1. Seruca R, Velho S, Oliveira C, Leite M, Matos P, Jordan P

Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors. Expert review of gastroenterology & hepatology 3: 5-9, 2009. [] 

 doi: 10.1586/17474124.3.1.5 PMID: 19210107.

 

2. Seruca R, Sobrinho-Simões M

Assessment of microsatellite alterations in young patients with gastric adenocarcinoma. Cancer 80: 1358-60, 1997. [Letter] 

 PMID: 9317193.

 

3. Seruca R, David L, Sobrinho-Simões M

Relationship between the expression of p53 and the aggressiveness of gastric carcinoma. The Journal of pathology 181: 349, 1997. [Letter] 

 doi: 10.1002/(SICI)1096-9896(199703)181:3<349::AID-PATH776>3.0.CO;2-S PMID: 9155724.

 

4. Seruca R, Santos NR, David L, Constância M, Barroca H, Carneiro F, Seixas M, Peltomäki P, Lothe R, Sobrinho-Simões M

Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile. International journal of cancer 64: 32-6, 1995. [Article] 

 PMID: 7665246.

 

5. Seruca R, Suijkerbuijk RF, Gärtner F, Criado B, Veiga I, Olde-Weghuis D, David L, Castedo S, Sobrinho-Simões M

Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer. Cancer genetics and cytogenetics 82: 140-5, 1995. [Article] 

 PMID: 7664243.

 

6. Seruca R, David L, Castedo S, Veiga I, Børresen AL, Sobrinho-Simões M

p53 alterations in gastric carcinoma: a study of 56 primary tumors and 204 nodal metastases. Cancer genetics and cytogenetics 75: 45-50, 1994. [Article] 

 PMID: 8039163.

 

7. Seruca R, Castedo S, Correia C, Gomes P, Carneiro F, Soares P, de Jong B, Sobrinho-Simões M

Cytogenetic findings in eleven gastric carcinomas. Cancer genetics and cytogenetics 68: 42-8, 1993. [Article] 

 PMID: 8330282.

 

1. Figueiredo J, Ferreira RM, Xu H, Gonçalves M, Barros-Carvalho A, Cravo J, Maia AF, Carneiro P, Figueiredo C, Smith ML, Stamenovic D, Morais-de-Sá E, Seruca R

Integrin ß1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 25: 124-137, 2022. [Article] 

 doi: 10.1007/s10120-021-01239-9 PMID: 34486077.

 

2. Moreira AM, Ferreira RM, Carneiro P, Figueiredo J, Osório H, Barbosa J, Preto J, Pinto-do-Ó P, Carneiro F, Seruca R

Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression. Frontiers in molecular biosciences 9: 818552, 2022. [Article] 

 doi: 10.3389/fmolb.2022.818552 PMID: 35340765.

 

3. Figueiredo J, Melo S, Carneiro P, Moreira AM, Fernandes MS, Ribeiro AS, Guilford P, Paredes J, Seruca R

Clinical spectrum and pleiotropic nature of CDH1 germline mutations. Journal of medical genetics 56: 199-208, 2019. [Review] 

 doi: 10.1136/jmedgenet-2018-105807 PMID: 30661051.

 

4. Carneiro P, Moreira AM, Figueiredo J, Barros R, Oliveira P, Fernandes MS, Ferro A, Almeida R, Oliveira C, Carneiro F, Schmitt F, Paredes J, Velho S, Seruca R

S100P is a molecular determinant of E-cadherin function in gastric cancer. Cell communication and signaling : CCS 17: 155, 2019. [Article] 

 doi: 10.1186/s12964-019-0465-9 PMID: 31767037.

 

5. Figueiredo J, Melo S, Gamet K, Godwin T, Seixas S, Sanches JM, Guilford P, Seruca R

E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer. Molecular cancer 17: 112, 2018. [Article] 

 doi: 10.1186/s12943-018-0859-0 PMID: 30068367.

 

6. Melo S, Figueiredo J, Fernandes MS, Gonçalves M, Morais-de-Sá E, Sanches JM, Seruca R

Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer. International journal of molecular sciences 18: ., 2017. [Review] 

 doi: 10.3390/ijms18122687 PMID: 29231860.

