André Vieira
Name: André Vieira
E-mail: avieira@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


André Vieira
André Vieira
Member of


Short CV
André Vieira (Vieira AF) has a Biochemistry degree by the University of Porto, Portugal, having completed his Doctoral degree in 2012 on the topic of cancer stem cells (CSCs) and the tumour microenvironment (University of Porto, Portugal, in collaboration with the University of Manchester, UK).

His area of scientific specialization is the Biology and Genetics of breast cancer, with a particular focus in the role of adhesion molecules in CSCs, the cell-of-origin of breast tumours and the CSC niche, having authored and co-authored several original works and review articles in international peer-reviewed journals.
The role of the adhesion molecule P-cadherin in normal physiology is poorly understood and his current research interests are now focusing on P-cadherin as a regulator of normal epithelial cell polarity and stem cell division.

His main technical skills include stem cell biology assays, such as the ALDEFLUOR-assay, analysis of cell surface markers by flow cytometry, cell separation by sorting techniques (Automacs, BD INFLUX, FACS ARIA-II) and clonogenic assays, including growth of animal cells in mammosphere and 3D culture conditions. Also, a significant experience was developed in X-ray irradiation techniques, animal manipulation, cell culture (bacterial and animal), western-blot, imunohistochemistry, fluorescence immunocytochemistry, ELISA, PCR and general lab techniques.

Currently working as a postdoctoral research fellow at Ipatimup on the topic of adhesion molecules and polarity in normal mammary gland and in cancer.

Highlights
Current research is centred in normal breast physiology and in the basal-like subtype of breast cancer. Specifically, my work focuses in the role of P-cadherin, a classical adhesion molecule that confers a poor prognosis signature to basal-like breast carcinomas.
The molecular mechanisms of P-cadherin mediated aggressiveness are under intense research, namely in the alteration of cell polarity, the cross-talk with integrin signalling and the tumour microenvironment, and in the cancer stem cell context.

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First Author
 
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1. Vieira AF, Dionísio MR, Gomes M, Cameselle-Teijeiro JF, Lacerda M, Amendoeira I, Schmitt F, Paredes J
P-cadherin: a useful biomarker for axillary-based breast cancer decisions in the clinical practice. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 30: 698-709, 2017. [Article] 
 
P-cadherin and the journey to cancer metastasis. Molecular cancer 14: 178, 2015. [Review] 
 
3. Vieira AF, Ribeiro AS, Dionísio MR, Sousa B, Nobre AR, Albergaria A, Santiago-Gómez A, Mendes N, Gerhard R, Schmitt F, Clarke RB, Paredes J
 PMID: 24553076.
 
4. Vieira AF, Ricardo S, Ablett MP, Dionísio MR, Mendes N, Albergaria A, Farnie G, Gerhard R, Cameselle-Teijeiro JF, Seruca R, Schmitt F, Clarke RB, Paredes J
 doi: 10.1002/stem.1075 PMID: 22389315.
 
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