Ipatimup

RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH

Carla Oliveira

Name: Carla Oliveira

E-mail: carlaol@ipatimup.pt

Carla Oliveira

Member of

Researcher of Expression Regulation in Cancer

Consultant of Ipatimup Diagnostics

Short CV

Carla Oliveira, BSc, PhD

2015-present Group Leader/Principal Investigator (tenure), Expression Regulation in Cancer Group, i3S Porto, PT

2013-present Group Leader/Principal Investigator (tenure), Expression Regulation in Cancer Group, Ipatimup, Porto, PT

2013-present Co-founder, Scientific Head and CEO, Bioinf2Bio Bioinformatics Company, Porto, PT

2006-present Affiliated Professor, Dept. Pathology, Fac. Medicine, Univ. Porto, PT

2005-present Consultant for gastric-cancer related syndromes, IPATIMUP Diagnostics, Porto, PT

2011-2012 Invited researcher, Max Planck Institute for Developmental Biology, Tubingen, DE (E. Isaurralde Lab)

2008-2012 Junior Group Leader, Ipatimup, Porto, PT (Ciência 2008 – FCT)

2005-2008 Team Leader, Ipatimup, Porto, PT (Agência de Inovação - FCT)

2004-2005 Post-doc Researcher, Univ. British Columbia, Vancouver, CA (D. Huntsman Lab)

2002-2003 Post-doc Researcher, Ipatimup, Porto, PT (R. Seruca Lab) & INSERM, Paris, FR (R. Hamelin Lab)

March-2002 GABBA PhD in Human Biology, Fac. Medicine, Univ. Porto, PT

2001-2002 Visiting Ph.D. student, Ipatimup, PT (R. Seruca Lab)

1999-2000 Ph.D. student, CIMR - Cambridge Institute for Medical Research (C. Caldas Lab), Cambridge Univ., UK

1997-1998 Research Fellowship recipient, Ipatimup-Institute of Molecular Pathology and Immunology UPorto, PT

1991-1996 Biochemistry Degree, Fac. Science and Technology, Univ. Coimbra, PT

In March2021

H-INDEX = 49 (SCOPUS/ResearcherID) or 60 (GoogleScholar)

PUBLICATIONS: 152 peer-reviewed articles with >10.000 (SCOPUS) or >15000 citations (GoogleScholar) in the fields of Human Genetics and Molecular Oncology;

Accumulated Impact Factor: >1.000,00

C. Oliveira is recognized internationally for her work in E-cadherin/CDH1-related diseases and hereditary cancer. She disclosed novel germline causes of Hereditary Gastrointestinal Cancer and defined somatic events in tumours with impact for patient management and therapy.

Her main scientific aim is to disclose the missing heritability in Hereditary Gastric Cancer. For this, her team is exploring the whole genome, with particular emphasis in the noncoding genome. She also aims at finding biomarkers with clinical utility for earlier detection of sporadic and hereditary gastric cancer and to disclose actionable genotype-phenotype relationships in these diseases. The social and economic impact of hereditary cancer is a transversal aspect in her research and she privileges the interaction with Patient’s associations, such as EVITA.

C. Oliveira has been a PI of 23 projects funded with >3.5M€ and team member in 17 projects with equivalent total budget. She independently raised additional 2.5M€ for human resources. She was invited speaker in >100 National and International conferences; she is Scientific and Executive Committee Member of the European Society of Human Genetics and its Portuguese sister society; National Representative of the European Reference Network ERN-GENTURIS on genetic tumour risk syndromes, and; the head the Hereditary Diffuse Gastric Cancer branch of the SolveRD (Solving Rare diseases) EU-Project. She is regular reviewer of National and International fellowship and grant applications. She successfully supervised 13 Masters and 13 PhD students to completion, 10 post-docs and recruited 3 junior project leaders (iFCT) for her team.

