RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH
 
Fernando Schmitt
Name: Fernando Schmitt
E-mail: fschmitt@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


Fernando Schmitt
Fernando Schmitt
Member of
Coordinator Researcher of Epithelial Interactions in Cancer
External Consultant of Ipatimup Diagnostics
External Researcher of Epithelial Interactions in Cancer


Short CV
Dr. Schmitt is a Professor of Pathology at the Medical Faculty of University of Porto and leads the Pathology Unit at Ipatimup.
Dr. Schmitt has authored more than 373 papers in peer-review journal and 23 book chapters; Fernando is widely considered a world-leading expert in cytopathology and breast cancer. Fernando was a fellow at the Karolinska Medical Hospital, Stockholm, and a Professor at Medical Faculty of UNESP, Brazil. At the Ipatimup he’s been responsible for important work on breast pathology, with emphasis on molecular markers, cell adhesion and invasion, as well as on therapeutic targets and mechanisms of resistance. Under his guidance, the Unit of Pathology became the only anatomic pathology lab accredited by CAP in the Iberian Peninsula. Fernando serves as Associate Editor of three major scientific journals and sits on the editorial board of many others. He has also been chairman, president or scientific director of several major European, Portuguese and Brazilian scientific societies. Currently he is Secretary-General of the International Academy of Cytology (IAC). Fernando was recently named Educator of the Year 2011 by the Papanicoloau Society of Cytology (USA).During the last few years Fernando has led five collaborative scientific projects

Highlights
Molecular Pathology of Breast Cancer; Molecular Cytopathology; Therapeutic Targets

Supervisor of
Catarina Costa, Research Trainee
Gabriella Ivády-Szabó, Research Trainee

PI (running)

PI (closed)
"Telepathological Assessment of histopathological and cytological techniques"
"Integrated Micro-Nano-OPTO Fluidic systems for high-content diagnosis and studies of rare cancer cells"
"mTOR expression in breast carcinomas and the ability of everolimus (RAD 001) to modulate its expression"
"Vitamin D, a candidate for new therapy of basal-like breast carcinomas"
"Pilot Project"
"Seminar"
"Trainning"
Approaching basal-like breast carcinomas to target theraphy. A project combining the reinforcement of logistics facilities with translational research
P-cadherin Expression: its effect in breast cancer metastasis and angiogenesis using in vivo animal models
"Vitamina D como terapia dos carcinomas mamários de tipo basal: ficção ou realidade?"
P53 e Resistência a Quimoterapia no Cancro da Mama
"P-cadherin in Breast Cancer: what regulates its expression and how it can induce invasion of neoplastic cells?"
"MAbEXPRESS"
First Author
 
C
IF
1. Schmitt FC
Lymph Node FNC - Cytopathology of Lymph Nodes and Extranodal Lymphoproliferative Processes Acta cytologica 62: 155-155, 2018. [Book Review] 
 doi: 10.1159/000487449.
 
0
1.6 (*)
2. Schmitt F, Barroca H
Role of ancillary studies in fine-needle aspiration from selected tumors. Cancer cytopathology 120: 145-60, 2012. [Review] 
 doi: 10.1002/cncy.20197 PMID: 22045615.
 
30
4.4
3. Schmitt F, Ricardo S, Vieira AF, Dionísio MR, Paredes J
Cancer stem cell markers in breast neoplasias: their relevance and distribution in distinct molecular subtypes. Virchows Archiv : an international journal of pathology 460: 545-53, 2012. [Review] 
 doi: 10.1007/s00428-012-1237-8 PMID: 22562130.
 
16
2.7
4. Schmitt F, Vielh P, Zeppa P
Cytology for pathologists: two sides of the same coin or different views of the same side? Cytopathology : official journal of the British Society for Clinical Cytology 23: 345-6, 2012. [Letter] 
 doi: 10.1111/cyt.12018 PMID: 22985228.
 
1
1.7
5. Schmitt FC
Molecular cytopathology and flow cytometry: pre-analytical procedures matter. Cytopathology : official journal of the British Society for Clinical Cytology 22: 1, 2011. [Editorial Material] 
 doi: 10.1111/j.1365-2303.2011.00941.x PMID: 22085281.
 
11
1.6
6. Schmitt F, Cochand-Priollet B, Toetsch M, Davidson B, Bondi A, Vielh P
Immunocytochemistry in Europe: results of the European Federation of Cytology Societies (EFCS) inquiry. Cytopathology : official journal of the British Society for Clinical Cytology 22: 238-42, 2011. [Article] 
 doi: 10.1111/j.1365-2303.2011.00885.x PMID: 21771093.
 
10
1.6
7. Schmitt F, Tötsch M, Vielh P
A letter yet to receive a reply. Cytopathology : official journal of the British Society for Clinical Cytology 22: 68-9, 2011. [Letter] 
 doi: 10.1111/j.1365-2303.2010.00839.x PMID: 21219487.
 
2
1.6
8. Schmitt FC, Longatto-Filho A, Valent A, Vielh P
Molecular techniques in cytopathology practice. Journal of clinical pathology 61: 258-67, 2008. [Article] 
 doi: 10.1136/jcp.2006.044347 PMID: 18037664.
 
59
2.3
9. Schmitt FC, Gomes AL, Milanezi F, Reis R, Bardales RH
Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration. Minerva medica 98: 385-8, 2007. [] 
 PMID: 17921955.
 
