RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH
 
Ana Magalhães
Name: Ana Magalhães
E-mail: amagalhaes@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


Ana Magalhães
Ana Magalhães
Member of
Researcher of Glycobiology in Cancer


Short CV
Ana Magalhães is BSc in Biochemistry by the University of Porto (2005) and PhD in Biomedicine by the Medical Faculty of University of Porto (2011), with the supervision of Celso Reis (Ipatimup) and Thomas Borén (Umeå University, Sweden). Ana Magalhães is currently a post-doc at the Glycobiology in Cancer group, focused on identifying key enzymatic steps responsible for the gastric mucosa glycosylation remodeling observed during gastric carcinogenesis and on disclosing the structural-functional roles of glycans in modulating gastric cell tumorigenic potential. Ana Magalhães is co-author of 24 peer reviewed publications (H-index 10) and one book chapter.
Ana Magalhaes has participated in 7 Research Projects financed by national and international institutions and she is also the co-inventor of 1 registered international patent. (http://orcid.org/0000-0003-4863-6668).

Highlights
Identification of Syndecan-4 functional role in Helicobacter pylori adhesion and injection of virulence factors.

Glycophenotype characterization of human gastric mucosas representing different stages of the gastric carcinogenic cascade. We aim to find combinations of glycans that are differently expressed according to disease stage and to identify glycoforms selected by gastric cancer cells.

Understanding of the biological relevance of sialylated glycan structures in modulating gastric cancer cell behaviour and putative involvement in gastric carcinogenesis.

Designing of novel therapeutic strategies to prevent bacterial binding which explore the H. pylori-host glycans interactions.

Supervisor of
Juliana Poças, Fellow
Mariana Ferreira, Master Student (thesis)

PI (running)
"GLYcanMATRIX .: Compreender a dinâmica dos glicanos das células de cancro e matriz extracelular como nova estratégia de intervenção na progressão tumoral"
"PYLORIBINDERS-Tratamento/diagnóstico da infecção gástrica utilizando biomaterias específicos para a Helicobacter pylori sem recurso a antibióticos."

PI (closed)
"SwetMic-Helicobacter pylori entrapment using "sweet" microsponges: a new alternative for gastric infection treatment"
First Author
 
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IF
1. Magalhães A, Duarte HO, Reis CA
Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer cell 31: 733-735, 2017. [Editorial Material] 
 doi: 10.1016/j.ccell.2017.05.012 PMID: 28609653.
 
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22.8
2. Magalhães A, Rossez Y, Robbe-Masselot C, Maes E, Gomes J, Shevtsova A, Bugaytsova J, Borén T, Reis CA
Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding. Scientific reports 6: 25575, 2016. [Article] 
 doi: 10.1038/srep25575 PMID: 27161092.
 
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4.3
3. Magalhães A, Mereiter S, Reis C
Reciprocal Modulation of Terminal Sialylation and Bisecting N-Glycans: A New Axis of Cancer-Cell Glycome Regulation? The Journal of biological chemistry 291: 8308, 2016. [Letter] 
 doi: 10.1074/jbc.L116.722462 PMID: 27060175.
 
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4.1
4. Magalhães A, Marcos-Pinto R, Nairn AV, Dela Rosa M, Ferreira RM, Junqueira-Neto S, Freitas D, Gomes J, Oliveira P, Santos MR, Marcos NT, Xiaogang W, Figueiredo C, Oliveira C, Dinis-Ribeiro M, Carneiro F, Moremen KW, David L, Reis CA
Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852: 1928-39, 2015. [Article] 
 doi: 10.1016/j.bbadis.2015.07.001 PMID: 26144047.
 
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5. Magalhães A, Reis CA
Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 43: 611-8, 2010. [Review] 
 PMID: 20521012.
 
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6. Magalhães A, Ismail MN, Reis CA
Sweet receptors mediate the adhesion of the gastric pathogen Helicobacter pylori: glycoproteomic strategies. Expert review of proteomics 7: 307-10, 2010. [Editorial Material] 
 doi: 10.1586/epr.10.18 PMID: 20536299.
 
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7. Magalhães A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osório H, David L, Le Pendu J, Haas R, Dell A, Borén T, Reis CA
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa. Glycobiology 19: 1525-36, 2009. [Article] 
 doi: 10.1093/glycob/cwp131 PMID: 19706747.
 
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8. Magalhães A, Marcos N T, Carvalho A S, David L, Figueiredo C, Bastos J, David G, Reis C
Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells FEMS immunology and medical microbiology I: 1-10, 2009. [Article] 
 doi: 10.1111/j.1574-695X.2009.00569.x PMID: 19519784.
 
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Senior Author
 
C
IF
@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
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