RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH
 
Salomé Pinho
Name: Salomé Pinho
E-mail: salomep@i3s.up.pt
Extension: 
225570700
Academic Degree: PhD


Salomé Pinho
Salomé Pinho
Member of
Temporary of Immunology, Cancer and Glycomedicine


Short CV
Salomé Pinho received her D.V.M. from the University of Porto in 2004 and developed her PhD research at the Institute of Molecular Pathology and Immunology of Univ. Porto (IPATIMUP) and at Boston Medical School, MA, USA from 2006 to 2009. She performed her postdoctoral work at IPATIMUP in the glycobiology and disease field. At present, she is Researcher (PI) at IPATIMUP/i3S and affiliated Professor at Faculty of Medicine at University of Porto. Her research activity is focused on the understanding of the role of post-translational modifications by glycosylation in the regulation of key proteins´ functions involved in cancer and in chronic inflammatory conditions, envisioning potential clinical applications. She is author of several publications in international peer-reviewed journals (as first and senior author) including Nature Reviews Cancer, Oncogene and Human Molecular Genetics. She supervises a research team composed by Post-Docs, PhD students, Master students and young researchers. She is the Principal Investigator of several national/international funded projects in the field of cancer and inflammatory diseases. She received the Young Investigator Award from the European Association for Cancer Research and is inventor of 2 patents.

Highlights
- To uncover the role of post-translational modifications by glycosylation in the regulation of pivotal proteins involved in the process of cancer cell invasion and metastases envisioning potential clinical applications.

- To identify novel molecular mechanisms and potential biomarkers, based in glycosylation modifications, that may underlie the pathogenesis of pre-cancerous diseases such as Inflammatory Bowel Disease. Potential therapeutic applications.

Supervisor of
Catarina Azevedo, PhD Student
PhD student
Rita Amorim, PhD Student
PhD student
Ângela Fernandes, Research Technician
Research Technician
Beatriz Pereira, PhD Student
PhD student
Carolina Dantas, Research Fellowship (MSc)
Temporary
Cláudia Rodrigues, PhD Student
Cláudia Bessa, Junior Researcher
Temporary
Eduarda Gomes, PhD Student
PhD student
Guilherme Faria, Research technician fellowship
Temporary
Inês Alves, Junior Researcher
Temporary
Joana Gaifem, Junior Researcher
Junior Researcher
Pedro Almeida, Master Student (thesis)
MSc student
Rafaela Nogueira, Master Student (thesis)
MSc student
Vanda Pinto, Research Technician
Temporary

PI (running)
Glycans as immunomodulators in Inflammatory Bowel Disease
Glycans in colitis-associated colorectal cancer
Glycome as a predictor of IBD development
Glycome as a predictor of Inflammatory Bowel Disease development.

PI (closed)
GLICOSILAÇÃO NA HEPATITE AUTOIMUNE: IDENTIFICAÇÃO DE UM NOVO BIOMARCADOR NÃO-INVASIVO PARA DIAGNÓSTICO E PROGNÓSTICO”
GLYCO-LUPUS: Glicanos na autoimunidade. Impacto na patogénese e tratamento do Lupus Eritematoso Sistémico.
Glycans as novel immunomodulators in Idiopathic Inflammatory Myopathies
Glycans as immunomodulators in IBD
How sick will the coronavirus make you?The answer may be in your plasma IgG glycome signature
Glycans as novel immunomodulators in Inflammatory Bowel Disease: an opportunity for new therapeutic strategies.
Glycasylation of T cells in Inflammatory Bowel Disease
Impact of glycosylation in the pathogenesis of hepatocellular carcinoma
MGAT5 as a potencial new gene determining severity in inflammatory Bowel Disease
Identification of a potential new prognostic biomarker to select IBD patients that fail standard therapy.
Glycosylation of the T cell receptor: a new mechanism underlying IBD pathogenesis Icuplications for therapy stratification
Glicosilação e cancro: da glicómia funcional à aplicação clínica
T cell receptor N-glycosylation as a new mechanism underlying Inflammatory Bowel Disease pathogenesis. Implications for therapy.
E-cadherin Post-Translational Modifications by N-glycosylation: a potencial new mechanism of E-cadherin deregulation in cancer
First Author
 
C
IF
1. Pinho SS, Reis CA
Glycosylation in cancer: mechanisms and clinical implications. Nature reviews. Cancer 15: 540-55, 2015. [Review] 
 doi: 10.1038/nrc3982 PMID: 26289314.
 
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34.2
2. Pinho SS, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhães A, Gärtner F, Mendonfa AM, Isaji T, Gu J, Carneiro F, Seruca R, Taniguchi N, Reis CA
E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V. Biochimica et biophysica acta 1830: 2690-700, 2013. [Article] 
 PMID: 23671930.
 