0
-
10. Schmitt FC
Thyroid cytology: FNA is still the best diagnostic approach. Cytopathology : official journal of the British Society for Clinical Cytology 17: 211-2, 2006. [Letter] 
 doi: 10.1111/j.1365-2303.2006.00353.x PMID: 16879271.
 
11
1.0
11. Schmitt FC, Reis-Filho JS
c-myc, not her-2/neu, can predict the prognosis of breast cancer patients: how novel, how accurate, and how significant? Breast cancer research : BCR 5: 188-91, 2003. [Review] 
 doi: 10.1186/bcr606 PMID: 12817989.
 
6
2.9
12. Schmitt FC, Reis-Filho JS
Oncogenes, granules and breast cancer: what has c-myc to do with apocrine changes? Breast (Edinburgh, Scotland) 11: 463-5, 2002. [Editorial Material] 
 doi: 10.1054/brst.2002.0480 PMID: 14965710.
 
6
0.5
13. Schmitt FC, Ribeiro CA, Alvarenga S, Lopes JM
Primary acinic cell-like carcinoma of the breast--a variant with good prognosis? Histopathology 36: 286-9, 2000. [Letter] 
 PMID: 10809602.
 
26
2.6
14. Schmitt F, Tani E
Cytological findings in cystic hypersecretory ductal carcinoma of the breast: a potential pitfall in mammary cytology. Cytopathology : official journal of the British Society for Clinical Cytology 11: 513-9, 2000. [Article] 
 PMID: 11194083.
 
8
0.8
15. Schmitt FC, Dias AJ, Wagner R
Use of ThinPrep processing for studying breast cancer cell lines. Diagnostic cytopathology 23: 27-8, 2000. [Letter] 
 doi: 10.1002/1097-0339(200007)23:1<27::AID-DC6>3.0.CO;2-D PMID: 10907928.
 
4
0.9
16. Schmitt F, Tani E
Fine-needle aspiration of idiopathic cystic chondromalacia (pseudocyst of the auricle): report of two cases. Diagnostic cytopathology 23: 214-5, 2000. [Letter] 
 PMID: 10945913.
 
1
0.9
17. Schmitt FC, Soares R, Gobbi H, Milanezzi F, Santos-Silva F, Cirnes L, Costa C, Seruca R
Microsatellite instability in medullary breast carcinomas. International journal of cancer 82: 644-7, 1999. [Article] 
 PMID: 10417760.
 
22
3.5
18. Schmitt F, Tani E, Tribukait B, Skoog L
Assessment of cell proliferation by Ki-67 staining and flow cytometry in fine needle aspirates (FNAs) of reactive lymphadenitis and non-Hodgkin's lymphomas. Cytopathology : official journal of the British Society for Clinical Cytology 10: 87-96, 1999. [Article] 
 PMID: 10211614.
 
16
0.7
19. Schmitt FC, Soares R
TGF-alpha and angiogenesis. The American journal of surgical pathology 23: 358-9, 1999. [Letter] 
 PMID: 10078932.
 
13
3.9
20. Schmitt FC, Pereira MB, Reis CA
MUC 5 expression in breast carcinomas. Human pathology 30: 1270-1, 1999. [Letter] 
 PMID: 10534181.
 
1
2.8
21. Schmitt F
Marcadores prognósticos em carcinoma mamário. Manual de Imuno-histoquímica 1: 30-46, 1999. [] 
.
 
0
-
22. Schmitt FC, AC Mera A
Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies. Acta cytologica 42: 721-4, 1998. [Article] 
 PMID: 9622694.
 
21
-
23. Schmitt FC, Soares R, Cirnes L, Seruca R
P53 in breast carcinomas: association between presence of mutation and immunohistochemical expression using a semiquantitative approach. Pathology, research and practice 194: 815-9, 1998. [Article] 
 PMID: 9894246.
 
16
-
24. Schmitt FC, Soares R, Cirnes L, Seruca R
PCR amplification of DNA obtained from archived hematoxylin-eosin--and giemsa-stained breast cancer aspirates. Diagnostic cytopathology 19: 395-7, 1998. [Article] 
 doi: 10.1002/(SICI)1097-0339(199811)19:5<395::AID-DC19>3.0.CO;2-4 PMID: 9812239.
 
11
-
25. Schmitt FC, Soares R, Leitão D
Detection of numerical chromosome 17 abnormalities in fine-needle aspirates of breast cancer using a novel in situ hybridization signal amplification method. Diagnostic cytopathology 19: 141-6, 1998. [Article] 
 PMID: 9702495.
 
7
-
26. Schmitt FC, Soares R, Seruca R
Bilateral apocrine carcinoma of the breast. Molecular and immunocytochemical evidence for two independent primary tumours. Virchows Archiv : an international journal of pathology 433: 505-9, 1998. [Article] 
 PMID: 9870682.
 
7
-
27. Schmitt FC, Marinho A, Amendoeira I
Expression of sialyl-Tn in fine-needle aspirates from mammographically detected breast lesions: a marker of malignancy? Diagnostic cytopathology 18: 325-9, 1998. [Article] 
 PMID: 9582565.
 
6
-
28. Schmitt FC, Bento MJ, Amendoeira I
Estimation of estrogen receptor content in fine-needle aspirates from breast cancer using the monoclonal antibody 1D5 and microwave oven processing: correlation with paraffin embedded and frozen sections determinations. Diagnostic cytopathology 13: 347-51, 1995. [Note] 
 PMID: 8599924.
 
33
-
29. Schmitt FC, Figueiredo P, Lacerda M
Expression of c-erb B-2 protein and DNA ploidy in breast carcinogenesis. Archives of pathology & laboratory medicine 119: 815-20, 1995. [Article] 
 PMID: 7668939.
 
