Raquel Seruca
Name: Raquel Seruca
E-mail: rseruca@ipatimup.pt
Academic Degree: Doctor of philosophy

Raquel Seruca
Raquel Seruca
Member of
Consultant of Ipatimup Diagnostics
Coordinator Researcher of Epithelial Interactions in Cancer

Short CV


Supervisor of
Filipe Coutinho, Consultant
Joana Caldeira, Post Doc
João Sanches, External Researcher
Sofia Fernandes, Post Doc
Patrícia Carneiro, Assistant Researcher
Soraia Melo, PhD Student

PI (running)

PI (closed)
First Author
1. Seruca R, Velho S, Oliveira C, Leite M, Matos P, Jordan P
Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors. Expert review of gastroenterology & hepatology 3: 5-9, 2009. [] 
 PMID: 9317193.
4. Seruca R, Santos NR, David L, Constância M, Barroca H, Carneiro F, Seixas M, Peltomäki P, Lothe R, Sobrinho-Simões M
 PMID: 7665246.
5. Seruca R, Suijkerbuijk RF, Gärtner F, Criado B, Veiga I, Olde-Weghuis D, David L, Castedo S, Sobrinho-Simões M
 PMID: 7664243.
6. Seruca R, David L, Castedo S, Veiga I, Børresen AL, Sobrinho-Simões M
p53 alterations in gastric carcinoma: a study of 56 primary tumors and 204 nodal metastases. Cancer genetics and cytogenetics 75: 45-50, 1994. [Article] 
 PMID: 8039163.
7. Seruca R, Castedo S, Correia C, Gomes P, Carneiro F, Soares P, de Jong B, Sobrinho-Simões M
Cytogenetic findings in eleven gastric carcinomas. Cancer genetics and cytogenetics 68: 42-8, 1993. [Article] 
 PMID: 8330282.
Senior Author
2. Sanches JM, Figueiredo J, Fonseca M, Durães C, Melo S, Esménio S, Seruca R
3. Caldeira J, Figueiredo J, Brás-Pereira C, Carneiro P, Moreira AM, Pinto MT, Relvas JB, Carneiro F, Barbosa M, Casares F, Janody F, Seruca R
E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. Human molecular genetics 24: 5891-900, 2015. [Article] 
 doi: 10.1093/hmg/ddv312 PMID: 26246502.
Causes and consequences of microsatellite instability in gastric carcinogenesis. World journal of gastroenterology : WJG 20: 16433-42, 2014. [Article] 
5. Simões-Correia J, Silva DI, Melo S, Figueiredo J, Caldeira J, Pinto MT, Girão H, Pereira P, Seruca R
 doi: 10.1093/hmg/ddt602 PMID: 24293545.
6. Velho S, Pinto A, Licastro D, Oliveira MJ, Sousa F, Stupka E, Seruca R
Colorectal cancer and RASSF family-A special emphasis on RASSF1A. International journal of cancer 132: 251-8, 2013. [Review] 
 doi: 10.1002/ijc.27696 PMID: 22733432.
8. Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R
Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. Expert opinion on therapeutic targets 17: 1187-201, 2013. [Review] 
Hereditary diffuse gastric cancer and other gastric cancers associated with hereditary predisposition syndromes. Molecular Pathology of Neoplastic Diseases. Sepúlveda AR, Lynch JP (eds), Springer, New York  83-107, 2013. [] 
Epithelial E- and P-cadherins: Role and clinical significance in cancer. Biochimica et Biophysica acta-Reviews on Cancer 1826: 297-311, 2012. [Review] 
13. Simões-Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, Serrano L, Seruca R
14. Caldeira J, Simões-Correia J, Paredes J, Pinto MT, Sousa S, Corso G, Marrelli D, Roviello F, Pereira PS, Weil D, Oliveira C, Casares F, Seruca R
15. Corso G, Velho S, Paredes J, Pedrazzani C, Martins D, Milanezi F, Pascale V, Vindigni C, Pinheiro H, Leite M, Marrelli D, Sousa S, Carneiro F, Oliveira C, Roviello F, Seruca R