79
3.8
3. Pinho SS, Carvalho S, Marcos-Pinto R, Magalhães A, Oliveira C, Gu J, Dinis-Ribeiro M, Carneiro F, Seruca R, Reis CA
Gastric cancer: adding glycosylation to the equation. Trends in molecular medicine 19: 664-76, 2013. [Review] 
 doi: 10.1016/j.molmed.2013.07.003 PMID: 23932995.
 
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10.1
4. Pinho SS, Carvalho S, Cabral J, Reis CA, Gärtner F
Canine tumors: a spontaneous animal model of human carcinogenesis. Translational research : the journal of laboratory and clinical medicine 159: 165-72, 2012. [Review] 
 doi: 10.1016/j.trsl.2011.11.005 PMID: 22340765.
 
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5. Pinho SS, Oliveira P, Cabral J, Carvalho S, Huntsman D, Gärtner F, Seruca R, Reis CA, Oliveira C
Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions. PloS one 7: e33191, 2012. [Article] 
 doi: 10.1371/journal.pone.0033191 PMID: 22427986.
 
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6. Pinho SS, Seruca R, Gärtner F, Yamaguchi Y, Gu J, Taniguchi N, Reis CA
Modulation of E-cadherin function and dysfunction by N-glycosylation. Cellular and molecular life sciences : CMLS 68: 1011-20, 2011. [Review] 
 doi: 10.1007/s00018-010-0595-0 PMID: 21104290.
 
107
6.6
7. Pinho SS, Reis CA, Paredes J, Magalhães AM, Ferreira AC, Figueiredo J, Xiaogang W, Carneiro F, Gärtner F, Seruca R
The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. Human molecular genetics 18: 2599-608, 2009. [Article] 
 doi: 10.1093/hmg/ddp194 PMID: 19403558.
 
83
7.4
8. Pinho SS, Osório H, Nita-Lazar M, Gomes J, Lopes C, Gärtner F, Reis CA
Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochemical and biophysical research communications 379: 1091-6, 2009. [Article] 
 doi: 10.1016/j.bbrc.2009.01.024 PMID: 19159617.
 
58
2.6 (*)
9. Pinho SS, Reis CA, Gärtner F, Alpaugh ML
Molecular plasticity of E-cadherin and sialyl lewis x expression, in two comparative models of mammary tumorigenesis. PloS one 4: e6636, 2009. [Article] 
 doi: 10.1371/journal.pone.0006636 PMID: 19675678.
 
13
4.4
10. Pinho SS, Matos AJ, Lopes C, Marcos NT, Carvalheira J, Reis CA, Gärtner F
Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression. BMC cancer 7: 124, 2007. [Article] 
 doi: 10.1186/1471-2407-7-124 PMID: 17617904.
 
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2.7
Senior Author
 
C
IF
1. Alves I, Santos-Pereira B, Dalebout H, Santos S, Vicente MM, Campar A, Thepaut M, Fieschi F, Strahl S, Boyaval F, Vizcaíno R, Silva R, Holst-Bernal S, Vasconcelos C, Santos L, Wuhrer M, Marinho A, Heijs B, Pinho SS
Protein Mannosylation as a Diagnostic and Prognostic Biomarker of Lupus Nephritis: An Unusual Glycan Neoepitope in Systemic Lupus Erythematosus. Arthritis & rheumatology (Hoboken, N.J.) 73: 2069-2077, 2021. [Article] 
 doi: 10.1002/art.41768 PMID: 33881228.
 
0
11.0 (*)
2. Alves I, Vicente MM, Dias AM, Gaifem J, Rodrigues C, Campar A, Pinho SS
The Role of Glycosylation in Inflammatory Diseases. Advances in experimental medicine and biology 1325: 265-283, 2021. [Article; Book Chapter] 
 doi: 10.1007/978-3-030-70115-4_13 PMID: 34495540.
 
0
2.6 (*)
3. Alves I, Vicente MM, Gaifem J, Fernandes Â, Dias AM, Rodrigues CS, Oliveira JC, Seixas N, Malheiro L, Abreu MA, Sarmento E Castro R, Pinho SS
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis. Journal of immunology (Baltimore, Md. : 1950) 207: 1591-1598, 2021. [Article] 
 doi: 10.4049/jimmunol.2100131 PMID: 34417260.
 
0
5.4 (*)
4. Verhelst X, Dias AM, Colombel JF, Vermeire S, Van Vlierberghe H, Callewaert N, Pinho SS
Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases. Gastroenterology 158: 95-110, 2020. [Review] 
 doi: 10.1053/j.gastro.2019.08.060 PMID: 31626754.
 