 

7. Fernandes MS, Melo S, Velho S, Carneiro P, Carneiro F, Seruca R

Specific inhibition of p110a subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers. Oncotarget 7: 68546-68558, 2016. [Article] 

 doi: 10.18632/oncotarget.11843 PMID: 27602501.

 

8. Caldeira J, Figueiredo J, Brás-Pereira C, Carneiro P, Moreira AM, Pinto MT, Relvas JB, Carneiro F, Barbosa M, Casares F, Janody F, Seruca R

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. Human molecular genetics 24: 5891-900, 2015. [Article] 

 doi: 10.1093/hmg/ddv312 PMID: 26246502.

 

9. Sanches JM, Figueiredo J, Fonseca M, Durães C, Melo S, Esménio S, Seruca R

Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants. European journal of human genetics : EJHG 23: 1072-9, 2015. [Article] 

 doi: 10.1038/ejhg.2014.240 PMID: 25388006.

 

10. Velho S, Fernandes MS, Leite M, Figueiredo C, Seruca R

Causes and consequences of microsatellite instability in gastric carcinogenesis. World journal of gastroenterology 20: 16433-42, 2014. [Article] 

 doi: 10.3748/wjg.v20.i44.16433 PMID: 25469011.

 

11. Simões-Correia J, Silva DI, Melo S, Figueiredo J, Caldeira J, Pinto MT, Girão H, Pereira P, Seruca R

DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. Human molecular genetics 23: 2094-105, 2014. [Article] 

 doi: 10.1093/hmg/ddt602 PMID: 24293545.

 

12. Velho S, Pinto A, Licastro D, Oliveira MJ, Sousa F, Stupka E, Seruca R

Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation. BMC cancer 14: 182, 2014. [Article] 

 doi: 10.1186/1471-2407-14-182 PMID: 24628919.

 

13. Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R

The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC. European journal of human genetics : EJHG 21: 301-9, 2013. [Article] 

 doi: 10.1038/ejhg.2012.159 PMID: 22850631.

 

14. Fernandes MS, Carneiro F, Oliveira C, Seruca R

Colorectal cancer and RASSF family-A special emphasis on RASSF1A. International journal of cancer 132: 251-8, 2013. [Review] 

 doi: 10.1002/ijc.27696 PMID: 22733432.

 

15. Carneiro P, Figueiredo J, Bordeira-Carriço R, Fernandes MS, Carvalho J, Oliveira C, Seruca R

Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. Expert opinion on therapeutic targets 17: 1187-201, 2013. [Review] 

 doi: 10.1517/14728222.2013.827174 PMID: 23957294.

 

16. Carneiro F, Oliveira C, Seruca R

Hereditary diffuse gastric cancer and other gastric cancers associated with hereditary predisposition syndromes. Molecular Pathology of Neoplastic Diseases. Sepúlveda AR, Lynch JP (eds), Springer, New York  83-107, 2013. [] 

.

 

17. Paredes J, Figueiredo J, Albergaria A, Oliveira P, Carvalho J, Ribeiro AS, Caldeira J, Costa AM, Simões-Correia J, Oliveira MJ, Pinheiro H, Pinho SS, Mateus R, Reis CA, Leite M, Fernandes MS, Schmitt F, Carneiro F, Figueiredo C, Oliveira C, Seruca R

Epithelial E- and P-cadherins: Role and clinical significance in cancer. Biochimica et Biophysica acta-Reviews on Cancer 1826: 297-311, 2012. [Review] 

 doi: 10.1016/j.bbcan.2012.05.002 PMID: 22613680.

 

18. Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, Pinheiro H, Leite M, Melo S, Oliveira P, Simões-Correia J, Oliveira MJ, Carneiro F, Figueiredo C, Paredes J, Oliveira C, Seruca R

E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions. FEBS letters 586: 2981-9, 2012. [Review] 

 doi: 10.1016/j.febslet.2012.07.045 PMID: 22841718.

 

19. Simões-Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, Serrano L, Seruca R

E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer. PloS one 7: e33783, 2012. [Article] 

 doi: 10.1371/journal.pone.0033783 PMID: 22470475.