22
-
Senior Author
 
C
IF
1. Canberk S, Montezuma D, Aydin O, Demirhas MP, Denizci B, Akbas M, Caliskan C, Tokat F, Ince U, Schmitt F
The new guidelines of Papanicolaou Society of Cytopathology for respiratory specimens: Assessment of risk of malignancy and diagnostic yield in different cytological modalities. Diagnostic cytopathology 46: 725-729, 2018. [Article] 
 doi: 10.1002/dc.24036 PMID: 30051969.
 
0
1.0 (*)
2. Vieira AF, Schmitt F
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers. Frontiers in medicine 5: 248, 2018. [Review] 
 doi: 10.3389/fmed.2018.00248 PMID: 30234119.
 
0
-
3. Montezuma D, Canberk S, Aydin O, Dermirhas MP, Vieira AF, Goksel S, Ince Ü, Schmitt F
A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different? Diagnostic cytopathology 46: 859-863, 2018. [Article] 
 doi: 10.1002/dc.24037 PMID: 30369104.
 
0
1.0 (*)
4. Malheiros DC, Canberk S, Poller DN, Schmitt F
Thyroid FNAC: Causes of false-positive results. Cytopathology : official journal of the British Society for Clinical Cytology 29: 407-417, 2018. [Review] 
 doi: 10.1111/cyt.12575 PMID: 29768677.
 
0
1.4 (*)
5. Martins D, Schmitt F
Microenvironment in breast tumorigenesis: Friend or foe? Histology and histopathology  , 2018. [Review - 18021; Epub ahead of print] 
 doi: 10.14670/HH-18-021 PMID: 29978449.
 
0
2.0 (*)
6. Schmitt FC
Lymph Node FNC - Cytopathology of Lymph Nodes and Extranodal Lymphoproliferative Processes Acta cytologica 62: 155-155, 2018. [Book Review] 
 doi: 10.1159/000487449.
 
0
1.6 (*)
7. Rossi ED, Bizzarro T, Longatto-Filho A, Gerhard R, Schmitt F
The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance? Expert review of anticancer therapy 15: 911-21, 2015. [Review] 
 doi: 10.1586/14737140.2015.1053874 PMID: 26204907.
 
8
2.1
8. Beca F, Pereira M, Cameselle-Teijeiro JF, Martins D, Schmitt F
Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer. BMC cancer 15: 285, 2015. [Article] 
 doi: 10.1186/s12885-015-1266-1 PMID: 25879784.
 
7
3.3
9. Diana Rossi E, Martini M, Straccia P, Gerhard R, Evangelista A, Pontecorvi A, Fadda G, Maria Larocca L, Schmitt F
Is thyroid gland only a "land" for primary malignancies? role of morphology and immunocytochemistry. Diagnostic cytopathology 43: 374-80, 2015. [Article] 
 doi: 10.1002/dc.23241 PMID: 25427948.
 
5
1.0
10. Canberk S, Firat P, Schmitt F
Pitfalls in the Cytological Assessment of Thyroid Nodules. Tu¨rk patoloji dergisi 31 Suppl 1: 18-33, 2015. [Article] 
 doi: 10.5146/tjpath.2015.01312 PMID: 26177315.
 
0
-
11. Rossi ED, Bizzarro T, Martini M, Capodimonti S, Fadda G, Larocca LM, Schmitt F
Morphological parameters able to predict BRAF(V600E) -mutated malignancies on thyroid fine-needle aspiration cytology: Our institutional experience. Cancer cytopathology 122: 883-91, 2014. [Article] 
 doi: 10.1002/cncy.21475 PMID: 25156883.
 
20
3.4
12. Rossi ED, Bizzarro T, Fadda G, Larocca LM, Schmitt F
Is morphology alone able to predict BRAF-mutated malignancies on thyroid FNAC? Virchows Archiv : an international journal of pathology 465: 247-8, 2014. [Letter] 
 doi: 10.1007/s00428-014-1607-5 PMID: 24928715.
 
11
2.7
13. Almeida D, Gerhard R, Leitão D, Davilla C, Damasceno M, Schmitt F
Topoisomerase II-alfa gene as a predictive marker of response to anthracyclines in breast cancer. Pathology, research and practice 210: 675-9, 2014. [Article] 
 doi: 10.1016/j.prp.2014.06.017 PMID: 25042383.
 
9
1.4
14. Beca F, Andre R, Martins DS, Bilhim T, Martins D, Schmitt F
p-mTOR expression is associated with better prognosis in luminal breast carcinoma. Journal of clinical pathology 67: 961-7, 2014. [Article] 
 doi: 10.1136/jclinpath-2014-202320 PMID: 25053543.
 
8
2.9
15. Beca F, Santos R, Vieira D, Zeferino L, Dufloth R, Schmitt F
Primary relapse site pattern in women with triple-negative breast cancer. Pathology, research and practice 210: 571-5, 2014. [Article] 
 doi: 10.1016/j.prp.2014.05.011 PMID: 24939141.
 
7
1.4
16. Beca F, Schmitt F
Growing indication for FNA to study and analyze tumor heterogeneity at metastatic sites. Cancer cytopathology 122: 504-11, 2014. [Review] 
 doi: 10.1002/cncy.21395 PMID: 24478259.
 
