleibeuker JH, Sijmons RH, Plukker JT, Imai K, Lage P, Hamelin R, Albuquerque C, Schwartz S, Lindblom A, Peltomaki P, Yamamoto H, Aaltonen LA, Seruca R, Hofstra RM

Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. Human molecular genetics 13: 2303-11, 2004.  [Article] 

 doi: 10.1093/hmg/ddh238 PMID: 15294875.

 

7. Oliveira C, Velho S, Domingo E, Preto A, Hofstra RM, Hamelin R, Yamamoto H, Seruca R, Schwartz S

Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. Oncogene 24: 7630-4, 2005.  [Article] 

 doi: 10.1038/sj.onc.1208906 PMID: 16007118.

 

8. Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha AF, Duval A, Hamelin R, Machado JC, Schwartz S, Carneiro F, Seruca R

KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. Oncogene 26: 158-63, 2007.  [Article] 

 doi: 10.1038/sj.onc.1209758 PMID: 16953233.

 

9. Davalos V, Dopeso H, Velho S, Ferreira AM, Cirnes L, Díaz-Chico N, Bilbao C, Ramírez R, Rodríguez G, Falcón O, León L, Niessen RC, Keller G, Dallenbach-Hellweg G, Espín E, Armengol M, Plaja A, Perucho M, Imai K, Yamamoto H, Gebert JF, Díaz-Chico JC, Hofstra RM, Woerner SM, Seruca R, Schwartz S, Arango D

High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability. Oncogene 26: 308-11, 2007.  [Article] 

 doi: 10.1038/sj.onc.1209780 PMID: 16819508.

 

10. Dias Carvalho P, Machado AL, Martins F, Seruca R, Velho S

Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors. Cancers 11: ., 2019.  [Review] 

 doi: 10.3390/cancers11122010 PMID: 31847096.

 

11. Velho S, Corso G, Oliveíra C, Seruca R

KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers. Advances in cancer research 109: 123-43, 2010.  [Review; Book Chapter] 

 doi: 10.1016/B978-0-12-380890-5.00004-1 PMID: 21070916.

 

12. Corso G, Velho S, Paredes J, Pedrazzani C, Martins D, Milanezi F, Pascale V, Vindigni C, Pinheiro H, Leite M, Marrelli D, Sousa S, Carneiro F, Oliveira C, Roviello F, Seruca R

Oncogenic mutations in gastric cancer with microsatellite instability. European journal of cancer (Oxford, England : 1990) 47: 443-51, 2011.  [Article] 

 doi: 10.1016/j.ejca.2010.09.008 PMID: 20937558.

 

13. Alazzouzi H, Suriano G, Guerra A, Plaja A, Espín E, Armengol M, Alhopuro P, Velho S, Shinomura Y, González-Aguilera JJ, Yamamoto H, Aaltonen LA, Moreno V, Capellà G, Peinado MA, Seruca R, Arango D, Schwartz S

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells. Journal of medical genetics 44: 75-80, 2007.  [Article] 

 doi: 10.1136/jmg.2006.042572 PMID: 16825434.

 

14. Fernandes MS, Melo S, Velho S, Carneiro P, Carneiro F, Seruca R

Specific inhibition of p110a subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers. Oncotarget 7: 68546-68558, 2016.  [Article] 

 doi: 10.18632/oncotarget.11843 PMID: 27602501.

 

15. Preto A, Figueiredo J, Velho S, Ribeiro AS, Soares P, Oliveira C, Seruca R

BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. The Journal of pathology 214: 320-7, 2008.  [Article] 

 doi: 10.1002/path.2295 PMID: 18098337.

 

16. Carneiro P, Moreira AM, Figueiredo J, Barros R, Oliveira P, Fernandes MS, Ferro A, Almeida R, Oliveira C, Carneiro F, Schmitt F, Paredes J, Velho S, Seruca R

S100P is a molecular determinant of E-cadherin function in gastric cancer. Cell communication and signaling : CCS 17: 155, 2019.  [Article] 

 doi: 10.1186/s12964-019-0465-9 PMID: 31767037.

 

17. Velho S, Oliveira C, Ferreira A, Ferreira AC, Suriano G, Schwartz S, Duval A, Carneiro F, Machado JC, Hamelin R, Seruca R

The prevalence of PIK3CA mutations in gastric and colon cancer. European journal of cancer (Oxford, England : 1990) 41: 1649-54, 2005.  [Article] 

 doi: 10.1016/j.ejca.2005.04.022 PMID: 15994075.

 

18. Velho S, Haigis KM

Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras Experimental cell research  1, 2011.  [Review] 

 PMID: 21741971.

 

19. Velho S, Pinto A, Licastro D, Oliveira MJ, Sousa F, Stupka E, Seruca R

Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation. BMC cancer 14: 182, 2014.  [Article] 

 doi: 10.1186/1471-2407-14-182 PMID: 24628919.

 

20. Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis? BMC cancer 8: 255, 2008.  [Article] 

 doi: 10.1186/1471-2407-8-255 PMID: 18782444.

 

21. Pinto AT, Pinto ML, Velho S, Pinto MT, Cardoso AP, Figueira R, Monteiro A, Marques M, Seruca R, Barbosa MA, Mareel M, Oliveira MJ, Rocha S

Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation. PloS one 11: e0160891, 2016.  [Article] 

 PMID: 27513864.

 

22. Meireles AM, Preto A, Rocha AS, Rebocho AP, Máximo V, Pereira-Castro I, Moreira S, Feijão T, Botelho T, Marques R, Trovisco V, Cirnes L, Alves C, Velho S, Soares P, Sobrinho-Simões M

Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines. Thyroid : official journal of the American Thyroid Association 17: 707-15, 2007.  [Article] 

 doi: 10.1089/thy.2007.0097 PMID: 17725429.

 

23. Velho S, Fernandes MS, Leite M, Figueiredo C, Seruca R

Causes and consequences of microsatellite instability in gastric carcinogenesis. World journal of gastroenterology 20: 16433-42, 2014.  [Article] 

 doi: 10.3748/wjg.v20.i44.16433 PMID: 25469011.

 

24. Pedrazzani C, Corso G, Velho S, Leite M, Pascale V, Bettarini F, Marrelli D, Seruca R, Roviello F

Evidence of tumor microsatellite instability in gastric cancer with familial aggregation. Familial cancer 8: 215-20, 2009.  [Article] 

 doi: 10.1007/s10689-008-9231-7 PMID: 19152022.

 

25. Preto A, Moutinho C, Velho S, Oliveira C, Rebocho AP, Figueiredo J, Soares P, Lopes JM, Seruca R

A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation. Virchows Archiv : an international journal of pathology 450: 619-26, 2007.  [Article] 

 doi: 10.1007/s00428-007-0420-9 PMID: 17487504.

 

26. Seruca R, Velho S, Oliveira C, Leite M, Matos P, Jordan P

Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors. Expert review of gastroenterology & hepatology 3: 5-9, 2009.  [] 

 doi: 10.1586/17474124.3.1.5 PMID: 19210107.