C. Oliveira’s group has also gained expertise and visibility in genomics and bioinformatics, due to active participation in international consortia and large European Projects including the European-wide research project SOLVE-RD – Solve Rare diseases; the Consortium GEUVADIS and GTEx; Several COST actions, as well as the Marie Sklodowska-Curie Innovative Training Networks ITN TRAIN-EV. The group has relevant roles in management and executive functions in the GenomePT National Infrastructure for genome sequencing and the 1 Million European Genomes project. Her team is multidisciplinary with strong background in oncobiology and genetics, and supported by technical expertise in molecular and cellular biology, NGS, bioinformatics and a strong link with hospitals and clinical professionals.

Highlights

The “EXPRESSION REGULATION IN CANCER” group aims, in the next three years, to identification cancer-associated expression regulatory mechanisms that impact early diagnosis, prognosis and chemotherapy-induced resistance in cancer.

Specific aims:
1. Identify the molecular basis of familial gastric cancer (HDGC and Familial Intestinal Gastric Cancer - FIGC);
2. Uncover somatic regulation in gastric cancer and its relationship with patients’ prognosis;
3. Optimize tools for early diagnosis of gastric cancer;
4. Uncover mechanisms involved in metastasis and chemotherapy-induced resistance using Epithelial-Mesenchymal-Epithelial transitions (EMT/MET) experimental models;
5. Unravel the role of mRNA mistranslation in human cancer.

Supervisor of

Alexandre Dias, Fellow
Research Fellowship (MSc)

Ana André, Lab Manager
Research Technician

Rita Matos, PhD Student

Ana Gonçalves, Collaborator
Visitor

Celina José, PhD Student

Diana Martins, External Researcher

Francisco Almeida, Master Student (thesis)

Joana Guerra, PhD Student

José Peláez, PhD Student

Liliana Sousa, PhD Student

Mafalda Santos, Junior Researcher
Junior Researcher

Marta Ferreira, PhD Student
PhD student

Pedro Ferreira, Researcher

Silvana Lobo, PhD Student
PhD student

PI (running)

GenomePT .: National Laboratory for Genome Sequencing and Analysis

Solve the Unsolved - Rare Diseases

3DChroMe: Solving the 3D Chromatin Structure Of CDH1 Locus To Identify Disease-Associated Mechanisms

PI (closed)

Long survival in patients with high-grade serous carcinoma of the ovary: a molecular and clinical study

Tackling cancer stem cells: a challenge and an opportunity to advance in anti-cancer therapy (CANCERSTEM)

Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases – a system analysis NETwork towards precision medicine (DOCnet)

Mapping genetic and phenotypic heterogeneity in HER2 positive cancers to anticipate and counteract resistance phenotypes.

Tumour secreted factors in EMT/non-EMT cells for invasion and metastization.

A 3D microarray platform for the high-throughput analysis of the role of the extracellular matrix in cancer-associated epithelial-to-mesenchymal transitions

Using NGS to uncover structural and regulatory variation in Gastric Cancer

TUMORTAG - Tumor-targeted nanoparticles for early diagnosis of gastric cancer

New E-cadherin RNAs: the dark side of a tumour suppressor gene

Mutated suppressor tRNAs as a therapeutic tool for cancer associated syndromes: HDGC as a model

Role of novel regulatory mechanisms in the loss of E-cadherin expression

Identification of molecular mechanisms underlying gastric cancer in families positive and negative for E-cadherin germline mutations

First Author

1. Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F

Familial gastric cancer: genetic susceptibility, pathology, and implications for management. The Lancet. Oncology 16: e60-e70, 2015. [Review]

doi: 10.1016/S1470-2045(14)71016-2 PMID: 25638682.

142

26.5

2. Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F

E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer. Progress in molecular biology and translational science 116: 337-59, 2013. [Review; Book Chapter]

doi: 10.1016/B978-0-12-394311-8.00015-7 PMID: 23481202.

