1. Vasconcelos MH, Caires HR, Abols A, Xavier CPR, Line A

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 47: 100647, 2019. [Review] 

 doi: 10.1016/j.drup.2019.100647 PMID: 31704541.

 

2. Vasconcelos MH

Special Issue: New Approaches to Counteract Drug Resistance in Cancer. Molecules (Basel, Switzerland) 22: 1, 2016. [Editorial Material] 

 doi: 10.3390/molecules22010006 PMID: 28025535.

 

3. Vasconcelos MH, Maia LF, Sousa C, Beleza SS, Guimarães JE

Evidence for a specific intracellular localization of an antisense oligonucleotide in k562 cells. Journal of pharmacological sciences 99: 105-8, 2005. [Article] 

 PMID: 16141637.

 

4. Vasconcelos MH, Beleza SS, Quirk C, Maia LF, Sambade C, Guimarães JE

Limited synergistic effect of antisense oligonucleotides against bcr-abl and transferrin receptor mRNA in leukemic cells in culture. Cancer letters 152: 135-43, 2000. [Article] 

 PMID: 10773404.

 

1. Assaraf YG, Brozovic A, Gonçalves AC, Jurkovicova D, Line A, Machuqueiro M, Saponara S, Sarmento-Ribeiro AB, Xavier CPR, Vasconcelos MH

The multi-factorial nature of clinical multidrug resistance in cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 46: 100645, 2019. [Review] 

 doi: 10.1016/j.drup.2019.100645 PMID: 31585396.

 

2. Teixeira A, DaCunha DC, Barros L, Caires HR, Xavier CPR, Ferreira ICFR, Vasconcelos MH

Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 cells by increasing the p53 levels and altering the cell cycle profile. Food & function 10: 3188-3197, 2019. [Article] 

 doi: 10.1039/c8fo02466a PMID: 31165800.

 

3. Pereira JM, Peixoto V, Teixeira A, Sousa D, Barros L, Ferreira ICFR, Vasconcelos MH

Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 118: 635-644, 2018. [Article] 

 doi: 10.1016/j.fct.2018.06.006 PMID: 29883784.

 

4. Magalhães DB, Castro I, Lopes-Rodrigues V, Pereira JM, Barros L, Ferreira ICFR, Xavier CPR, Vasconcelos MH

Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis. Food & function 9: 3134-3142, 2018. [Article] 

 doi: 10.1039/c8fo00446c PMID: 29790547.

 

5. Bizarro A, Sousa D, Lima RT, Musso L, Cincinelli R, Zuco V, De Cesare M, Dallavalle S, Vasconcelos MH

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors. Molecules (Basel, Switzerland) 23: ., 2018. [Article] 

 doi: 10.3390/molecules23020407 PMID: 29438315.

 

6. Castro I, Lopes-Rodrigues V, Xavier CPR, Vasconcelos MH

gamma-H2AX, CYP3A and CYP2J2 overexpression in a drug-resistant acute myeloid leukemia cell line Free radical biology & medicine 120: S84-S84, 2018. [Meeting Abstract] 

 doi: 10.1016/j.freeradbiomed.2018.04.278.

 

7. Magalhães DB, Castro I, Lopes-Rodrigues V, Pereira JM, Barros L, Ferreira ICFR, Xavier CPR, Vasconcelos MH

Melissa Officinalis L. ethanolic extract interferes with cell cycle and induces apoptosis of non-small cell lung cancer cells Free radical biology & medicine 120: S143-S143, 2018. [Meeting Abstract] 

 doi: 10.1016/j.freeradbiomed.2018.04.472.

 

8. Pereira JM, Peixoto V, Teixeira A, Sousa D, Barros L, Ferreira ICFR, Vasconcelos MH

Achillea millefolium L. hydroethanolic extract has phenolic compounds and inhibits the growth of human tumor cell lines Free radical biology & medicine 120: S145-S145, 2018. [Meeting Abstract] 

 doi: 10.1016/j.freeradbiomed.2018.04.477.