Oncogenic mutations in gastric cancer with microsatellite instability. European journal of cancer (Oxford, England : 1990) 47: 443-51, 2011. [Article] 
16. Leite M, Corso G, Sousa S, Milanezi F, Afonso LP, Henrique R, Soares JM, Castedo S, Carneiro F, Roviello F, Oliveira C, Seruca R
MSI phenotype and MMR alterations in familial and sporadic gastric cancer. International journal of cancer 128: 1606-13, 2011. [Article] 
 doi: 10.1002/ijc.25495 PMID: 20533283.
17. Figueiredo J, Simões-Correia J, Söderberg O, Suriano G, Seruca R
18. da Cunha CB, Oliveira C, Wen X, Gomes B, Sousa S, Suriano G, Grellier M, Huntsman DG, Carneiro F, Granja PL, Seruca R
De novo expression of CD44 variants in sporadic and hereditary gastric cancer. Laboratory investigation; a journal of technical methods and pathology 90: 1604-14, 2010. [Article] 
19. Velho S, Oliveira C, Paredes J, Sousa S, Leite M, Matos P, Milanezi F, Ribeiro AS, Mendes N, Licastro D, Karhu A, Oliveira MJ, Ligtenberg M, Hamelin R, Carneiro F, Lindblom A, Peltomaki P, Castedo S, Schwartz S, Jordan P, Aaltonen LA, Hofstra RM, Suriano G, Stupka E, Fialho AM, Seruca R
 doi: 10.1093/hmg/ddp536 PMID: 19955118.
Pathology and genetics of familial gastric cancer. International journal of surgical pathology 18: 33S-36S, 2010. [Article; Proceedings Paper] 
21. Velho S, Corso G, Oliveíra C, Seruca R
KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers. Advances in cancer research 109: 123-43, 2010. [Review; Book Chapter] 
22. Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carriço R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmão L, Wen X, Cipriano MA, Yokota J, Carneiro F, Huntsman D, Seruca R
 doi: 10.1093/hmg/ddp194 PMID: 19403558.
24. Mateus AR, Simões-Correia J, Figueiredo J, Heindl S, Alves CC, Suriano G, Luber B, Seruca R
E-cadherin mutations and cell motility: a genotype-phenotype correlation. Experimental cell research 315: 1393-402, 2009. [Article] 
KRAS mutations and anti-epidermal growth factor receptor therapy in colorectal cancer with lymph node metastases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 27: 158-9; author reply 159, 2009. [Letter] 
26. Oliveira C, Sousa S, Pinheiro H, Bordeira-Carrico R, Carvalho J, Carneiro F, Huntsman D, Seruca R
27. Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R
 doi: 10.1002/path.2295 PMID: 18098337.
Molecular targets and biological modifiers in gastric cancer. Seminars in diagnostic pathology 25: 274-87, 2008. [Review] 
 PMID: 19013893.
31. Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha AF, Duval A, Hamelin R, Machado JC, Schwartz S, Carneiro F, Seruca R
32. Preto A, Moutinho C, Velho S, Oliveira C, Rebocho AP, Figueiredo J, Soares P, Lopes JM, Seruca R
A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation. Virchows Archiv : an international journal of pathology 450: 619-26, 2007. [Article] 
33. Frebourg T, Oliveira C, Hochain P, Karam R, Manouvrier S, Graziadio C, Vekemans M, Hartmann A, Baert-Desurmont S, Alexandre C, Lejeune Dumoulin S, Marroni C, Martin C, Castedo S, Lovett M, Winston J, Machado JC, Attié T, Jabs EW, Cai J, Pellerin P, Triboulet JP, Scotte M, Le Pessot F, Hedouin A, Carneiro F, Blayau M, Seruca R