 

20. Caldeira J, Simões-Correia J, Paredes J, Pinto MT, Sousa S, Corso G, Marrelli D, Roviello F, Pereira PS, Weil D, Oliveira C, Casares F, Seruca R

CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach. Gut 61: 1115-23, 2012. [Article] 

 doi: 10.1136/gutjnl-2011-300427 PMID: 22052064.

 

21. Corso G, Velho S, Paredes J, Pedrazzani C, Martins D, Milanezi F, Pascale V, Vindigni C, Pinheiro H, Leite M, Marrelli D, Sousa S, Carneiro F, Oliveira C, Roviello F, Seruca R

Oncogenic mutations in gastric cancer with microsatellite instability. European journal of cancer (Oxford, England : 1990) 47: 443-51, 2011. [Article] 

 doi: 10.1016/j.ejca.2010.09.008 PMID: 20937558.

 

22. Leite M, Corso G, Sousa S, Milanezi F, Afonso LP, Henrique R, Soares JM, Castedo S, Carneiro F, Roviello F, Oliveira C, Seruca R

MSI phenotype and MMR alterations in familial and sporadic gastric cancer. International journal of cancer 128: 1606-13, 2011. [Article] 

 doi: 10.1002/ijc.25495 PMID: 20533283.

 

23. Figueiredo J, Simões-Correia J, Söderberg O, Suriano G, Seruca R

ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones. PloS one 6: e23188, 2011. [Article] 

 doi: 10.1371/journal.pone.0023188 PMID: 21853084.

 

24. da Cunha CB, Oliveira C, Wen X, Gomes B, Sousa S, Suriano G, Grellier M, Huntsman DG, Carneiro F, Granja PL, Seruca R

De novo expression of CD44 variants in sporadic and hereditary gastric cancer. Laboratory investigation; a journal of technical methods and pathology 90: 1604-14, 2010. [Article] 

 doi: 10.1038/labinvest.2010.155 PMID: 20856229.

 

25. Velho S, Oliveira C, Paredes J, Sousa S, Leite M, Matos P, Milanezi F, Ribeiro AS, Mendes N, Licastro D, Karhu A, Oliveira MJ, Ligtenberg M, Hamelin R, Carneiro F, Lindblom A, Peltomaki P, Castedo S, Schwartz S, Jordan P, Aaltonen LA, Hofstra RM, Suriano G, Stupka E, Fialho AM, Seruca R

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours. Human molecular genetics 19: 697-706, 2010. [Article] 

 doi: 10.1093/hmg/ddp536 PMID: 19955118.

 

26. Velho S, Corso G, Oliveíra C, Seruca R

KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers. Advances in cancer research 109: 123-43, 2010. [Review; Book Chapter] 

 doi: 10.1016/B978-0-12-380890-5.00004-1 PMID: 21070916.

 

27. Carneiro F, Oliveira C, Seruca R

Pathology and genetics of familial gastric cancer. International journal of surgical pathology 18: 33S-36S, 2010. [Article; Proceedings Paper] 

 doi: 10.1177/1066896910366463 PMID: 20484258.

 

28. Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carriço R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmão L, Wen X, Cipriano MA, Yokota J, Carneiro F, Huntsman D, Seruca R

Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology 136: 2137-48, 2009. [Article] 

 doi: 10.1053/j.gastro.2009.02.065 PMID: 19269290.

 

29. Pinho SS, Reis CA, Paredes J, Magalhães AM, Ferreira AC, Figueiredo J, Xiaogang W, Carneiro F, Gärtner F, Seruca R

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. Human molecular genetics 18: 2599-608, 2009. [Article] 

 doi: 10.1093/hmg/ddp194 PMID: 19403558.

 

30. Mateus AR, Simões-Correia J, Figueiredo J, Heindl S, Alves CC, Suriano G, Luber B, Seruca R

E-cadherin mutations and cell motility: a genotype-phenotype correlation. Experimental cell research 315: 1393-402, 2009. [Article] 

 doi: 10.1016/j.yexcr.2009.02.020 PMID: 19268661.

 

31. Velho S, Oliveira C, Seruca R

KRAS mutations and anti-epidermal growth factor receptor therapy in colorectal cancer with lymph node metastases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27: 158-9; author reply 159, 2009. [Letter] 

 doi: 10.1200/JCO.2008.20.1525 PMID: 19047277.

