Leonor David
Name: Leonor David
E-mail: ldavid@ipatimup.pt
Academic Degree: Doctor of philosophy

Leonor David
Leonor David
Member of
Consultant of Ipatimup Diagnostics

Short CV
Leonor David was born in Porto, Portugal, in 1955. Leonor David is a Pathologist and Full Professor of Pathology at the Medical Faculty of Porto, Porto, Portugal. She received a degree in medicine and earned her Ph.D. degree from the Medical Faculty of Porto, Portugal, in 1979 and 1993, respectively. She did part of her Ph.D. and postdoctoral research at the Radium Hospital in Oslo, Norway and at the University of Copenhagen, Denmark. Her main interest is focused on mucins and mucin glycosylation in gastric carcinogenesis. She is also particularly interested in the regulation of events leading to intestinal metaplasia. Leonor David participated in the organizing committee of several international meetings on cancer and mucin/mucin glycosylation, published over 100 papers in journals with peer-review, wrote 6 book chapters, is Member of the Council of the European Association for Cancer Research. Leonor David is president of ASPIC (Portuguese Association for Cancer Research).

Characterization and regulation of mucin glycosylation in carcinogenesis processes using different approaches, from glycopeptide characterization using Proximity Ligation Assays (PLA), to zinc-finger strategies to manipulate CDX2 dependent glycoproteome modifications, to classical approaches like luciferase assays, ChIP assays and immunofluorescence. Recently I have focused on the study of MUC16 mucin and its glycoforms in different cancer models, on production and characterization of MUC16 monoclonal antibodies and in dissecting the role of MUC16-mesothelin interaction in cancer progression.

Supervisor of
Luísa Melo, Project Manager
Ricardo Coelho, PhD Student

PI (running)

PI (closed)
First Author
Senior Author
1. Ricardo S, Marcos-Silva L, Valente C, Coelho R, Gomes R, David L
Mucins MUC16 and MUC1 are major carriers of SLe(a) and SLe(x) in borderline and malignant serous ovarian tumors. Virchows Archiv : an international journal of pathology 468: 715-22, 2016. [Article] 
Mucin carriers of TF in ovarian cancer. Journal of cancer research and clinical oncology 142: 1867-8, 2016. [Letter] 
3. Ricardo S, Marcos-Silva L, Pereira D, Pinto R, Almeida R, Söderberg O, Mandel U, Clausen H, Felix A, Lunet N, David L
4. Pinto R, Barros R, Pereira-Castro I, Mesquita P, da Costa LT, Bennett EP, Almeida R, David L
CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia. Laboratory investigation; a journal of technical methods and pathology 95: 718-27, 2015. [Article] 
5. Silva ML, Gutiérrez E, Rodríguez JA, Gomes C, David L
Construction and validation of a Sambucus nigra biosensor for cancer-associated STn antigen. Biosensors & bioelectronics 57: 254-61, 2014. [Article] 
6. Carrilho C, Gouveia P, Yokohama H, Lopes JM, Lunet N, Ferro J, Ismail M, Walboomers J, Sobrinho-Simões M, David L
Human papillomaviruses in intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva: a study from Mozambique. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 22: 566-8, 2013. [Article] 
7. Pinto R, Carvalho AS, Conze T, Magalhães A, Picco G, Burchell JM, Taylor-Papadimitriou J, Reis CA, Almeida R, Mandel U, Clausen H, Söderberg O, David L
Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation. Journal of cellular and molecular medicine 16: 1474-84, 2012. [Article] 
Alterations in glycosylation as biomarkers for cancer detection. Journal of clinical pathology 63: 322-9, 2010. [Review] 
9. Silva LM, Carvalho AS, Guillon P, Seixas S, Azevedo M, Almeida R, Ruvoën-Clouet N, Reis CA, Le Pendu J, Rocha J, David L
10. Azevedo M, Eriksson S, Mendes N, Serpa J, Figueiredo C, Resende LP, Ruvoën-Clouet N, Haas R, Borén T, Le Pendu J, David L
 doi: 10.1002/path.2363 PMID: 18498114.
11. Serpa J, Mesquita P, Mendes N, Oliveira C, Almeida R, Santos-Silva F, Reis CA, LePendu J, David L
12. Pinto de Sousa J, David L
Role of immunohistochemical expression of MUC5B in gastric carcinoma. In: Handbook of immunohistochemistry and in situ hybridization of human carcinomas. Handbook of immunohistochemistry and in situ hybridization of human carcinomas 4 4: 191-194, 2006. [] 
13. Mesquita P, Raquel A, Nuno L, Reis CA, Silva LF, Serpa J, Van Seuningen I, Barros H, David L
 PMID: 17078204.
14. Almeida R, Almeida J, Shoshkes M, Mendes N, Mesquita P, Silva E, Van Seuningen I, Reis CA, Santos-Silva F, David L
 doi: 10.1002/path.1861 PMID: 16278805.
15. Carrilho C, Cirnes L, Alberto M, Buane L, Mendes N, David L
16. Carrilho C, Alberto M, Buane L, David L
 PMID: 15138927.
17. Serpa J, Mendes N, Reis CA, Santos Silva LF, Almeida R, Le Pendu J, David L
 doi: 10.1042/BJ20040803 PMID: 15250822.
18. Mesquita P, Almeida R, Van Seuningen I, David L
 PMID: 15316331.
19. Reis CA, Teixeira A, David L
Role of mucins in Helicobacter pylori adhesion to the gastric mucosa. Helicobacter 9: 181; author reply 181-2, 2004. [Letter] 
20. Serpa J, Lunet N, Mendes N, Barros H, David L
Lewis and Secretor status and Helicobacter pylori eradication. Epidemiology and infection 132: 997-8; author reply 998-9, 2004. [Letter] 
 PMID: 15473165.
21. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolós C, David L
 doi: 10.1002/path.1246 PMID: 12474224.
22. Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, Van Seuningen I, David L
23. Simpson RH, Prasad AR, Lewis JE, Skálová A, David L
Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. The American journal of surgical pathology 27: 1070-9, 2003. [Article] 
 PMID: 12883239.
24. Mesquita P, Peixoto AJ, Seruca R, Hanski C, Almeida R, Silva F, Reis C, David L
 PMID: 12490305.
25. Silva F, Carvalho F, Peixoto A, Teixeira A, Almeida R, Reis C, Bravo LE, Realpe L, Correa P, David L
26. Serpa J, Almeida R, Oliveira C, Silva FS, Silva E, Reis C, Le Pendu J, Oliveira G, Ribeiro LM, David L
27. Carrilho C, Gouveia P, Cantel M, Alberto M, Buane L, David L
 PMID: 12908520.
28. Silva F, Carvalho F, Peixoto A, Seixas M, Almeida R, Carneiro F, Mesquita P, Figueiredo C, Nogueira C, Swallow DM, Amorim A, David L
MUC1 gene polymorphism in the gastric carcinogenesis pathway. European journal of human genetics : EJHG 9: 548-52, 2001. [Article] 
29. Carrilho C, Cantel M, Gouveia P, David L
 PMID: 10993278.
30. Garcia E, Carvalho F, Amorim A, David L
MUC6 gene polymorphism in healthy individuals and in gastric cancer patients from northern Portugal. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 6: 1071-4, 1997. [Article] 
 PMID: 9419405.
31. Marinho A, Moura A, Baptista M, Macedo G, Pimenta A, David L
Granular cell tumour and leiomyomatosis of the esophagus--a non-coincidental association? Pathology, research and practice 192: 492-5, 1996. [Article] 
 PMID: 8832756.
 PMID: 8826873.
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