Salomé Pinho
Name: Salomé Pinho
E-mail: salomep@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


Salomé Pinho
Salomé Pinho
Member of
Investigador Auxiliar of Immunology, Cancer and Glycomedicine


Short CV
Salomé Pinho received her D.V.M. from the University of Porto in 2004 and developed her PhD research at the Institute of Molecular Pathology and Immunology of Univ. Porto (IPATIMUP) and at Boston Medical School, MA, USA from 2006 to 2009. She performed her postdoctoral work at IPATIMUP in the glycobiology and disease field. At present, she is Researcher (PI) at IPATIMUP/i3S and affiliated Professor at Faculty of Medicine at University of Porto. Her research activity is focused on the understanding of the role of post-translational modifications by glycosylation in the regulation of key proteins´ functions involved in cancer and in chronic inflammatory conditions, envisioning potential clinical applications. She is author of several publications in international peer-reviewed journals (as first and senior author) including Nature Reviews Cancer, Oncogene and Human Molecular Genetics. She supervises a research team composed by Post-Docs, PhD students, Master students and young researchers. She is the Principal Investigator of several national/international funded projects in the field of cancer and inflammatory diseases. She received the Young Investigator Award from the European Association for Cancer Research and is inventor of 2 patents.

Highlights
- To uncover the role of post-translational modifications by glycosylation in the regulation of pivotal proteins involved in the process of cancer cell invasion and metastases envisioning potential clinical applications.

- To identify novel molecular mechanisms and potential biomarkers, based in glycosylation modifications, that may underlie the pathogenesis of pre-cancerous diseases such as Inflammatory Bowel Disease. Potential therapeutic applications.

Supervisor of
Ana Almeida, PhD Student
Ana Dias, Junior Researcher
António Marinho, Research Consultant
Eduarda Gomes, Master Student (thesis)
Fernando Gonçalves, Visiting Researcher
Inês Alves, PhD Student
Manuel Vicente, PhD Student
Márcia Pereira, PhD Student
Maria Oliveira, Master Student (thesis)
Mariana Silva, PhD Student
Mariana Bronze, Visiting Researcher
Mário Jorge Dinis Ribeiro, Research Consultant
Paula Lago, Research Consultant
Ricardo Marcos-Pinto, Research Consultant

PI (running)

PI (closed)
First Author
 
C
IF
Glycosylation in cancer: mechanisms and clinical implications. Nature reviews. Cancer 15: 540-55, 2015. [Review] 
 doi: 10.1038/nrc3982 PMID: 26289314.
 
2. Pinho SS, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhães A, Gärtner F, Mendonfa AM, Isaji T, Gu J, Carneiro F, Seruca R, Taniguchi N, Reis CA
 PMID: 23671930.
 
3. Pinho SS, Carvalho S, Marcos-Pinto R, Magalhães A, Oliveira C, Gu J, Dinis-Ribeiro M, Carneiro F, Seruca R, Reis CA
Gastric cancer: adding glycosylation to the equation. Trends in molecular medicine 19: 664-76, 2013. [Review] 
 
4. Pinho SS, Carvalho S, Cabral J, Reis CA, Gärtner F
Canine tumors: a spontaneous animal model of human carcinogenesis. Translational research : the journal of laboratory and clinical medicine 159: 165-72, 2012. [Review] 
 
5. Pinho SS, Oliveira P, Cabral J, Carvalho S, Huntsman D, Gärtner F, Seruca R, Reis CA, Oliveira C
 
6. Pinho SS, Seruca R, Gärtner F, Yamaguchi Y, Gu J, Taniguchi N, Reis CA
Modulation of E-cadherin function and dysfunction by N-glycosylation. Cellular and molecular life sciences : CMLS 68: 1011-20, 2011. [Review] 
 
 doi: 10.1093/hmg/ddp194 PMID: 19403558.
 
8. Pinho SS, Osório H, Nita-Lazar M, Gomes J, Lopes C, Gärtner F, Reis CA
Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochemical and biophysical research communications 379: 1091-6, 2009. [Article] 
 
9. Pinho SS, Reis CA, Gärtner F, Alpaugh ML
 
10. Pinho SS, Matos AJ, Lopes C, Marcos NT, Carvalheira J, Reis CA, Gärtner F
 
Senior Author
 
C
IF
1. Dias AM, Correia A, Pereira MS, Almeida CR, Alves I, Pinto V, Catarino TA, Mendes N, Leander M, Oliva-Teles MT, Maia L, Delerue-Matos C, Taniguchi N, Lima M, Pedroto I, Marcos-Pinto R, Lago P, Reis CA, Vilanova M, Pinho SS
Metabolic control of T cell immune response through glycans in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America 115: E4651-E4660, 2018. [Article] 
 
Glycans as Key Checkpoints of T Cell Activity and Function. Frontiers in immunology 9: 2754, 2018. [Review] 
 
3. de-Freitas-Junior JCM, Andrade-da-Costa J, Silva MC, Pinho SS
Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression. International journal of molecular sciences 18: ., 2017. [Review] 
 
4. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gärtner F, Sanches JM, Ruppert T, Miyoshi E, Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Reis CA, Pinho SS
 
5. Carvalho S, Oliveira T, Bartels MF, Miyoshi E, Pierce M, Taniguchi N, Carneiro F, Seruca R, Reis CA, Strahl S, Pinho SS
 
6. Dias AM, Almeida CR, Reis CA, Pinho SS
Studying T Cells N-Glycosylation by Imaging Flow Cytometry. Methods in molecular biology (Clifton, N.J.) 1389: 167-76, 2016. [] 
 
7. Bassagañas S, Carvalho S, Dias AM, Pérez-Garay M, Ortiz MR, Figueras J, Reis CA, Pinho SS, Peracaula R
 
8. Dias AM, Dourado J, Lago P, Cabral J, Marcos-Pinto R, Salgueiro P, Almeida CR, Carvalho S, Fonseca S, Lima M, Vilanova M, Dinis-Ribeiro M, Reis CA, Pinho SS
 doi: 10.1093/hmg/ddt632 PMID: 24334766.
 
9. de-Freitas-Junior JC, Carvalho S, Dias AM, Oliveira P, Cabral J, Seruca R, Oliveira C, Morgado-Díaz JA, Reis CA, Pinho SS
 
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