7
3.4
17. Martins D, Beca F, Schmitt F
Metastatic breast cancer: mechanisms and opportunities for cytology. Cytopathology : official journal of the British Society for Clinical Cytology 25: 225-30, 2014. [Review] 
 doi: 10.1111/cyt.12158 PMID: 24889678.
 
6
1.5
18. Pereira BD, Gerhard R, Schmitt F
Putting an eye on cytological specimens: an audit of the clinical impact of thyroid fine-needle aspiration in different health care settings. Diagnostic cytopathology 42: 1009-12, 2014. [Article] 
 doi: 10.1002/dc.23153 PMID: 24678022.
 
1
1.1
19. Ferreira MA, Gerhard R, Schmitt F
Analysis of nondiagnostic results in a large series of thyroid fine-needle aspiration cytology performed over 9 years in a single center. Acta cytologica 58: 229-34, 2014. [] 
 doi: 10.1159/000360066 PMID: 24662526.
 
0
1.6 (*)
20. Rossi ED, Gerhard R, Cirnes L, Machado JC, Schmitt F
Detection of common and less frequent EGFR mutations in cytological samples of lung cancer. Acta cytologica 58: 275-80, 2014. [] 
 doi: 10.1159/000363174 PMID: 24924582.
 
0
1.6 (*)
21. Di Lorito A, Zappacosta R, Capanna S, Gatta DM, Rosini S, Schmitt FC
Expression of PTEN in Endometrial Liquid-Based Cytology. Acta cytologica 58: 495-500, 2014. [] 
 doi: 10.1159/000367961 PMID: 25358681.
 
0
1.6 (*)
22. Rossi ED, Fadda G, Schmitt F
The Nightmare of Indeterminate Follicular Proliferations: When Liquid-Based Cytology and Ancillary Techniques are not a Moon Landing but a Realistic Plan. Acta cytologica 58: 543-51, 2014. [] 
 doi: 10.1159/000363439 PMID: 25033918.
 
0
1.6 (*)
23. Beça FF, Caetano P, Gerhard R, Alvarenga CA, Gomes M, Paredes J, Schmitt F
Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types. Journal of clinical pathology 66: 187-91, 2013. [Article] 
 doi: 10.1136/jclinpath-2012-201169 PMID: 23112116.
 
62
2.6
24. Nobre AR, Albergaria A, Schmitt F
p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta cytologica 57: 1-8, 2013. [Review] 
 doi: 10.1159/000345245 PMID: 23221041.
 
35
1.6
25. Martins D, Beça FF, Sousa B, Baltazar F, Paredes J, Schmitt F
Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma: Key events in the progression from an in situ to an invasive breast carcinoma. Cell cycle (Georgetown, Tex.) 12: 2684-90, 2013. [Article] 
 doi: 10.4161/cc.25794 PMID: 23907124.
 
22
5.0
26. Gerhard R, Carvalho A, Carneiro V, Bento RS, Uemura G, Gomes M, Albergaria A, Schmitt F
Clinicopathological significance of ERCC1 expression in breast cancer. Pathology, research and practice 209: 331-6, 2013. [Article] 
 doi: 10.1016/j.prp.2013.02.009 PMID: 23702380.
 
10
1.6
27. Albergaria A, Resende C, Nobre AR, Ribeiro AS, Sousa B, Machado JC, Seruca R, Paredes J, Schmitt F
CCAAT/enhancer binding protein ß (C/EBPß) isoforms as transcriptional regulators of the pro-invasive CDH3/P-cadherin gene in human breast cancer cells. PloS one 8: e55749, 2013. [Article] 
 doi: 10.1371/journal.pone.0055749 PMID: 23405208.
 
6
3.5
28. Gerhard R, Teixeira S, Gaspar da Rocha A, Schmitt F
Thyroid fine-needle aspiration cytology: Is there a place to virtual cytology? Diagnostic cytopathology 41: 793-8, 2013. [Article] 
 doi: 10.1002/dc.22958 PMID: 23441010.
 
3
1.5
29. Di Lorito A, Rosini S, Falò E, Gustapane S, Gomes M, Costa JL, Schmitt FC
Molecular alterations in endometrial archived liquid-based cytology. Diagnostic cytopathology 41: 492-6, 2013. [Article] 
 doi: 10.1002/dc.22869 PMID: 22807394.
 
3
1.5
30. Lopes N, Paredes J, Costa JL, Ylstra B, Schmitt F
Vitamin D and the mammary gland: a review on its role in normal development and breast cancer. Breast cancer research : BCR 14: 211, 2012. [Review] 
 doi: 10.1186/bcr3178 PMID: 22676419.
 
23
5.9
31. Gerhard R, Ricardo S, Albergaria A, Gomes M, Silva AR, Logullo AF, Cameselle-Teijeiro JF, Paredes J, Schmitt F
Immunohistochemical features of claudin-low intrinsic subtype in metaplastic breast carcinomas. Breast (Edinburgh, Scotland) 21: 354-60, 2012. [Article] 
 doi: 10.1016/j.breast.2012.03.001 PMID: 22464177.
 
23
2.5 (*)
32. Alvarenga CA, Paravidino PI, Alvarenga M, Gomes M, Dufloth R, Zeferino LC, Vassallo J, Schmitt FC
Reappraisal of immunohistochemical profiling of special histological types of breast carcinomas: a study of 121 cases of eight different subtypes. Journal of clinical pathology 65: 1066-71, 2012. [Article] 
 doi: 10.1136/jclinpath-2012-200885 PMID: 22944625.
 
