Salomé Pinho
Name: Salomé Pinho
Academic Degree: PhD

Salomé Pinho
Salomé Pinho
Member of

Short CV
Salomé Pinho received her D.V.M. from the University of Porto in 2004 and developed her PhD research at the Institute of Molecular Pathology and Immunology of Univ. Porto (IPATIMUP) and at Boston Medical School, MA, USA from 2006 to 2009. She performed her postdoctoral work at IPATIMUP in the glycobiology and disease field. At present, she is Researcher (PI) at IPATIMUP/i3S and affiliated Professor at Faculty of Medicine at University of Porto. Her research activity is focused on the understanding of the role of post-translational modifications by glycosylation in the regulation of key proteins´ functions involved in cancer and in chronic inflammatory conditions, envisioning potential clinical applications. She is author of several publications in international peer-reviewed journals (as first and senior author) including Nature Reviews Cancer, Oncogene and Human Molecular Genetics. She supervises a research team composed by Post-Docs, PhD students, Master students and young researchers. She is the Principal Investigator of several national/international funded projects in the field of cancer and inflammatory diseases. She received the Young Investigator Award from the European Association for Cancer Research and is inventor of 2 patents.

- To uncover the role of post-translational modifications by glycosylation in the regulation of pivotal proteins involved in the process of cancer cell invasion and metastases envisioning potential clinical applications.

- To identify novel molecular mechanisms and potential biomarkers, based in glycosylation modifications, that may underlie the pathogenesis of pre-cancerous diseases such as Inflammatory Bowel Disease. Potential therapeutic applications.

Supervisor of
Catarina Azevedo, PhD Student
PhD student
Rita Amorim, PhD Student
PhD student
Ângela Fernandes, Junior Researcher
Junior Researcher
Ariana Correia-Silva, Research Fellowship (MSc)
Beatriz Pereira, PhD Student
PhD student
Carolina Dantas, Fellow
Research Fellowship (MSc)
Cláudia Rodrigues, PhD Student
Eduarda Gomes, PhD Student
PhD student
Guilherme Faria, Fellow
PhD student
Inês Alves, Junior Researcher
Junior Researcher
Joana Gaifem, Junior Researcher
Junior Researcher
João Carvalho, Master Student (theoretical phase)
MSc student
João Pereira, PhD Fellowship
Leticia Gomes, Junior Researcher
Junior Researcher
Manuel Mourato, Master Student (thesis)
MSc student
Manuel Vicente, Collaborator
External Consultant
Mariana Moreira, Master Student (theoretical phase)
MSc student
Pedro Almeida, Research Technician
Research Technician
Pedro Cabral, PhD Student
PhD student
Rafaela Nogueira, Fellow
Research Fellowship (MSc)
Vanda Pinto, Research Technician
Research Technician

PI (running)

