Ana Magalhães
Name: Ana Magalhães
Academic Degree: PhD

Ana Magalhães
Ana Magalhães
Member of
Affiliated Researcher of Glycobiology in Cancer

Short CV

Ana Magalhães graduated in Biochemistry (2005) and holds a PhD in Biomedicine (2011) by University of Porto. She got trained in proteomics at the BRC-Centre of Excellence of the European Union (Hungary), in Proximity Ligation Assays at Uppsala University (Sweden), in cancer glycobiology at the Institute of Molecular Pathology and Immunology of University of Porto (Portugal) and in bacterial adhesion and pathogen adaptation at Umea University (Sweden).
Ana co-authored more than 50 scientific articles, including highly prestigious journals such as Cancer Cell, PNAS, Nature Cell Biology, Developmental Cell and J Biol Chem. Her publications have received more than 2400 citations (H-index 29). She has successfully complete the supervision of 4 PhD and 6 MSc students, as main or co-supervisor. All these dissertations articulate fundamental and clinical research. 
At present, Ana is an Assistant Professor of Biochemistry at ICBAS- Scholl of Medicine and Biomedical Science and Investigator at i3S - University of Porto and her main research interests are focused on the mechanistic roles of proteoglycans in cancer-extracellular matrix dynamics and cell communication and signaling.

Identification of Syndecan-4 functional role in Helicobacter pylori adhesion and injection of virulence factors.

Glycophenotype characterization of human gastric mucosas representing different stages of the gastric carcinogenic cascade. We aim to find combinations of glycans that are differently expressed according to disease stage and to identify glycoforms selected by gastric cancer cells.

Understanding of the biological relevance of sialylated glycan structures in modulating gastric cancer cell behaviour and putative involvement in gastric carcinogenesis.

Designing of novel therapeutic strategies to prevent bacterial binding which explore the H. pylori-host glycans interactions.

Supervisor of
Ana Ribeiro, Master Student (theoretical phase)
MSc student
Catarina Marques, PhD Student
PhD student

PI (running)

PI (closed)
First Author
The role of O-glycosylation in human disease. Molecular aspects of medicine 79: 100964, 2021. [Review] 
Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer cell 31: 733-735, 2017. [Editorial Material] 
3. Magalhães A, Rossez Y, Robbe-Masselot C, Maes E, Gomes J, Shevtsova A, Bugaytsova J, Borén T, Reis CA
 doi: 10.1038/srep25575 PMID: 27161092.
4. Magalhães A, Mereiter S, Reis C
5. Magalhães A, Marcos-Pinto R, Nairn AV, Dela Rosa M, Ferreira RM, Junqueira-Neto S, Freitas D, Gomes J, Oliveira P, Santos MR, Marcos NT, Xiaogang W, Figueiredo C, Oliveira C, Dinis-Ribeiro M, Carneiro F, Moremen KW, David L, Reis CA
Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852: 1928-39, 2015. [Article] 
Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 43: 611-8, 2010. [Review] 
 PMID: 20521012.
7. Magalhães A, Ismail MN, Reis CA
Sweet receptors mediate the adhesion of the gastric pathogen Helicobacter pylori: glycoproteomic strategies. Expert review of proteomics 7: 307-10, 2010. [Editorial Material] 
 doi: 10.1586/epr.10.18 PMID: 20536299.
8. Magalhães A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osório H, David L, Le Pendu J, Haas R, Dell A, Borén T, Reis CA
9. Magalhães A, Marcos N T, Carvalho A S, David L, Figueiredo C, Bastos J, David G, Reis C
Senior Author
1. Marques C, Poças J, Gomes C, Faria-Ramos I, Reis CA, Vivès RR, Magalhães A
2. Marques C, Reis CA, Vivès RR, Magalhães A
3. Faria-Ramos I, Poças J, Marques C, Santos-Antunes J, Macedo G, Reis CA, Magalhães A
4. Matos R, Fonseca KL, Mereiter S, Maceiras AR, Gomes J, Vilaplana C, Gartner F, Rodrigues PNS, Reis CA, Saraiva M, Magalhães A
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