7
2.4
33. Di Lorito A, Schmitt FC
(Cyto)pathology and sequencing: Next (or last) generation? Diagnostic cytopathology 40: 459-61, 2012. [Article] 
 doi: 10.1002/dc.21691 PMID: 21538954.
 
7
1.5
34. Gerhard R, Costa JL, Schmitt F
Benign and malignant apocrine lesions of the breast. Expert review of anticancer therapy 12: 215-21, 2012. [Review] 
 doi: 10.1586/era.11.213 PMID: 22316369.
 
5
2.1
35. Faria G, Cardoso MJ, Martins D, Bettencourt H, Amendoeira I, Schmitt F
P-cadherin as prognostic factor for loco-regional relapse in breast cancer. Acta medica portuguesa 25: 97-105, 2012. [Article] 
 PMID: 22985920.
 
2
0.2
36. Gama A, Schmitt F
Cadherin cell adhesion system in canine mammary cancer: a review. Veterinary medicine international 2012: 357187, 2012. [] 
 doi: 10.1155/2012/357187 PMID: 22973534.
 
0
-
37. Albergaria A, Ricardo S, Milanezi F, Carneiro V, Amendoeira I, Vieira D, Cameselle-Teijeiro J, Schmitt F
Nottingham Prognostic Index in Triple-Negative Breast Cancer: a reliable prognostic tool? BMC cancer 11: 299, 2011. [Article] 
 doi: 10.1186/1471-2407-11-299 PMID: 21762477.
 
26
3.0
38. Alvarenga CA, Paravidino PI, Alvarenga M, Dufloth R, Gomes M, Zeferino LC, Schmitt F
Expression of CK19 in invasive breast carcinomas of special histological types: implications for the use of one-step nucleic acid amplification. Journal of clinical pathology 64: 493-7, 2011. [Article] 
 doi: 10.1136/jcp.2011.089862 PMID: 21427448.
 
22
2.3
39. Schmitt FC
Molecular cytopathology and flow cytometry: pre-analytical procedures matter. Cytopathology : official journal of the British Society for Clinical Cytology 22: 1, 2011. [Editorial Material] 
 doi: 10.1111/j.1365-2303.2011.00941.x PMID: 22085281.
 
11
1.6
40. Martins D, Sousa B, Lopes N, Gomes M, Veronese L, Albergaria A, Paredes J, Schmitt F
Molecular phenotypes of matched in situ and invasive components of breast carcinomas. Human pathology 42: 1438-46, 2011. [Article] 
 doi: 10.1016/j.humpath.2010.08.024 PMID: 21450330.
 
6
2.9
41. Lopes N, Sousa B, Martins D, Gomes M, Vieira D, Veronese LA, Milanezi F, Paredes J, Costa JL, Schmitt F
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions. BMC cancer 10: 483, 2010. [Article] 
 doi: 10.1186/1471-2407-10-483 PMID: 20831823.
 
101
3.2
42. Sousa B, Paredes J, Milanezi F, Lopes N, Martins D, Dufloth R, Vieira D, Albergaria A, Veronese L, Carneiro V, Carvalho S, Costa JL, Zeferino L, Schmitt F
P-cadherin, vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study. Histology and histopathology 25: 963-74, 2010. [Article] 
 PMID: 20552547.
 
35
2.5
43. Carvalho S, Milanezi F, Costa JL, Amendoeira I, Schmitt F
PIKing the right isoform: the emergent role of the p110beta subunit in breast cancer. Virchows Archiv : an international journal of pathology 456: 235-43, 2010. [Article] 
 doi: 10.1007/s00428-010-0881-0 PMID: 20130907.
 
29
2.3
44. Gama A, Alves A, Schmitt F
Expression and prognostic significance of CK19 in canine malignant mammary tumours. Veterinary journal (London, England : 1997) 184: 45-51, 2010. [Article] 
 doi: 10.1016/j.tvjl.2009.02.001 PMID: 19264518.
 
12
2.8
45. Albergaria A, Ribeiro AS, Pinho S, Milanezi F, Carneiro V, Sousa B, Sousa S, Oliveira C, Machado JC, Seruca R, Paredes J, Schmitt F
ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBPbeta in CDH3 gene activation. Human molecular genetics 19: 2554-66, 2010. [Article] 
 doi: 10.1093/hmg/ddq134 PMID: 20385540.
 
10
8.1
46. Filho AL, Schmitt FC
Cytology education in the 21st century: living in the past or crossing the Rubicon? Acta cytologica 54: 654-6, 2010. [Letter] 
 PMID: 20715674.
 
9
0.6
47. Syrjänen K, Di Bonito L, Gonçalves L, Murjal L, Santamaria M, Mahovlic V, Karakitsos P, Onal B, Schmitt FC
Cervical cancer screening in Mediterranean countries: implications for the future. Cytopathology : official journal of the British Society for Clinical Cytology 21: 359-367, 2010. [Review] 
 doi: 10.1111/j.1365-2303.2010.00795.x PMID: 20718841.
 
9
1.1
48. Carvalho S, Schmitt F
Potential role of PI3K inhibitors in the treatment of breast cancer. Future oncology (London, England) 6: 1251-63, 2010. [Review] 
 doi: 10.2217/fon.10.97 PMID: 20799872.
 
8
2.5
49. Longatto Filho A, Lopes JM, Schmitt FC
Angiogenesis and breast cancer. Journal of oncology 2010: 576384, 2010. [] 
 doi: 10.1155/2010/576384 PMID: 20953378.
 