 

32. Oliveira C, Sousa S, Pinheiro H, Bordeira-Carrico R, Carvalho J, Carneiro F, Huntsman D, Seruca R

Quantification of Epigenetic and Genetic Second Hits in CDH1 During Hereditary Diffuse Gastric Cancer Syndrome Progression Helicobacter 14: 383-383, 2009. [Meeting Abstract] 

.

 

33. Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis? BMC cancer 8: 255, 2008. [Article] 

 doi: 10.1186/1471-2407-8-255 PMID: 18782444.

 

34. Carneiro F, Oliveira C, Suriano G, Seruca R

Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. Journal of clinical pathology 61: 25-30, 2008. [Article] 

 doi: 10.1136/jcp.2006.043679 PMID: 17513507.

 

35. Preto A, Figueiredo J, Velho S, Ribeiro AS, Soares P, Oliveira C, Seruca R

BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. The Journal of pathology 214: 320-7, 2008. [Article] 

 doi: 10.1002/path.2295 PMID: 18098337.

 

36. Carneiro F, Oliveira C, Leite M, Seruca R

Molecular targets and biological modifiers in gastric cancer. Seminars in diagnostic pathology 25: 274-87, 2008. [Review] 

 PMID: 19013893.

 

37. Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha AF, Duval A, Hamelin R, Machado JC, Schwartz S, Carneiro F, Seruca R

KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. Oncogene 26: 158-63, 2007. [Article] 

 doi: 10.1038/sj.onc.1209758 PMID: 16953233.

 

38. Preto A, Moutinho C, Velho S, Oliveira C, Rebocho AP, Figueiredo J, Soares P, Lopes JM, Seruca R

A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation. Virchows Archiv : an international journal of pathology 450: 619-26, 2007. [Article] 

 doi: 10.1007/s00428-007-0420-9 PMID: 17487504.

 

39. Frebourg T, Oliveira C, Hochain P, Karam R, Manouvrier S, Graziadio C, Vekemans M, Hartmann A, Baert-Desurmont S, Alexandre C, Lejeune Dumoulin S, Marroni C, Martin C, Castedo S, Lovett M, Winston J, Machado JC, Attié T, Jabs EW, Cai J, Pellerin P, Triboulet JP, Scotte M, Le Pessot F, Hedouin A, Carneiro F, Blayau M, Seruca R

Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer. Journal of medical genetics 43: 138-42, 2006. [Article] 

 doi: 10.1136/jmg.2005.031385 PMID: 15831593.

 

40. Suriano G, Seixas S, Rocha J, Seruca R

A model to infer the pathogenic significance of CDH1 germline missense variants. Journal of molecular medicine (Berlin, Germany) 84: 1023-31, 2006. [Article] 

 doi: 10.1007/s00109-006-0091-z PMID: 16924464.

 

41. Suriano G, Ferreira P, Mateus AR, Correia J, Henriques L, Seruca R

Genetics of hereditary diffuse gastric cancer: progress and future challenges. Future oncology (London, England) 2: 363-70, 2006. [] 

 doi: 10.2217/14796694.2.3.363 PMID: 16787116.

 

42. Velho S, Oliveira C, Ferreira A, Ferreira AC, Suriano G, Schwartz S, Duval A, Carneiro F, Machado JC, Hamelin R, Seruca R

The prevalence of PIK3CA mutations in gastric and colon cancer. European journal of cancer (Oxford, England : 1990) 41: 1649-54, 2005. [Article] 

 doi: 10.1016/j.ejca.2005.04.022 PMID: 15994075.

 

43. Oliveira C, Ferreira P, Nabais S, Campos L, Ferreira A, Cirnes L, Alves CC, Veiga I, Fragoso M, Regateiro F, Dias LM, Moreira H, Suriano G, Machado JC, Lopes C, Castedo S, Carneiro F, Seruca R

E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. European journal of cancer (Oxford, England : 1990) 40: 1897-903, 2004. [Article] 

 doi: 10.1016/j.ejca.2004.04.027 PMID: 15288293.

 

44. Oliveira C, Suriano G, Ferreira P, Canedo P, Kaurah P, Mateus R, Ferreira A, Ferreira AC, Oliveira MJ, Figueiredo C, Carneiro F, Keller G, Huntsman D, Machado JC, Seruca R

Genetic screening for familial gastric cancer. Hereditary Cancer in Clinical Practice 2: 51-64, 2004. [] 

 doi: 10.1186/1897-4287-2-2-51 PMID: 20233471.