 

9. Teixeira A, DaCunha DC, Caires HR, Xavier CPR, Barros L, Ferreira ICFR, Vasconcelos MH

Eucalyptus globulus Labill. decoction extract inhibits the growth of human tumor cell lines Free radical biology & medicine 120: S144-S144, 2018. [Meeting Abstract] 

 doi: 10.1016/j.freeradbiomed.2018.04.473.

 

10. Lopes-Rodrigues V, Di Luca A, Mleczko J, Meleady P, Henry M, Pesic M, Cabrera D, van Liempd S, Lima RT, O'Connor R, Falcon-Perez JM, Vasconcelos MH

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles. Scientific reports 7: 44541, 2017. [Article] 

 doi: 10.1038/srep44541 PMID: 28303926.

 

11. Lopes-Rodrigues V, Oliveira A, Correia-da-Silva M, Pinto M, Lima RT, Sousa E, Vasconcelos MH

A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells. Bioorganic & medicinal chemistry 25: 581-596, 2017. [Article] 

 doi: 10.1016/j.bmc.2016.11.023 PMID: 27908756.

 

12. Lopes-Rodrigues V, Sousa E, Vasconcelos MH

Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives. Pharmaceuticals (Basel, Switzerland) 9: 1, 2016. [Review] 

 doi: 10.3390/ph9040071 PMID: 27834897.

 

13. Lopes-Rodrigues V, Di Luca A, Sousa D, Seca H, Meleady P, Henry M, Lima RT, O'Connor R, Vasconcelos MH

Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells. Biochimica et biophysica acta 1860: 618-27, 2016. [Article] 

 doi: 10.1016/j.bbagen.2015.12.011 PMID: 26708992.

 

14. Reis FS, Sousa D, Barros L, Martins A, Morales P, Ferreira IC, Vasconcelos MH

Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 90: 45-54, 2016. [Article] 

 doi: 10.1016/j.fct.2016.02.005 PMID: 26854920.

 

15. Xavier CP, Pesic M, Vasconcelos MH

Understanding Cancer Drug Resistance by Developing and Studying Resistant Cell Line Models. Current cancer drug targets 16: 226-37, 2016. [Article] 

 PMID: 26563882.

 

16. Lima RT, Sousa D, Paiva AM, Palmeira A, Barbosa J, Pedro M, Pinto MM, Sousa E, Vasconcelos MH

Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells. Molecules (Basel, Switzerland) 21: 1343, 2016. [Article] 

 doi: 10.3390/molecules21101343 PMID: 27735867.

 

17. Pereira JM, Lopes-Rodrigues V, Xavier CP, Lima MJ, Lima RT, Ferreira IC, Vasconcelos MH

An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells. Molecules (Basel, Switzerland) 21: ., 2016. [Article] 

 doi: 10.3390/molecules21050595 PMID: 27164073.

 

18. Lopes-Rodrigues V, Di Luca A, Sousa D, Seca H, Meleady P, Henry M, Lima RT, O'Connor R, Vasconcelos MH

Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells Data in Brief 6: 1023–1027, 2016. [Article; Data Paper] 

 doi: 10.1016/j.dib.2016.02.004.

 

19. Vasconcelos MH

Special Issue: New Approaches to Counteract Drug Resistance in Cancer. Molecules (Basel, Switzerland) 22: 1, 2016. [Editorial Material] 

 doi: 10.3390/molecules22010006 PMID: 28025535.

 

20. Reis FS, Morales P, Ferreira ICFR, Vasconcelos MH

Mushrooms as a Source of Compounds that Induce Programmed Cell Death in Tumour Cells Recent Progress in Medicinal Plants 43: ., 2016. [] 

.

 

21. Sousa D, T Lima R, Vasconcelos H

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles Trends in molecular medicine  595-608, 2015. [Review] 

 doi: 10.1016/j.molmed.2015.08.002.