3.1

3. Oliveira C, Seruca R, Hoogerbrugge N, Ligtenberg M, Carneiro F

Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC). European journal of human genetics : EJHG 21: ., 2013. [Editorial Material]

doi: 10.1038/ejhg.2012.247 PMID: 23443028.

4.2

4. Oliveira C, Senz J, Kaurah P, Pinheiro H, Sanges R, Haegert A, Corso G, Schouten J, Fitzgerald R, Vogelsang H, Keller G, Dwerryhouse S, Grimmer D, Chin SF, Yang HK, Jackson CE, Seruca R, Roviello F, Stupka E, Caldas C, Huntsman D

Germline CDH1 deletions in hereditary diffuse gastric cancer families. Human molecular genetics 18: 1545-55, 2009. [Article]

doi: 10.1093/hmg/ddp046 PMID: 19168852.

125

7.4

5. Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carriço R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmão L, Wen X, Cipriano MA, Yokota J, Carneiro F, Huntsman D, Seruca R

Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology 136: 2137-48, 2009. [Article]

doi: 10.1053/j.gastro.2009.02.065 PMID: 19269290.

103

12.9

6. Oliveira C, Seruca R, Carneiro F

Hereditary gastric cancer. Best practice & research. Clinical gastroenterology 23: 147-57, 2009. [Article]

doi: 10.1016/j.bpg.2009.02.003 PMID: 19414142.

2.5

7. Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha AF, Duval A, Hamelin R, Machado JC, Schwartz S, Carneiro F, Seruca R

KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. Oncogene 26: 158-63, 2007. [Article]

doi: 10.1038/sj.onc.1209758 PMID: 16953233.

131

6.4

8. Oliveira C, Seruca R, Carneiro F

Genetics, pathology, and clinics of familial gastric cancer. International journal of surgical pathology 14: 21-33, 2006. [Review]

PMID: 16501831.

109

1.0

9. Oliveira C, Velho S, Domingo E, Preto A, Hofstra RM, Hamelin R, Yamamoto H, Seruca R, Schwartz S

Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. Oncogene 24: 7630-4, 2005. [Article]

doi: 10.1038/sj.onc.1208906 PMID: 16007118.

6.9

10. Oliveira C, Moreira H, Seruca R, de Oliveira MC, Carneiro F

Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family. Virchows Archiv : an international journal of pathology 446: 181-4, 2005. [Article]

doi: 10.1007/s00428-004-1156-4 PMID: 15735979.

2.2

11. Oliveira C, Westra JL, Arango D, Ollikainen M, Domingo E, Ferreira A, Velho S, Niessen R, Lagerstedt K, Alhopuro P, Laiho P, Veiga I, Teixeira MR, Ligtenberg M, Kleibeuker JH, Sijmons RH, Plukker JT, Imai K, Lage P, Hamelin R, Albuquerque C, Schwartz S, Lindblom A, Peltomaki P, Yamamoto H, Aaltonen LA, Seruca R, Hofstra RM

Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. Human molecular genetics 13: 2303-11, 2004. [Article]

doi: 10.1093/hmg/ddh238 PMID: 15294875.

108

7.8

12. Oliveira C, de Bruin J, Nabais S, Ligtenberg M, Moutinho C, Nagengast FM, Seruca R, van Krieken H, Carneiro F

Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour. Oncogene 23: 2236-40, 2004. [Article]

doi: 10.1038/sj.onc.1207335 PMID: 14661064.

6.3

13. Oliveira C, Ferreira P, Nabais S, Campos L, Ferreira A, Cirnes L, Alves CC, Veiga I, Fragoso M, Regateiro F, Dias LM, Moreira H, Suriano G, Machado JC, Lopes C, Castedo S, Carneiro F, Seruca R

E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. European journal of cancer (Oxford, England : 1990) 40: 1897-903, 2004. [Article]

doi: 10.1016/j.ejca.2004.04.027 PMID: 15288293.