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17.4 (*)
5. Pereira MS, Durães C, Catarino TA, Costa JL, Cleynen I, Novokmet M, Krištic J, Štambuk J, Conceição-Neto N, Machado JC, Marcos-Pinto R, Magro F, Vermeire S, Lauc G, Lago P, Pinho SS
Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis. Clinical and translational gastroenterology 11: e00166, 2020. [Article] 
 doi: 10.14309/ctg.0000000000000166 PMID: 32352685.
 
5
4.0 (*)
6. Pereira MS, Maia L, Azevedo LF, Campos S, Carvalho S, Dias AM, Albergaria A, Lima J, Marcos-Pinto R, Lago P, Pinho SS
A [Glyco]biomarker that Predicts Failure to Standard Therapy in Ulcerative Colitis Patients. Journal of Crohn's & colitis 13: 39-49, 2019. [Article] 
 doi: 10.1093/ecco-jcc/jjy139 PMID: 30239648.
 
7
8.7
7. Pereira MS, Alves I, Vicente M, Campar A, Silva MC, Padrão NA, Pinto V, Fernandes Â, Dias AM, Pinho SS
Glycans as Key Checkpoints of T Cell Activity and Function. Frontiers in immunology 9: 2754, 2018. [Review] 
 doi: 10.3389/fimmu.2018.02754 PMID: 30538706.
 
38
5.5 (*)
8. Dias AM, Correia A, Pereira MS, Almeida CR, Alves I, Pinto V, Catarino TA, Mendes N, Leander M, Oliva-Teles MT, Maia L, Delerue-Matos C, Taniguchi N, Lima M, Pedroto I, Marcos-Pinto R, Lago P, Reis CA, Vilanova M, Pinho SS
Metabolic control of T cell immune response through glycans in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America 115: E4651-E4660, 2018. [Article] 
 doi: 10.1073/pnas.1720409115 PMID: 29720442.
 
37
9.5 (*)
9. de-Freitas-Junior JCM, Andrade-da-Costa J, Silva MC, Pinho SS
Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression. International journal of molecular sciences 18: ., 2017. [Review] 
 doi: 10.3390/ijms18091921 PMID: 28880250.
 
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10. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gärtner F, Sanches JM, Ruppert T, Miyoshi E, Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Reis CA, Pinho SS
Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer. Oncogene 35: 1619-31, 2016. [Article] 
 doi: 10.1038/onc.2015.225 PMID: 26189796.
 
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7.5
11. Carvalho S, Oliveira T, Bartels MF, Miyoshi E, Pierce M, Taniguchi N, Carneiro F, Seruca R, Reis CA, Strahl S, Pinho SS
O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer. Oncotarget 7: 65231-65246, 2016. [Article] 
 doi: 10.18632/oncotarget.11245 PMID: 27533452.
 
22
5.2
12. Dias AM, Almeida CR, Reis CA, Pinho SS
Studying T Cells N-Glycosylation by Imaging Flow Cytometry. Methods in molecular biology (Clifton, N.J.) 1389: 167-76, 2016. [] 
 doi: 10.1007/978-1-4939-3302-0_11 PMID: 27460244.
 
0
-
13. Bassagañas S, Carvalho S, Dias AM, Pérez-Garay M, Ortiz MR, Figueras J, Reis CA, Pinho SS, Peracaula R
Pancreatic Cancer Cell Glycosylation Regulates Cell Adhesion and Invasion through the Modulation of a2ß1 Integrin and E-Cadherin Function. PloS one 9: e98595, 2014. [Article] 
 doi: 10.1371/journal.pone.0098595 PMID: 24878505.
 
44
3.2
14. Dias AM, Dourado J, Lago P, Cabral J, Marcos-Pinto R, Salgueiro P, Almeida CR, Carvalho S, Fonseca S, Lima M, Vilanova M, Dinis-Ribeiro M, Reis CA, Pinho SS
Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis. Human molecular genetics 23: 2416-27, 2014. [Article] 
 doi: 10.1093/hmg/ddt632 PMID: 24334766.
 
36
6.4
15. de-Freitas-Junior JC, Carvalho S, Dias AM, Oliveira P, Cabral J, Seruca R, Oliveira C, Morgado-Díaz JA, Reis CA, Pinho SS
Insulin/IGF-I Signaling Pathways Enhances Tumor Cell Invasion through Bisecting GlcNAc N-glycans Modulation. An Interplay with E-Cadherin. PloS one 8: e81579, 2013. [Article] 
 doi: 10.1371/journal.pone.0081579 PMID: 24282611.
 
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@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
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