Luciana Ferreira
Name: Luciana Ferreira
E-mail: lferreira@ipatimup.pt
Extension: 
225570700
Academic Degree: Master's Degree


Luciana Ferreira
Luciana Ferreira
Member of
Affiliated Researcher of Cancer Signalling & Metabolism


Short CV
Name: Luciana Bueno Ferreira
Date of Birth: April 8th, 1981
Nationality: Brazilian
Institucional address: Ipatimup- Rua Roberto Frias s/n 4200-Porto-Portugal Email : lferreira@ipatimup.pt

Academic degrees:
2011 M.S. in Molecular Oncology, National Cancer Institute, Brazil
2007 B.S. in Biology, Federal University of Uberlândia, Brazil

Research Experience

2011-2012 Research Assistant, National Cancer Institute, Brazil.
2011 Organizer of a Summer School, National Cancer Institute, Brazil
2009-2011 Master Student, National Cancer Institute, Brazil. Advisor: Etel Gimba
2010 Teacher of a Summer School, National Cancer Institute, Brazil
2007-2008 Research Assistant, National Cancer Institute, Brazil. Advisor Etel Gimba
2006-2007 Trainee, Federal University of Uberlândia, Brazil. Advisor: Luiz Goulart 2006 Course Monitor, Federal University of Uberlândia, Brazil. Advisor: Luiz Goulart
2005-2006 Trainee, Federal University of Uberlândia, Brazil. Advisor: Luiz Goulart


Fellowships
2012 Fellowship holder of ""CNPq"" – Science without Borders
2011-2012 Fellowship holder of Brazilian Ministry of Health
2008-2010 Fellowship holder of CAPES
2007-2008 Fellowship holder of Brazilian Ministry of Health
2006-2007 Fellowship holder of FAPEMIG

Original Articles
Palumbo A, Ferreira LB et al. Extracellular matrix secreted by reactive stroma is a main inducer of pro-tumorigenic features on LNCaP prostate cancer cells. Cancer Letters. 2012
Tilli TM, Mello KD, Ferreira LB et al. Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells. The Prostate. 2012
Ferreira LB et al. The non-coding RNA PCA3 may control prostate cancer cell survival by modulating androgen receptor signaling. BMC Cancer. 2012, 12: 507 (Highly accessed)

Highlights
Papillary thyroid carcinoma - PTC is the most frequent malignant tumor of thyroid. Among the gene products aberrantly expressed in PTC, include isoforms of the osteopontin (OPNa, OPNb and OPNc). OPN acts as a matrix component interacting with cell surface receptors and integrins, activating signaling pathways increasing survival, migration, etc. Our group characterized the functional roles of OPN isoforms in different tumors. In prostate cancer, it was shown that OPNb and OPNc overexpression in cells is able to activate proliferation. In ovarian tumor, OPNc has pro-tumorigenic activity. The aim of this work is to investigate the OPN functional role in PTC, and to evaluate the cellular and molecular effects of OPN isoforms overexpression in thyroid cancer cell lines. This project can contribute to determine alterations involved in malignant transformation, providing knowledge on the mechanisms of OPN action on the regulation and control of the expression of key genes to the onset of PTC

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