3.3

14. Oliveira C, Suriano G, Ferreira P, Canedo P, Kaurah P, Mateus R, Ferreira A, Ferreira AC, Oliveira MJ, Figueiredo C, Carneiro F, Keller G, Huntsman D, Machado JC, Seruca R

Genetic screening for familial gastric cancer. Hereditary Cancer in Clinical Practice 2: 51-64, 2004. []

doi: 10.1186/1897-4287-2-2-51 PMID: 20233471.

15. Oliveira C, Pinto M, Duval A, Brennetot C, Domingo E, Espín E, Armengol M, Yamamoto H, Hamelin R, Seruca R, Schwartz S

BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene 22: 9192-6, 2003. [Article]

doi: 10.1038/sj.onc.1207061 PMID: 14668801.

111

6.5

16. Oliveira C, Seruca R, Caldas C

Genetic screening for hereditary diffuse gastric cancer. Expert review of molecular diagnostics 3: 201-15, 2003. [Review]

doi: 10.1586/14737159.3.2.201 PMID: 12647996.

17. Oliveira C, Bordin MC, Grehan N, Huntsman D, Suriano G, Machado JC, Kiviluoto T, Aaltonen L, Jackson CE, Seruca R, Caldas C

Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. Human mutation 19: 510-7, 2002. [Article]

doi: 10.1002/humu.10068 PMID: 11968083.

116

6.9

18. Oliveira C, Seruca R, Seixas M, Sobrinho-Simões M

The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes. The American journal of pathology 153: 1211-9, 1998. [Article]

PMID: 9777952.

132

Senior Author

1. Pereira C, Ferreira D, Mendes N, Granja PL, Almeida GM, Oliveira C

Expression of CD44v6-Containing Isoforms Influences Cisplatin Response in Gastric Cancer Cells. Cancers 12: ., 2020. []

doi: 10.3390/cancers12040858 PMID: 32252293.

6.1 (*)

2. Lobo S, Pereira C, Almeida GM, Oliveira C

Investigating the role of CD44v6 in Gastric Cancer: development of exon v6 skipping models by CRISPR/Cas9 Medicine 99: -, 2020. [Meeting Abstract]

1.6 (*)

3. Jose CS, Monteiro AR, Andre A, Qamra A, Acuna-Hidalgo R, Tan P, Mundlos S, Oliveira C

CDH1 regulatory noncoding elements: a hidden master for tissue-specific E-cadherin expression European journal of human genetics : EJHG 28: 73-74, 2020. [Meeting Abstract]

3.7 (*)

4. Garcia-Pelaez J, Monteiro R, Sousa L, Pinheiro H, Castedo S, Garrido L, Teixeira M, Michils G, Bours V, de Putter R, Golmard L, Blanluet M, Colas C, Benusiglio P, Aretz S, Spier I, Huneburg R, Gieldon L, Schrock E, Holinski-Feder E, Steinke V, Calistri D, Tedaldi G, Ranzani G, Genuardi M, Silveira C, Silva I, Krajc M, Blatnik A, Novakovic S, Patino-Garcia A, Soto J, Lazaro C, Capella G, Brunet-Vidal J, Balmana J, Dominguez-Garrido E, Ligtenberg M, Fewings E, Fitzgerald R, Woodward E, Evans G, Hanson H, Lagerstedt-Robinson K, Bajalica-Lagercrantz S, Egas C, Martinez-Bouzas C, Dahan K, Feret D, Hoogerbrugge N, Tischkowitz M, Oliveira C

The first genotype-phenotype study on European carriers of CDH1 germline mutations European journal of human genetics : EJHG 28: 61-63, 2020. [Meeting Abstract]

3.7 (*)

5. Celina SJ, Ana MR, Aditi Q, Acuna-Hidalgo R, Patrick T, Mundlos S, Carla O

The role of CDH1 regulatory noncoding elements for E-cadherin expression Medicine 99: -, 2020. [Meeting Abstract]

1.6 (*)

