Raquel Almeida
Name: Raquel Almeida
E-mail: ralmeida@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


Raquel Almeida
Raquel Almeida
Member of


Short CV
Personal data

Name: Raquel Maria da Silva Graça Almeida
Birth date: 4th January 1973
Nationality: Portuguese
Email: ralmeida@ipatimup.pt

Academic degrees

Oct 2000 – PhD in Biomedicine, Faculty of Medicine of the University of Porto.
Oct 1996 – Master Degree in Oncobiology, Faculty of Medicine of the University of Porto.
Jun 1994 – Graduation in Biology, Faculty of Sciences of the University of Porto (classification 15/20).

Previous and current scientific and/or professional activities

Since 2005 – Affiliated professor at the Faculty of Medicine of the University of Porto
Since Jul 2004 – Researcher at Ipatimup
Nov 2000 – Jun 2004 – Post-doctoral fellow at Ipatimup
Nov 1996 – Oct 2000 – PhD student at the Faculty of Health Sciences, Copenhagen, Denmark and Ipatimup
Nov 1994 – Oct 1996 – Master student at Ipatimup and the Faculty of Health Sciences, Copenhagen, Denmark

Supervising experience

Post-docs

Since Jan 2011 - Supervisor of Rita Henriques Pinto de Barros (Co-supervisor – Prof. Gijs van den Brink, University of Amsterdam, Amsterdam, The Netherlands): “Mouse models of intestinal

Ongoing PhD thesis

Since April 2011 – Supervisor of Ana Adelaide Direito Sadio (Co-supervisor – Ana Paula Pêgo, INEB): “Reverting Gastric Intestinal Metaplasia using siRNAs directed to CDX2”. Programa Doutoral em Educação Médica Avançada Gulbenkian/Champalimaud

Since April 2011 - Co-supervisor of Rita Isabel Morais Pinto (Supervisor - Leonor David, Ipatimup and Medical Faculty of Porto, Porto, Portugal): ""Cancer-associated sialyl-Tn carbohydrate antigen - regulation of its expression by CDX2 homeoprotein and contribution of mucin protein carriers for cancer progression""

Since Jan 2010 - Supervisor of Vânia Raquel Gomes Camilo (Co-supervisor - Markus Gerhard, Technical University of Munich, Germany): ""Sox2 modulation in the establishment of CDX2-dependent intestinal metaplasia of the stomach""

Since Jan 2009 - Supervisor of Bruno Miguel

Highlights
I have been involved in the understanding of the molecular basis of the gastric preneoplastic lesion intestinal metaplasia and intestinal differentiation of gastric carcinomas. We were among the first groups to identify the functional relevance of the transcription factor CDX2 in intestinal metaplasia and we are currently involved in understanding how this protein becomes de novo expressed in the stomach. Transcriptional and post-transcriptional regulatory mechanisms have been identified. Understanding this process is not only likely to increase our knowledge on the normal mechanisms of differentiation but also, since metaplasia is a precursor lesion to gastric cancer, it will increase our possibilities of developing early diagnostic and therapeutic strategies.

Supervisor of
Alexandre Dias, Master Student (thesis)
Ana Sadio, PhD Student
Filipa Ponte, Post Doc
Bruno Pereira, Post Doc
Diana Pádua, Master Student (thesis)
Helena Gouveia, PhD Student
Joana Oliveira, Affiliated Researcher
Lara Marcos da Silva, Affiliated Researcher
Nair Lopes, Visiting Researcher
Patrícia Mesquita, Investigador Auxiliar
Rita Barros, Post Doc
Sara Ricardo, Investigador Auxiliar

PI (running)

PI (closed)
First Author
 
C
IF
1. Almeida R, Almeida J, Shoshkes M, Mendes N, Mesquita P, Silva E, Van Seuningen I, Reis CA, Santos-Silva F, David L
 doi: 10.1002/path.1861 PMID: 16278805.
 
2. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolós C, David L
 doi: 10.1002/path.1246 PMID: 12474224.
 
3. Almeida R, Levery SB, Mandel U, Kresse H, Schwientek T, Bennett EP, Clausen H
 PMID: 10473568.
 
Senior Author
 
C
IF
1. Camilo V, Garrido M, Valente P, Ricardo S, Amaral AL, Barros R, Chaves P, Carneiro F, David L, Almeida R
 doi: 10.1111/his.12544 PMID: 25196071.
 
2. Camilo V, Barros R, Celestino R, Castro P, Vieira J, Teixeira MR, Carneiro F, Pinto-de-Sousa J, David L, Almeida R
 
3. Sadio A, Gustafsson JK, Pereira B, Gomes CP, Hansson GC, David L, Pêgo AP, Almeida R
 
4. Pereira B, Sousa S, Barros R, Carreto L, Oliveira P, Oliveira C, Chartier NT, Plateroti M, Rouault JP, Freund JN, Billaud M, Almeida R
 doi: 10.1093/nar/gkt087 PMID: 23408853.
 
5. Pereira B, Le Borgne M, Chartier NT, Billaud M, Almeida R
MEX-3 proteins: recent insights on novel post-transcriptional regulators. Trends in biochemical sciences 38: 477-9, 2013. [Editorial Material] 
 
6. Barros R, Freund JN, David L, Almeida R
Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends in molecular medicine 18: 555-63, 2012. [Review] 
 
7. Camilo V, Barros R, Sousa S, Magalhães AM, Lopes T, Mário Santos A, Pereira T, Figueiredo C, David L, Almeida R
 
8. Barros R, da Costa LT, Pinto-de-Sousa J, Duluc I, Freund JN, David L, Almeida R
 
9. Barros R, Camilo V, Pereira B, Freund JN, David L, Almeida R
Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation. Biochemical Society transactions 38: 358-63, 2010. [Article; Proceedings Paper] 
 doi: 10.1042/BST0380358 PMID: 20298183.
 
CDX2 expression is induced by Helicobacter pylori in AGS cells. Scandinavian journal of gastroenterology 44: 124-5, 2009. [Letter] 
 
CDX2 promoter methylation is not associated with mRNA expression. International journal of cancer 125: 1739-42, 2009. [Letter] 
 doi: 10.1002/ijc.24544 PMID: 19569237.
 
12. Barros R, Mendes N, Howe JR, Reis CA, de Bolos C, Carneiro F, David L, Almeida R
 
13. Pereira B, Oliveira C, David L, Almeida R
CDX2 Promoter Methylation is not Associated with mRNA Expression Helicobacter 14: 385-385, 2009. [Meeting Abstract] 
.
 
14. Camilo V, Barros R, Pereira B, Magalhaes A, Reis C, Freund J, David L, David L, Almeida R
BMP and H-pylori Downregulate SOX2 Expression in Gastric Cell Lines Helicobacter 14: 330-330, 2009. [Meeting Abstract] 
.
 
15. Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R
 doi: 10.1002/path.2369 PMID: 18498120.
 
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