0
-
50. Albergaria A, Paredes J, Sousa B, Milanezi F, Carneiro V, Bastos J, Costa S, Vieira D, Lopes N, Lam EW, Lunet N, Schmitt F
Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast cancer research : BCR 11: 3, 2009. [Article] 
 PMID: 19549328.
 
85
5.3
51. Gama A, Gärtner F, Alves A, Schmitt F
Immunohistochemical expression of Epidermal Growth Factor Receptor (EGFR) in canine mammary tissues. Research in veterinary science 87: 432-7, 2009. [Article] 
 doi: 10.1016/j.rvsc.2009.04.016 PMID: 19464036.
 
44
1.3
52. Lopes N, Sousa B, Vieira D, Milanezi F, Schmitt F
Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles. Histopathology 55: 594-9, 2009. [Article] 
 doi: 10.1111/j.1365-2559.2009.03417.x PMID: 19912365.
 
14
3.9
53. Eloy C, Amendoeira I, Schmitt FC
Fine-needle aspiration as an alternative method for frozen tissue banking of breast cancer. Diagnostic cytopathology 37: 76-7, 2009. [Letter] 
 doi: 10.1002/dc.20958 PMID: 18973129.
 
9
1.3
54. Dufloth RM, Alves JM, Martins D, Vieira DS, Chikota H, Zeferino LC, Schmitt F
Cytological criteria to predict basal phenotype of breast carcinomas. Diagnostic cytopathology 37: 809-14, 2009. [Article] 
 doi: 10.1002/dc.21102 PMID: 19431201.
 
3
1.3
55. Polidoro AS, Dufloth RM, Vieira DSC, Zeferino LC, Schmitt F
Possible Relationship between Basal-Like Breast Carcinoma and Age Breast Care 4: 183-187, 2009. [Article] 
 doi: 10.1159/000220595.
 
1
0.5
56. Carvalho S, Milanezi F, Costa LJ, Schmitt F
Piking the right isoform for breast cancer progression Virchows Archiv : an international journal of pathology 455: 74-74, 2009. [Meeting Abstract] 
.
 
0
2.3
57. Gama A, Alves A, Schmitt F
Identification of molecular phenotypes in canine mammary carcinomas with clinical implications: application of the human classification. Virchows Archiv : an international journal of pathology 453: 123-32, 2008. [Article] 
 doi: 10.1007/s00428-008-0644-3 PMID: 18677512.
 
76
2.1
58. Costa S, Pinto D, Pereira D, Rodrigues H, Cameselle-Teijeiro J, Medeiros R, Schmitt F
Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer. BMC cancer 8: 32, 2008. [Article] 
 doi: 10.1186/1471-2407-8-32 PMID: 18230179.
 
70
3.1
59. Milanezi F, Carvalho S, Schmitt FC
EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy. Expert review of molecular diagnostics 8: 417-34, 2008. [Review] 
 doi: 10.1586/14737159.8.4.417 PMID: 18598224.
 
59
3.5
60. Kocjan G, Bourgain C, Fassina A, Hagmar B, Herbert A, Kapila K, Kardum-Skelin I, Kloboves-Prevodnik V, Krishnamurthy S, Koutselini H, Majak B, Olszewski W, Onal B, Pohar-Marinsek Z, Shabalova I, Smith J, Tani E, Vielh P, Wiener H, Schenck U, Schmitt F
The role of breast FNAC in diagnosis and clinical management: a survey of current practice. Cytopathology : official journal of the British Society for Clinical Cytology 19: 271-8, 2008. [Editorial Material] 
 doi: 10.1111/j.1365-2303.2008.00610.x PMID: 18821945.
 
53
1.5
61. Gama A, Paredes J, Gärtner F, Alves A, Schmitt F
Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival. Veterinary journal (London, England : 1997) 177: 45-53, 2008. [Article] 
 doi: 10.1016/j.tvjl.2007.05.024 PMID: 17631398.
 
41
1.8
62. Paredes J, Correia AL, Ribeiro AS, Milanezi F, Cameselle-Teijeiro J, Schmitt FC
Breast carcinomas that co-express E- and P-cadherin are associated with p120-catenin cytoplasmic localization and poor patient survival. Journal of clinical pathology 61: 856-62, 2008. [Article] 
 doi: 10.1136/jcp.2007.052704 PMID: 18381381.
 
38
2.3
63. Longatto-Filho A, Pinheiro C, Ferreira L, Scapulatempo C, Alves VA, Baltazar F, Schmitt F
Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Virchows Archiv : an international journal of pathology 452: 133-8, 2008. [Article] 
 doi: 10.1007/s00428-007-0550-0 PMID: 18087718.
 
18
2.1
64. Costa S, Pinto D, Pereira D, Rodrigues H, Cameselle-Teijeiro J, Medeiros R, Schmitt F
XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients. Breast cancer research and treatment 109: 183-5, 2008. [Letter] 
 doi: 10.1007/s10549-007-9637-1 PMID: 17616806.
 
14
5.7
65. Gama A, Alves A, Schmitt FC
Clinicopathologic features of mammary invasive micropapillary carcinoma (IMC) in dogs. Veterinary pathology 45: 600-1, 2008. [Letter] 
 doi: 10.1354/vp.45-4-600 PMID: 18587110.
 
8
1.4
66. Silva F, Carvalho S, Milanezi F, Schmitt FC
[Basal-like carcinoma of the breast] Acta medica portuguesa 21: 373-8, 2008. [Review] 
 PMID: 19094813.
 