 

45. Carneiro F, Oliveira C, Suriano G, Huntsman D, Caldas C, Seruca R

 Hereditary diffuse gastric cancer. Pathol Internat 54:  S193-S203, 2004. [] 

.

 

46. Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O, Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH, Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Human molecular genetics 12: 575-82, 2003. [Article] 

 PMID: 12588804.

 

47. Suriano G, Oliveira MJ, Huntsman D, Mateus AR, Ferreira P, Casares F, Oliveira C, Carneiro F, Machado JC, Mareel M, Seruca R

E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells. Human molecular genetics 12: 3007-16, 2003. [Article] 

 doi: 10.1093/hmg/ddg316 PMID: 14500541.

 

48. Suriano G, Mulholland D, de Wever O, Ferreira P, Mateus AR, Bruyneel E, Nelson CC, Mareel MM, Yokota J, Huntsman D, Seruca R

The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion. Oncogene 22: 5716-9, 2003. [Article] 

 doi: 10.1038/sj.onc.1206672 PMID: 12944922.

 

49. Pinto M, Oliveira C, Cirnes L, Carlos Machado J, Ramires M, Nogueira A, Carneiro F, Seruca R

Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas. The Journal of pathology 200: 32-8, 2003. [Article] 

 doi: 10.1002/path.1327 PMID: 12692838.

 

50. Carvalho B, Pinto M, Cirnes L, Oliveira C, Machado JC, Suriano G, Hamelin R, Carneiro F, Seruca R

Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. European journal of cancer (Oxford, England : 1990) 39: 1222-7, 2003. [Article] 

 PMID: 12763209.

 

51. Thorstensen L, Holm R, Lothe RA, Tropé C, Carvalho B, Sobrinho-Simoes M, Seruca R

WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas. Gastroenterology 124: 270-1, 2003. [Letter] 

 doi: 10.1053/gast.2003.50034 PMID: 12512062.

 

52. Oliveira C, Suriano G, Huntsman D, Kaurah P, Machado JC, Figueiredo C, Carneiro F, Caldas C, Seruca R

Genetic screening for familial gastric cancer. Proceedings of Fifth International Gastric Cancer Congress 1: 37-44, 2003. [] 

.

 

53. Schmitt FC, Soares R, Gobbi H, Milanezzi F, Santos-Silva F, Cirnes L, Costa C, Seruca R

Microsatellite instability in medullary breast carcinomas. International journal of cancer 82: 644-7, 1999. [Article] 

 PMID: 10417760.

 

54. Sobrinho-Simões M, Carneiro F, David L, Soares P, Seruca R

A proeminência da morfologia e a quasi-futilidade das análises genéticas e moleculares no dia-a-dia da patologia oncológica. Revista da Faculdade de Medicina de Lisboa 4:  93-102, 1999. [] 

.

 

55. Schmitt FC, Soares R, Cirnes L, Seruca R

P53 in breast carcinomas: association between presence of mutation and immunohistochemical expression using a semiquantitative approach. Pathology, research and practice 194: 815-9, 1998. [Article] 

 PMID: 9894246.

 

56. Schmitt FC, Soares R, Cirnes L, Seruca R

PCR amplification of DNA obtained from archived hematoxylin-eosin--and giemsa-stained breast cancer aspirates. Diagnostic cytopathology 19: 395-7, 1998. [Article] 

 doi: 10.1002/(SICI)1097-0339(199811)19:5<395::AID-DC19>3.0.CO;2-4 PMID: 9812239.

 

57. Schmitt FC, Soares R, Seruca R

Bilateral apocrine carcinoma of the breast. Molecular and immunocytochemical evidence for two independent primary tumours. Virchows Archiv : an international journal of pathology 433: 505-9, 1998. [Article] 

 PMID: 9870682.

 

58. Lopes JM, Silva P, Seixas M, Cirnes L, Seruca R

Microsatellite instability is not associated with degree of malignancy and p53 expression of gastrointestinal stromal tumours. Histopathology 33: 579-81, 1998. [Letter] 

 PMID: 9870157.