PI (closed)
First Author
Glycosylation in cancer: mechanisms and clinical implications. Nature reviews. Cancer 15: 540-55, 2015. [Review] 
 doi: 10.1038/nrc3982 PMID: 26289314.
2. Pinho SS, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhães A, Gärtner F, Mendonfa AM, Isaji T, Gu J, Carneiro F, Seruca R, Taniguchi N, Reis CA
 PMID: 23671930.
3. Pinho SS, Carvalho S, Marcos-Pinto R, Magalhães A, Oliveira C, Gu J, Dinis-Ribeiro M, Carneiro F, Seruca R, Reis CA
Gastric cancer: adding glycosylation to the equation. Trends in molecular medicine 19: 664-76, 2013. [Review] 
4. Pinho SS, Carvalho S, Cabral J, Reis CA, Gärtner F
Canine tumors: a spontaneous animal model of human carcinogenesis. Translational research : the journal of laboratory and clinical medicine 159: 165-72, 2012. [Review] 
5. Pinho SS, Oliveira P, Cabral J, Carvalho S, Huntsman D, Gärtner F, Seruca R, Reis CA, Oliveira C
6. Pinho SS, Seruca R, Gärtner F, Yamaguchi Y, Gu J, Taniguchi N, Reis CA
Modulation of E-cadherin function and dysfunction by N-glycosylation. Cellular and molecular life sciences : CMLS 68: 1011-20, 2011. [Review] 
 doi: 10.1093/hmg/ddp194 PMID: 19403558.
8. Pinho SS, Osório H, Nita-Lazar M, Gomes J, Lopes C, Gärtner F, Reis CA
Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochemical and biophysical research communications 379: 1091-6, 2009. [Article] 
9. Pinho SS, Reis CA, Gärtner F, Alpaugh ML
10. Pinho SS, Matos AJ, Lopes C, Marcos NT, Carvalheira J, Reis CA, Gärtner F
Senior Author
1. Alves I, Fernandes Â, Santos-Pereira B, Azevedo CM, Pinho SS
2. Vicente MM, Alves I, Gaifem J, Rodrigues CS, Fernandes Â, Dias AM, Štambuk J, Petrovic T, Oliveira P, Ferreira-da-Silva F, Soares A, Seixas N, Teixeira T, Malheiro L, Abreu MM, Lauc G, Sarmento E Castro R, Pinho SS
Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity. European journal of immunology 52: 946-957, 2022. [Article] 
3. Alves I, Vicente MM, Gaifem J, Fernandes Â, Dias AM, Rodrigues CS, Oliveira JC, Seixas N, Malheiro L, Abreu MA, Sarmento E Castro R, Pinho SS
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis. Journal of immunology (Baltimore, Md. : 1950) 207: 1591-1598, 2021. [Article] 
4. Alves I, Santos-Pereira B, Dalebout H, Santos S, Vicente MM, Campar A, Thepaut M, Fieschi F, Strahl S, Boyaval F, Vizcaíno R, Silva R, Holst-Bernal S, Vasconcelos C, Santos L, Wuhrer M, Marinho A, Heijs B, Pinho SS
 doi: 10.1002/art.41768 PMID: 33881228.
5. Alves I, Vicente MM, Dias AM, Gaifem J, Rodrigues C, Campar A, Pinho SS
The Role of Glycosylation in Inflammatory Diseases. Advances in experimental medicine and biology 1325: 265-283, 2021. [Article; Book Chapter] 
6. Verhelst X, Dias AM, Colombel JF, Vermeire S, Van Vlierberghe H, Callewaert N, Pinho SS
7. Pereira MS, Durães C, Catarino TA, Costa JL, Cleynen I, Novokmet M, Krištic J, Štambuk J, Conceição-Neto N, Machado JC, Marcos-Pinto R, Magro F, Vermeire S, Lauc G, Lago P, Pinho SS
8. Pereira MS, Maia L, Azevedo LF, Campos S, Carvalho S, Dias AM, Albergaria A, Lima J, Marcos-Pinto R, Lago P, Pinho SS
A [Glyco]biomarker that Predicts Failure to Standard Therapy in Ulcerative Colitis Patients. Journal of Crohn's & colitis 13: 39-49, 2019. [Article] 
9. Dias AM, Correia A, Pereira MS, Almeida CR, Alves I, Pinto V, Catarino TA, Mendes N, Leander M, Oliva-Teles MT, Maia L, Delerue-Matos C, Taniguchi N, Lima M, Pedroto I, Marcos-Pinto R, Lago P, Reis CA, Vilanova M, Pinho SS
Metabolic control of T cell immune response through glycans in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America 115: E4651-E4660, 2018. [Article] 
10. Pereira MS, Alves I, Vicente M, Campar A, Silva MC, Padrão NA, Pinto V, Fernandes Â, Dias AM, Pinho SS
Glycans as Key Checkpoints of T Cell Activity and Function. Frontiers in immunology 9: 2754, 2018. [Review] 
11. de-Freitas-Junior JCM, Andrade-da-Costa J, Silva MC, Pinho SS
Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression. International journal of molecular sciences 18: ., 2017. [Review] 
12. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gärtner F, Sanches JM, Ruppert T, Miyoshi E, Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Reis CA, Pinho SS
13. Carvalho S, Oliveira T, Bartels MF, Miyoshi E, Pierce M, Taniguchi N, Carneiro F, Seruca R, Reis CA, Strahl S, Pinho SS
14. Dias AM, Almeida CR, Reis CA, Pinho SS
Studying T Cells N-Glycosylation by Imaging Flow Cytometry. Methods in molecular biology (Clifton, N.J.) 1389: 167-76, 2016. [] 
15. Bassagañas S, Carvalho S, Dias AM, Pérez-Garay M, Ortiz MR, Figueras J, Reis CA, Pinho SS, Peracaula R
16. Dias AM, Dourado J, Lago P, Cabral J, Marcos-Pinto R, Salgueiro P, Almeida CR, Carvalho S, Fonseca S, Lima M, Vilanova M, Dinis-Ribeiro M, Reis CA, Pinho SS
 doi: 10.1093/hmg/ddt632 PMID: 24334766.
17. de-Freitas-Junior JC, Carvalho S, Dias AM, Oliveira P, Cabral J, Seruca R, Oliveira C, Morgado-Díaz JA, Reis CA, Pinho SS
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