4
-
67. Costa S, Pinto D, Pereira D, Rodrigues H, Cameselle-Teijeiro J, Medeiros R, Schmitt F
DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population. Breast cancer research and treatment 103: 209-17, 2007. [Article] 
 doi: 10.1007/s10549-006-9364-z PMID: 17063276.
 
73
4.5
68. Paredes J, Correia AL, Ribeiro AS, Albergaria A, Milanezi F, Schmitt FC
P-cadherin expression in breast cancer: a review. Breast cancer research : BCR 9: 214, 2007. [Review] 
 doi: 10.1186/bcr1774 PMID: 18001487.
 
67
4.4
69. Paredes J, Lopes N, Milanezi F, Schmitt FC
P-cadherin and cytokeratin 5: useful adjunct markers to distinguish basal-like ductal carcinomas in situ. Virchows Archiv : an international journal of pathology 450: 73-80, 2007. [Article] 
 doi: 10.1007/s00428-006-0334-y PMID: 17123107.
 
65
2.0
70. Gomes AL, Bardales RH, Milanezi F, Reis RM, Schmitt F
Molecular analysis of c-Kit and PDGFRA in GISTs diagnosed by EUS. American journal of clinical pathology 127: 89-96, 2007. [Article] 
 doi: 10.1309/M1EC8JE9ACAMJACU PMID: 17145623.
 
43
2.6
71. Longatto-Filho A, Pinheiro C, Pereira SM, Etlinger D, Moreira MA, Jubé LF, Queiroz GS, Baltazar F, Schmitt FC
Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Gynecologic oncology 107: 45-51, 2007. [Article] 
 doi: 10.1016/j.ygyno.2007.05.029 PMID: 17604828.
 
36
2.6
72. Ricardo SA, Milanezi F, Carvalho ST, Leitão DR, Schmitt FC
HER2 evaluation using the novel rabbit monoclonal antibody SP3 and CISH in tissue microarrays of invasive breast carcinomas. Journal of clinical pathology 60: 1001-5, 2007. [Article] 
 doi: 10.1136/jcp.2006.040287 PMID: 17158643.
 
31
2.4
73. Cassali GD, Gobbi H, Malm C, Schmitt FC
Evaluation of accuracy of fine needle aspiration cytology for diagnosis of canine mammary tumours: comparative features with human tumours. Cytopathology : official journal of the British Society for Clinical Cytology 18: 191-6, 2007. [Article] 
 doi: 10.1111/j.1365-2303.2007.00412.x PMID: 17573766.
 
24
1.2
74. Baltazar F, Filho AL, Pinheiro C, Moreira MA, Queiroz GS, Oton GJ, Júnior AF, Ribeiro LF, Schmitt FC
Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 26: 235-41, 2007. [Article] 
 doi: 10.1097/pgp.0b013e31802f1996 PMID: 17581404.
 
20
1.7
75. Paredes J, Correia AL, Ribeiro AS, Schmitt F
Expression of p120-catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines. Cellular oncology : the official journal of the International Society for Cellular Oncology 29: 467-76, 2007. [Article] 
 PMID: 18032823.
 
12
4.2
76. Longatto-Filho A, Schmitt FC
Gynecological cytology: too old to be a pop star but too young to die. Diagnostic cytopathology 35: 672-3, 2007. [Letter] 
 doi: 10.1002/dc.20700 PMID: 17854085.
 
11
1.0
77. Filho AL, Baltazar F, Bedrossian C, Michael C, Schmitt FC
Immunohistochemical expression and distribution of VEGFR-3 in malignant mesothelioma. Diagnostic cytopathology 35: 786-91, 2007. [Article] 
 doi: 10.1002/dc.20767 PMID: 18008346.
 
9
1.0
78. Schmitt FC
Cells carry the clue for targeted treatment: a new horizont for cytopathology. Cytopathology 18: 275-7, 2007. [Editorial Material] 
.
 
6
1.2
79. Longatto Filho A, Costa SM, Milanezi F, Montruccoli D, Montruccoli GC, Baltazar F, Schmitt FC
Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography. Oncology reports 18: 1201-6, 2007. [Article] 
 PMID: 17914573.
 
4
1.6
80. Schmitt FC
Is BRCA1 a possible predictor of response to neo-adjuvant chemotherapy ? Hereditary Cancer in Clinical Practice 5: 136-7, 2007. [] 
.
 
0
-
81. Reis-Filho JS, Milanezi F, Steele D, Savage K, Simpson PT, Nesland JM, Pereira EM, Lakhani SR, Schmitt FC
Metaplastic breast carcinomas are basal-like tumours. Histopathology 49: 10-21, 2006. [Article] 
 doi: 10.1111/j.1365-2559.2006.02467.x PMID: 16842242.
 
227
3.2
82. Reis-Filho JS, Pinheiro C, Lambros MB, Milanezi F, Carvalho S, Savage K, Simpson PT, Jones C, Swift S, Mackay A, Reis RM, Hornick JL, Pereira EM, Baltazar F, Fletcher CD, Ashworth A, Lakhani SR, Schmitt FC
EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. The Journal of pathology 209: 445-53, 2006. [Article] 
 doi: 10.1002/path.2004 PMID: 16739104.
 
157
5.8
83. Schmitt FC
Thyroid cytology: FNA is still the best diagnostic approach. Cytopathology : official journal of the British Society for Clinical Cytology 17: 211-2, 2006. [Letter] 
 doi: 10.1111/j.1365-2303.2006.00353.x PMID: 16879271.
 