6. Garcia-Pelaez J, Monteiro AR, Sousa L, Pinheiro H, Castedo S, Garrido L, Teixeira M, Michils G, Bours V, de Putter R, Golmard L, Blanluet M, Colas C, Benusiglio P, Aretz S, Spier I, Huneburg R, Gieldon L, Schrock E, Holinski-Feder E, Steinke V, Calistri D, Tedaldi G, Ranzani GN, Genuardi M, Silveira C, Silva I, Krajc M, Blatnik A, Novakovic S, Patino-Garcia A, Soto JL, Lazaro C, Capella G, Brunet-Vidal J, Balmana J, Dominguez-Garrido E, Ligtenberg M, Fewings E, Fitzgerald RC, Woodward ER, Evans G, Hanson H, Lagerstedt-Robinson K, Bajalica-Lagercrantz S, Egas C, Tejada MI, Martinez-Bouzas C, Merino S, Carrera S, Garcia-Bercina M, Dahan K, Feret D, Hoogerbrugge N, Tischkowitz M, Oliveira C

The first genotype-phenotype study of European carriers of CDH1 germline mutations Medicine 99: -, 2020. [Meeting Abstract]

1.6 (*)

7. Garrido L, Sousa L, Nercio T, Castro L, Leal R, Costa S, Magalhaes A, Pereira AF, Guimaraes R, Ferro L, Vilarinho L, Gullo I, Pinheiro H, Sousa S, Neto AP, Capela L, Caeiro C, Augusto I, Almeida D, Pinto G, Teixeira C, Devezas V, Macedo G, Fougo JL, Preto J, Barbosa J, Costa-Maia J, Baptista M, Fernandes S, Carneiro F, Castedo S, Oliveira C

A cost-effective model for the pathway of care of CDH1-related hereditary diffuse gastric cancer syndrome (HDGC) European journal of human genetics : EJHG 28: 624-625, 2020. [Meeting Abstract]

3.7 (*)

8. Pereira C, Ferreira M, Oliveira P, Carneiro F, Almeida GM, Oliveira C

The prognostic significance of E-cadherin in Gastric Cancer: an integrative approach based on patients' cohort and CRISPR-Cas9 engineered cell models Medicine 99: -, 2020. [Meeting Abstract]

1.6 (*)

9. Rocha S, Teles SP, Azevedo M, Oliveira P, Carvalho J, Oliveira C

Gastric Cancer Extracellular Vesicles Tune the Migration and Invasion of Epithelial and Mesenchymal Cells in a Histotype-Dependent Manner. International journal of molecular sciences 20: ., 2019. [Article]

doi: 10.3390/ijms20112608 PMID: 31141946.

4.6

10. Garrido L, Nercio T, Leal R, Guimaraes R, Ferro L, Vilarinho L, Costa S, Magalhaes A, Mesquita AS, Pereira AF, Gullo I, Pinheiro H, Sousa S, Carvalho B, Neto AP, Capela L, Teixeira C, Fareleira A, Devezas V, Macedo G, Preto J, Barbosa J, Baptista M, Pinto G, Damasceno M, Fougo JL, Costa-Maia J, Fernandes S, Carneiro F, Castedo S, Oliveira C

Genetic counselling in hereditary diffuse gastric cancer: economical and psycho-social impact European journal of human genetics : EJHG 27: 673-674, 2019. [Meeting Abstract]

3.7

11. Jose CS, Ferro A, Oliveira P, Carvalho J, Pinheiro H, Huntsman D, Acuna-Hidalgo R, Mundlos S, Oliveira C

CDH1 intronic Cis-Regulatory Elements control CDH1 gene tissue-specific expression European journal of human genetics : EJHG 27: 1609-1610, 2019. [Meeting Abstract]

3.7

12. Garrido L, Leal R, Aguiar A, Seixas S, Ferro L, Vilarinho L, Gullo I, Devezas V, Oliveira R, Fernandes S, Magalhaes A, Baptista M, Carneiro F, Castedo S, Oliveira C