A model to infer the pathogenic significance of CDH1 germline missense variants. Journal of molecular medicine (Berlin, Germany) 84: 1023-31, 2006. [Article] 
35. Suriano G, Ferreira P, Mateus AR, Correia J, Henriques L, Seruca R
Genetics of hereditary diffuse gastric cancer: progress and future challenges. Future oncology (London, England) 2: 363-70, 2006. [] 
36. Velho S, Oliveira C, Ferreira A, Ferreira AC, Suriano G, Schwartz S, Duval A, Carneiro F, Machado JC, Hamelin R, Seruca R
The prevalence of PIK3CA mutations in gastric and colon cancer. European journal of cancer (Oxford, England : 1990) 41: 1649-54, 2005. [Article] 
37. Oliveira C, Ferreira P, Nabais S, Campos L, Ferreira A, Cirnes L, Alves CC, Veiga I, Fragoso M, Regateiro F, Dias LM, Moreira H, Suriano G, Machado JC, Lopes C, Castedo S, Carneiro F, Seruca R
38. Oliveira C, Suriano G, Ferreira P, Canedo P, Kaurah P, Mateus R, Ferreira A, Ferreira AC, Oliveira MJ, Figueiredo C, Carneiro F, Keller G, Huntsman D, Machado JC, Seruca R
Genetic screening for familial gastric cancer. Hereditary Cancer in Clinical Practice 2: 51-64, 2004. [] 
39. Carneiro F, Oliveira C, Suriano G, Huntsman D, Caldas C, Seruca R
 Hereditary diffuse gastric cancer. Pathol Internat 54:  S193-S203, 2004. [] 
40. Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O, Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH, Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R
 PMID: 12588804.
41. Suriano G, Oliveira MJ, Huntsman D, Mateus AR, Ferreira P, Casares F, Oliveira C, Carneiro F, Machado JC, Mareel M, Seruca R
 doi: 10.1093/hmg/ddg316 PMID: 14500541.
42. Suriano G, Mulholland D, de Wever O, Ferreira P, Mateus AR, Bruyneel E, Nelson CC, Mareel MM, Yokota J, Huntsman D, Seruca R
43. Pinto M, Oliveira C, Cirnes L, Carlos Machado J, Ramires M, Nogueira A, Carneiro F, Seruca R
 doi: 10.1002/path.1327 PMID: 12692838.
44. Carvalho B, Pinto M, Cirnes L, Oliveira C, Machado JC, Suriano G, Hamelin R, Carneiro F, Seruca R
Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. European journal of cancer (Oxford, England : 1990) 39: 1222-7, 2003. [Article] 
 PMID: 12763209.
45. Thorstensen L, Holm R, Lothe RA, Tropé C, Carvalho B, Sobrinho-Simoes M, Seruca R
46. Oliveira C, Suriano G, Huntsman D, Kaurah P, Machado JC, Figueiredo C, Carneiro F, Caldas C, Seruca R
Genetic screening for familial gastric cancer. Proceedings of Fifth International Gastric Cancer Congress 1: 37-44, 2003. [] 
47. Schmitt FC, Soares R, Gobbi H, Milanezzi F, Santos-Silva F, Cirnes L, Costa C, Seruca R
Microsatellite instability in medullary breast carcinomas. International journal of cancer 82: 644-7, 1999. [Article] 
 PMID: 10417760.
49. Schmitt FC, Soares R, Cirnes L, Seruca R
 PMID: 9894246.
50. Schmitt FC, Soares R, Cirnes L, Seruca R
51. Schmitt FC, Soares R, Seruca R
Bilateral apocrine carcinoma of the breast. Molecular and immunocytochemical evidence for two independent primary tumours. Virchows Archiv : an international journal of pathology 433: 505-9, 1998. [Article] 
 PMID: 9870682.
52. Lopes JM, Silva P, Seixas M, Cirnes L, Seruca R
 PMID: 9870157.
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