11
1.0
84. Moreira MA, Longato-Filho A, Taromaru E, Queiroz G, Jubé LF, Pinto SA, Schmitt FC
Investigation of human papillomavirus by hybrid capture II in cervical carcinomas including 113 adenocarcinomas and related lesions. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 16: 586-90, 2006. [Article] 
 doi: 10.1111/j.1525-1438.2006.00374.x PMID: 16681730.
 
8
1.5
85. Utagawa ML, di Loreto C, de Freitas C, Milanezi F, Longatto Filho A, Pereira SM, Maeda MY, Schmitt FC
Pero Vaz de Caminha: an-interchange program for quality control between Brazil and Portugal. Acta cytologica 50: 303-8, 2006. [Article] 
 PMID: 16780025.
 
3
0.8
86. Cameselle-Teijeiro JF, Cortizo-Torres ME, Schmitt FC
[Medical chronobiology: inheritance and cancer]. Revista clínica española 206: 60-1; author reply 61, 2006. [Letter] 
 PMID: 16527055.
 
0
0.4
87. Matos I, Dufloth R, Alvarenga M, Zeferino LC, Schmitt F
p63, cytokeratin 5, and P-cadherin: three molecular markers to distinguish basal phenotype in breast carcinomas. Virchows Archiv : an international journal of pathology 447: 688-94, 2005. [Article] 
 doi: 10.1007/s00428-005-0010-7 PMID: 16012853.
 
174
2.2
88. Paredes J, Albergaria A, Oliveira JT, Jerónimo C, Milanezi F, Schmitt FC
P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clinical cancer research : an official journal of the American Association for Cancer Research 11: 5869-77, 2005. [Article] 
 doi: 10.1158/1078-0432.CCR-05-0059 PMID: 16115928.
 
135
5.7
89. Carvalho I, Milanezi F, Martins A, Reis RM, Schmitt F
Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast cancer research : BCR 7: R788-95, 2005. [Article] 
 doi: 10.1186/bcr1304 PMID: 16168125.
 
116
4.0
90. Reis-Filho JS, Milanezi F, Carvalho S, Simpson PT, Steele D, Savage K, Lambros MB, Pereira EM, Nesland JM, Lakhani SR, Schmitt FC
Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis. Breast cancer research : BCR 7: R1028-35, 2005. [Article] 
 doi: 10.1186/bcr1341 PMID: 16280056.
 
85
4.0
91. Longatto Filho A, Martins A, Costa SM, Schmitt FC
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels. Pathology, research and practice 201: 93-9, 2005. [Article] 
 PMID: 15901129.
 
13
1.0
92. Reis-Filho JS, de Landér Schmitt FC
Fluorescence in situ hybridization, comparative genomic hybridization, and other molecular biology techniques in the analysis of effusions. Diagnostic cytopathology 33: 294-9, 2005. [Article; Proceedings Paper] 
 doi: 10.1002/dc.20278 PMID: 16240394.
 
12
1.0
93. Longatto Filho A, Albergaria A, Paredes J, Moreira MA, Milanezi F, Schmitt FC
P-cadherin expression in glandular lesions of the uterine cervix detected by liquid-based cytology. Cytopathology : official journal of the British Society for Clinical Cytology 16: 88-93, 2005. [Article] 
 doi: 10.1111/j.1365-2303.2004.00226.x PMID: 15787651.
 
9
0.8
94. Granja Nde M, Ricardo SA, Longatto Filho A, Alves VA, Bedrossian CW, Wiley EL, Schmitt FC
Potential use of loss of heterozygosity in pleural effusions of breast cancer metastases using the microsatellite marker of the 16q22.1 region of the CDH1 gene. Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 27: 61-6, 2005. [Article] 
 PMID: 15913197.
 
4
0.6
95. Dufloth RM, Carvalho S, Heinrich JK, Shinzato JY, dos Santos CC, Zeferino LC, Schmitt F
Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with positive family history. São Paulo medical journal = Revista paulista de medicina 123: 192-7, 2005. [] 
 doi: /S1516-31802005000400007 PMID: 16389418.
 
0
-
96. Granja NM, Begnami MD, Bortolan J, Filho AL, Schmitt FC
Desmoplastic small round cell tumour: Cytological and immunocytochemical features. CytoJournal 2: 6, 2005. [] 
 doi: 10.1186/1742-6413-2-6 PMID: 15777480.
 
0
-
97. Soares R, Balogh G, Guo S, Gärtner F, Russo J, Schmitt F
Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Molecular endocrinology (Baltimore, Md.) 18: 2333-43, 2004. [Article] 
 doi: 10.1210/me.2003-0362 PMID: 15192074.
 
84
5.9
98. Paredes J, Stove C, Stove V, Milanezi F, Van Marck V, Derycke L, Mareel M, Bracke M, Schmitt F
P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. Cancer research 64: 8309-17, 2004. [Article] 
 doi: 10.1158/0008-5472.CAN-04-0795 PMID: 15548699.
 
51
7.7
99. Costa C, Soares R, Schmitt F
Angiogenesis: now and then. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 112: 402-12, 2004. [Review] 
 doi: 10.1111/j.1600-0463.2004.apm11207-0802.x PMID: 15563305.
 
45
1.5
100. Carvalho S, e Silva AO, Milanezi F, Ricardo S, Leitão D, Amendoeira I, Schmitt FC
c-KIT and PDGFRA in breast phyllodes tumours: overexpression without mutations? Journal of clinical pathology 57: 1075-9, 2004. [Article] 
 doi: 10.1136/jcp.2004.016378 PMID: 15452163.
 
36
2.6
@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
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