 

22. Reis FS, Lima RT, Morales P, Ferreira IC, Vasconcelos MH

Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells. Molecules (Basel, Switzerland) 20: 17872-82, 2015. [Article] 

 doi: 10.3390/molecules201017872 PMID: 26426001.

 

23. Lopes-Rodrigues V, Seca H, Sousa D, Sousa E, Lima RT, Vasconcelos MH

The network of P-glycoprotein and microRNAs interactions. International journal of cancer 135: 253-63, 2014. [Review] 

 doi: 10.1002/ijc.28500 PMID: 24122334.

 

24. Seca H, Lima RT, Almeida GM, Sobrinho-Simoes M, Bergantim R, Guimaraes JE, Vasconcelos MH

Effect of miR-128 in DNA Damage of HL-60 Acute Myeloid Leukemia Cells. Current pharmaceutical biotechnology 15: 492-502, 2014. [Article] 

 PMID: 24846063.

 

25. Lima M. João, Sousa D, Lima RT, Carvalho Ana Maria, Ferreira I.C.F.R., Vasconcelos M H

Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell line. Industrial Crops and Products 59: 149-153, 2014. [Article] 

 doi: 10.1016/j.indcrop.2014.05.009.

 

26. Oliveira M, Reis FS, Sousa D, Tavares C, Lima RT, Ferreira IC, Santos TD, Vasconcelos MH

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle. Food & function 5: 1389-94, 2014. [Article] 

 doi: 10.1039/c4fo00258j PMID: 24892846.

 

27. Santos T, Oliveira M, Sousa D, Lima R T, Martins A, Ferreira I, Vasconcelos M H

Suillus luteus methanolic extract inhibits proliferation and increases expression of p-H2A.X in a non-small cell lung cancer cell line Journal of Functional Foods 6: 100-106, 2014. [Article] 

 doi: 10.1016/j.ff.2013.09.023.

 

28. Seca H, Lima RT, Vasconcelos MH

miRNAs in cancer drug resistance and drug sensitivity MicroRNAs: key regulators of oncogenesis. Editor: S. Babashah. Publisher: Springer International Publishing Switzerland  11, 2014. [] 

.

 

29. Seca H, Lima RT, Lopes-Rodrigues V, Guimaraes JE, Almeida GM, Vasconcelos MH

Targeting miR-21 Induces Autophagy and Chemosensitivity of Leukemia Cells. Current drug targets 14: 1135-43, 2013. [Article] 

 PMID: 23834154.

 

30. Queiroz MJ, Peixoto D, Calhelha RC, Soares P, Dos Santos T, Lima RT, Campos JF, Abreu RM, Ferreira IC, Vasconcelos MH

New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death. European journal of medicinal chemistry 69: 855-62, 2013. [Article] 

 doi: 10.1016/j.ejmech.2013.09.023 PMID: 24121236.

 

31. Santos T, Tavares C, Sousa D, Vaz J, Calhelha R C, Martins A, Almeida G M, Ferreira I, Vasconcelos M H

Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line Food Research International  1, 2013. [Article] 

 doi: 10.1016/j.foodres.2013.05.037.

 

32. Lima RT, Seca H, Palmeira A, Fernandes MX, Castro F, Correia-da-Silva M, Nascimento MS, Sousa E, Pinto M, Vasconcelos MH

Sulfated small molecules targeting eBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA. Chemical biology & drug design 81: 631-44, 2013. [Article] 

 doi: 10.1111/cbdd.12109 PMID: 23350710.

 

33. Lima Raquel T., Nascimento M . S. José, Vasconcelos M. Helena

EBV-associated cancers: Strategies for targeting the virus Microbial pathogens and strategies for combating them: science, technology and education 3: 1608-1618, 2013. [] 

.

 

34. Vaz J, Ferreira I CFR, Tavares C, Almeida G M, Martins A, Vasconcelos M H

Suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line Food Chemistry  1, 2012. [Article] 

 doi: 10.1016/j.foodchem.2012.04.127.

