Ana Ribeiro
Name: Ana Ribeiro
Academic Degree: PhD

Ana Ribeiro
Ana Ribeiro
Member of
Assistant Researcher of Cancer Metastasis

Short CV

ASR is a dynamic breast cancer (BC) researcher with a mission to uncover new biomarkers and therapies for metastatic breast cancer (BC). Her extensive training in the Netherlands, Sweden, and Portugal has finely tuned her scientific and technical expertise, amplifying her collaborative capacity.

Since 2017, ASR's long-term goal is to discover novel secreted BC biomarkers, a pivotal step in advancing innovative treatments for metastatic BC. For that, she has ventured into emerging disciplines, cutting-edge technologies and developed novel disease-relevant models. She has been particularly focused on BC brain metastasis and, in this context, she has developed a novel in vivo tool to study cancer stem cells and defined a brain BC stem cell signature that significantly predicts a worse prognosis for BC patients. ASR have also been developing 2D and 3D in vitro assays, ex-vivo organotypic cultures and several in vivo tools (e.g. chicken choriallantoic and mice) to overcome the lack of metastasis experimental models. Of relevance, her data has been crucial to attract funding in competitive calls for several projects where ASR has been involved in the coordination and supervision as PI, co-PI and task leader to advance on cancer metastasis, totaling >500K€, as well as for 5 projects (>3M€) where I she integrates as a team member.

ASR's entrepreneurial spirit has been recognized through the research grant (Hologic 2023) and by two innovation prizes (BIP Acceleration 2023, LPCC Innovation 2021), underscoring her unwavering dedication to advancing cancer metastasis research.

Her publication list includes 37 peer-reviewed papers (5 first and 1 last author) in Q1 journals (Oncogene, Hum Mol Gen, Lancet Oncol, Sem Can Biol, Nanoscale, J Pathol) and 4 book chapters, with a cumulative IF of 244.98, >1350 citations and h-index 19. 

Her journey is marked by innovation, collaboration, and an unshakable commitment to making a tangible difference in the lives of cancer patients worldwide.

Currently, our main interests are the molecular and signalling mechanism, involved in cancer cell invasion and metastization that are activated by cell-cell adhesion molecules (E- and P-cadherin).
Also, in order to understand P-cadherin functional and clinical relevance, we aim to get knowledge on its tissue specificity and functionality in both normal epithelial tissues and tumours.
Our work, will reinforced the importance of P-cadherin expression as a prognostic factor for breast cancer patients, supporting the development of new therapeutics to control aggressive carcinomas that express this epithelial cadherin.

Supervisor of
Francisca Moreira, Research Trainee
Inês Ribeiro, Research Trainee
Research Trainee
Rita Couto, Master Student (thesis)
MSc student

PI (running)

PI (closed)
First Author
1. Ribeiro AS, Nobre AR, Mendes N, Almeida J, Vieira AF, Sousa B, Carvalho FA, Monteiro J, Polónia A, Fonseca M, Sanches JM, Santos NC, Seruca R, Paredes J
SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells. Cell communication and signaling : CCS 16: 75, 2018. [Article] 
2. Ribeiro AS, Carvalho FA, Figueiredo J, Carvalho R, Mestre T, Monteiro J, Guedes AF, Fonseca M, Sanches J, Seruca R, Santos NC, Paredes J
 doi: 10.1039/c6nr04465d PMID: 27847941.
4. Ribeiro AS, Sousa B, Carreto L, Mendes N, Nobre AR, Ricardo S, Albergaria A, Cameselle-Teijeiro JF, Gerhard R, Söderberg O, Seruca R, Santos MA, Schmitt F, Paredes J
 doi: 10.1002/path.4143 PMID: 23180380.
5. Ribeiro AS, Albergaria A, Sousa B, Correia AL, Bracke M, Seruca R, Schmitt FC, Paredes J
Senior Author
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