The first CDH1 founder mutation in Portugal: Risk assessment and clinical management European journal of human genetics : EJHG 27: 1787-1787, 2019. [Meeting Abstract]

3.7

13. Matos R, Mesquita B, Oliveira P, Valente S, Pinheiro H, Carvalho J, Ferro A, Huntsman D, oliveira C

lntronic cis-regulatory elements regulate CDH1 gene expression and, function Medicine 98: ., 2019. [Meeting Abstract]

1.6

14. Lemos D, Oliveira P, Carvalho J, Jose CS, Oliveira C

Annotator: a novel custom tool for genomic variants annotation and classification European journal of human genetics : EJHG 27: 1033-1033, 2019. [Meeting Abstract]

3.7

15. Pelaez JG, Monteiro A, Sousa L, Castedo S, Michils G, Bours V, de Putter R, Golmard L, Blanluet M, Colas C, Benusiglio P, Aretz S, Spier I, Huneburg R, Gieldon L, Schrock E, Holinski-Feder E, Steinke V, Calistri D, Tedaldi G, Nadia-Ranzani G, Genuardi M, Silveira C, Krajc M, Blatnik A, Novakovic S, Patino-Garcia A, Soto J, Lazaro C, Capella G, Brunet-Vidal J, Balmana J, Dominguez-Garrido E, Ligtenberg M, Fewings E, Fitzgerald R, Woodward E, Evans G, Hanson H, Lagerstedt-Robinson K, Bajalica-Lagercrantz S, Teixeira M, Hoogerbrugge N, Tischkowitz M, Oliveira C

European Landscape of CDH1 germline mutations: a new tool to understand hereditary diffuse gastric cancer (HDGC) European journal of human genetics : EJHG 27: 1126-1128, 2019. [Meeting Abstract]

3.7

16. Barbosa-Matos R, Ferro A, Oliveira P, Mesquita B, Andre A, Pinheiro H, Carvalho J, Senz J, Kaurah P, Bordeira-Carrico R, Bessa J, Huntsman D, Oliveira C

Structural variations at CDH1 intronic cis-regulatory elements cause CDH1/E-cadherin loss of function European journal of human genetics : EJHG 27: 1131-1132, 2019. [Meeting Abstract]

3.7

17. Lopes-De-Almeida M, Garrido L, Oliveira JP, Castedo S, Oliveira C

The role of medical geneticists in the integrated care offered to patients with hereditary cancer syndromes Medicine 98: 26, 2019. [Meeting Abstract]

1.6

18. Garrido L, Nercio T, Leal R, Guimaraes R, Ferro L, Vilarinho L, Costa S, Magalhaes A, Mesquita AS, Pereira AF, Gullo I, Pinheiro H, Sousa S, Carvalho B, Neto AP, Capela L, Teixeira C, Fareleira A, Devezas V, Macedo G, Preto J, Barbosa J, Baptista M, Pinto G, Damasceno M, Fougo JL, Costa-Maia J, Fernandes S, Carneiro F, Castedo S, Oliveira C

Genetic counselling in hereditary diffuse gastric cancer: economical and psycho-social impact European journal of human genetics : EJHG 27: 864-864, 2019. [Meeting Abstract]

3.7

19. Korsak B, Almeida GM, Rocha S, Pereira C, Mendes N, Osório H, Pereira PMR, Rodrigues JMM, Schneider RJ, Sarmento B, Tomé JPC, Oliveira C

Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer. International journal of cancer 141: 1478-1489, 2017. [Article]

doi: 10.1002/ijc.30844 PMID: 28639285.

7.4

20. Oliveira P, Carvalho J, Rocha S, Azevedo M, Reis I, Camilo V, Sousa B, Valente S, Paredes J, Almeida R, Huntsman D, Oliveira C

Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation. Scientific reports 6: 34860, 2016. [Article]

doi: 10.1038/srep34860 PMID: 27721458.