 

35. Vaz J A, Almeida G, Ferreira I C.F.R., Martins A, Vasconcelos M H

Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: identification of phenolic acids with cytotoxic potential Food Chemistry 132: 482-486, 2012. [Article] 

 doi: 10.1016/j.foodchem.2011.11.031.

 

36. Lima RT, Busacca S, Almeida GM, Gaudino G, Fennell DA, Vasconcelos MH

MicroRNA regulation of core apoptosis pathways in cancer. European journal of cancer (Oxford, England : 1990) 47: 163-74, 2011. [Review] 

 doi: 10.1016/j.ejca.2010.11.005 PMID: 21145728.

 

37. Queiroz MJ, Calhelha RC, Vale-Silva LA, Pinto E, Almeida GM, Vasconcelos MH

Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis. European journal of medicinal chemistry 46: 236-40, 2011. [Article] 

 doi: 10.1016/j.ejmech.2010.11.009 PMID: 21138784.

 

38. Seca H, Lima RT, Guimarães JE, Helena Vasconcelos M

Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib. Hematology (Amsterdam, Netherlands) 16: 100-8, 2011. [Article] 

 doi: 10.1179/102453311X12940641877803 PMID: 21418741.

 

39. Lima RT, Seca H, Brás S, Nascimento MS, Vasconcelos MH

Treatment of Akata EBV-positive cells with doxorubicin causes more EBV reactivation than treatment with etoposide. Chemotherapy 57: 195-203, 2011. [Article] 

 doi: 10.1159/000323627 PMID: 21540588.

 

40. Palmeira A, Sousa E, Fernandes MX, Pinto MM, Vasconcelos M H

Multidrug resistance reversal effects of aminated thioxanthones and interaction with cytochrome P450 3A4. Journal of Pharmacy & Pharmaceutical Sciences 3: 31-45, 2011. [Article] 

.

 

41. Lima RT, Seca H, Soares P, Nascimento MS, Vasconcelos MH

EBV interferes with the sensitivity of Burkitt lymphoma Akata cells to etoposide. Journal of cellular biochemistry 112: 200-10, 2011. [Article] 

 doi: 10.1002/jcb.22920 PMID: 21069730.

 

42. Palmeira A, Paiva A, Sousa E, Seca H, Almeida GM, Lima RT, Fernandes MX, Pinto M, Vasconcelos MH

Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone. Chemical biology & drug design 76: 43-58, 2010. [Article] 

 doi: 10.1111/j.1747-0285.2010.00978.x PMID: 20456373.

 

43. Queiroz MJ, Calhelha RC, Vale-Silva LA, Pinto E, Lima RT, Vasconcelos MH

Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle. European journal of medicinal chemistry 45: 5628-34, 2010. [Article] 

 doi: 10.1016/j.ejmech.2010.09.014 PMID: 20926160.

 

44. Seca H, Almeida GM, Guimarães JE, Vasconcelos MH

miR signatures and the role of miRs in acute myeloid leukaemia. European journal of cancer (Oxford, England : 1990) 46: 1520-1527, 2010. [Review] 

 doi: 10.1016/j.ejca.2010.03.031 PMID: 20413298.

 

45. Lima R T, Guimarães JE, Vasconcelos MH

Overcoming K562Dox resistance to STI571 (Gleevec) by downregulation of P-gp expression using siRNAs Cancer Therapy 5: 67-76, 2007. [] 

.

 

46. Lima RT, Martins LM, Guimarães JE, Sambade C, Vasconcelos MH

Chemosensitization effects of XIAP downregulation in K562 leukemia cells. Journal of chemotherapy (Florence, Italy) 18: 98-102, 2006. [Article] 

 PMID: 16572900.

 

47. Lima RT, Martins LM, Guimarães JE, Sambade C, Vasconcelos MH

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells. Cancer gene therapy 11: 309-16, 2004. [Article] 

 doi: 10.1038/sj.cgt.7700706 PMID: 15031723.