4.3

21. Queirós P, Pinheiro H, Carvalho J, Oliveira P, Gullo I, Carneiro F, Almeida GM, Oliveira C

KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity. Virchows Archiv : an international journal of pathology 467: 383-92, 2015. [Article]

doi: 10.1007/s00428-015-1823-7 PMID: 26318594.

2.6

22. Pinheiro H, Oliveira P, Oliveira C

Hereditary cancer risk assessment: challenges for the next-gen sequencing era. Frontiers in oncology 5: 62, 2015. [Editorial Material]

doi: 10.3389/fonc.2015.00062 PMID: 25853090.

23. Carvalho J, Oliveira C

Extracellular Vesicles - Powerful Markers of Cancer EVolution. Frontiers in immunology 5: 685, 2014. [Editorial Material]

doi: 10.3389/fimmu.2014.00685 PMID: 25628624.

0.0

24. Bordeira-Carriço R, Ferreira D, Mateus DD, Pinheiro H, Pêgo AP, Santos MA, Oliveira C

Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA. European journal of human genetics : EJHG 22: 1085-92, 2014. [Article]

doi: 10.1038/ejhg.2013.292 PMID: 24424122.

4.3

25. Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C

Somatic mutations and deletions of the e-cadherin gene predict poor survival of patients with gastric cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31: 868-75, 2013. [Article]

doi: 10.1200/JCO.2012.44.4612 PMID: 23341533.

100

17.9

26. Carvalho J, van Grieken NC, Pereira PM, Sousa S, Tijssen M, Buffart TE, Diosdado B, Grabsch H, Santos MA, Meijer G, Seruca R, Carvalho B, Oliveira C

Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer. The Journal of pathology 228: 31-44, 2012. [Article]

doi: 10.1002/path.4032 PMID: 22450781.

7.6

27. Pinho SS, Oliveira P, Cabral J, Carvalho S, Huntsman D, Gärtner F, Seruca R, Reis CA, Oliveira C

Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions. PloS one 7: e33191, 2012. [Article]

doi: 10.1371/journal.pone.0033191 PMID: 22427986.

3.7

28. Bordeira-Carriço R, Pêgo AP, Santos M, Oliveira C

Cancer syndromes and therapy by stop-codon readthrough. Trends in molecular medicine 18: 667-78, 2012. [Review]

doi: 10.1016/j.molmed.2012.09.004 PMID: 23044248.

9.6

29. Pinheiro H, Carvalho J, Oliveira P, Ferreira D, Pinto MT, Osório H, Licastro D, Bordeira-Carriço R, Jordan P, Lazarevic D, Sanges R, Stupka E, Huntsman D, Seruca R, Oliveira C

Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesis. Human molecular genetics 21: 4253-69, 2012. [Article]

doi: 10.1093/hmg/dds248 PMID: 22752307.

7.7

30. Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, Dwerryhouse S, Caldas C, Linkage Consortium International Gastric Cancer

Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. Journal of medical genetics 47: 436-44, 2010. [Article]

doi: 10.1136/jmg.2009.074237 PMID: 20591882.

329

7.0

31. Pinheiro H, Bordeira-Carriço R, Seixas S, Carvalho J, Senz J, Oliveira P, Inácio P, Gusmão L, Rocha J, Huntsman D, Seruca R, Oliveira C

Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. Human molecular genetics 19: 943-52, 2010. [Article]

doi: 10.1093/hmg/ddp537. PMID: 19965908.

8.1

32. Karam R, Carvalho J, Bruno I, Graziadio C, Senz J, Huntsman D, Carneiro F, Seruca R, Wilkinson MF, Oliveira C

The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. Oncogene 27: 4255-60, 2008. [Article]

doi: 10.1038/onc.2008.62 PMID: 18427545.

7.2

33. Sobrinho-Simões M, Oliveira C

Different types of epithelial cadherin alterations play different roles in human carcinogenesis. Advances in anatomic pathology 9: 329-37, 2002. [Article]

PMID: 12409641.

1.8

@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto