Manuel Sobrinho-Simões
Name: Manuel Sobrinho-Simões
Academic Degree: Doctor of philosophy

Manuel Sobrinho-Simões
Manuel Sobrinho-Simões
Member of
Coordinator of Ipatimup Diagnostics

Short CV


Supervisor of

PI (running)

PI (closed)
First Author
1. Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Follicular thyroid carcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 24 Suppl 2: S10-8, 2011. [Article] 
2. Sobrinho-Simões M, Magalhães J, Soares P
Hot topics in papillary thyroid carcinoma. International journal of surgical pathology 18: 190S-193S, 2010. [Article; Proceedings Paper] 
Intragenic mutations in thyroid cancer. Endocrinology and metabolism clinics of North America 37: 333-62, viii, 2008. [Review] 
Warthin's tumour. Virchows Archiv : an international journal of pathology 448: 877-8, 2006. [Letter] 
Molecular pathology of well-differentiated thyroid carcinomas. Virchows Archiv : an international journal of pathology 447: 787-93, 2005. [Review] 
6. Sobrinho-Simões M, Máximo V, Castro IV, Fonseca E, Soares P, Garcia-Rostan G, Oliveira MC
Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance. International journal of surgical pathology 13: 29-35, 2005. [Review] 
 PMID: 15735852.
 PMID: 15861529.
 PMID: 12075405.
Different types of epithelial cadherin alterations play different roles in human carcinogenesis. Advances in anatomic pathology 9: 329-37, 2002. [Article] 
 PMID: 12409641.
Difficult cases of thyroid pathology. Endocrine pathology 13: 369-70; author reply 371, 2002. [Letter] 
 PMID: 12665655.
Hail to the histologic grading of papillary thyroid carcinoma? Cancer 88: 1766-8, 2000. [Editorial Material] 
 PMID: 10760750.
12. Sobrinho Simões M, Ribeiro P
Venous invasion as a prognostic factor in colorectal carcinoma European journal of cancer (Oxford, England : 1990) 33: 729-729, 1997. [Meeting Abstract] 
 PMID: 8826873.
Mixed medullary and follicular carcinoma of the thyroid. Histopathology 23: 287-9, 1993. [Note] 
 PMID: 8225250.
Senior Author
1. Tavares C, Melo M, Cameselle-Teijeiro JM, Soares P, Sobrinho-Simões M
ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome. European journal of endocrinology 174: R117-26, 2016. [Review] 
 doi: 10.1530/EJE-15-0605 PMID: 26510840.
2. Ortiz S, Tortosa F, Sobrinho Simões M
An extraordinary case of mesenchymal chondrosarcoma metastasis in the thyroid. Endocrine pathology 26: 33-6, 2015. [Article] 
Poorly Differentiated and Undifferentiated Thyroid Carcinomas. Tu¨rk patoloji dergisi 31 Suppl 1: 48-59, 2015. [Article] 
Papillary Thyroid Microcarcinoma: How to Diagnose and Manage this Epidemic? International journal of surgical pathology 22: 113-9, 2014. [Article] 
Prognostic biomarkers in thyroid cancer. Virchows Archiv : an international journal of pathology 464: 333-46, 2014. [Review] 
Oncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands. International journal of surgical pathology 22: 33-6, 2014. [Review] 
7. Nakazawa T, Cameselle-Teijeiro J, Vinagre J, Soares P, Rousseau E, Eloy C, Sobrinho-Simões M
8. Eloy C, Oliveira M, Vieira J, Teixeira MR, Cruz J, Sobrinho-Simões M
Carcinoma of the thyroid with ewing family tumor elements and favorable prognosis: report of a second case. International journal of surgical pathology 22: 260-5, 2014. [Article] 
9. Eloy C, Cruz J, Vieira J, Teixeira MR, Cameselle-Teijeiro J, Sobrinho-Simões M
Carcinoma of the Thyroid With Ewing/PNET Family Tumor Elements: A Tumor of Unknown Histogenesis. International journal of surgical pathology 22: 579-81, 2014. [Letter] 
10. Barroca H, Souto Moura C, Lopes JM, Lisboa S, Teixeira MR, Damasceno M, Bastos P, Sobrinho-Simões M
PNET with neuroendocrine differentiation of the lung: Report of an unusual entity. International journal of surgical pathology 22: 427-33, 2014. [Article] 
11. Eloy C, Cameselle-Teijeiro JM, Rousseau E, Sobrinho-Simões M
Small cell tumors of the thyroid gland: a review. International journal of surgical pathology 22: 197-201, 2014. [Review] 
12. Nakazawa T, Celestino R, Machado JC, Cameselle-Teijeiro JM, Vinagre J, Eloy C, Benserai F, Lameche S, Soares P, Sobrinho-Simões M
Cribriform-morular variant of papillary thyroid carcinoma displaying poorly differentiated features. International journal of surgical pathology 21: 379-89, 2013. [Article] 
13. Bialas M, Okon K, Dyduch G, Ciesielska-Milian K, Buziak M, Hubalewska-Dydejczyk A, Sobrinho-Simoes M
Neuroendocrine markers and sustentacular cell count in benign and malignant pheochromocytomas - a comparative study. Polish journal of pathology : official journal of the Polish Society of Pathologists 64: 129-35, 2013. [Article] 
 PMID: 23900871.
14. Vilallonga R, Zafon C, Ruiz-Marcellan C, Obiols G, Fort JM, Baena JA, Villanueva B, Garcia A, Sobrinho-Simões M
Malignant thyroid teratoma: report of an aggressive tumor in a 64-year-old man. Endocrine pathology 24: 132-5, 2013. [Article] 
The biology and the genetics of Hurthle cell tumors of the thyroid. Endocrine-related cancer 19: R131-47, 2012. [Review] 
 doi: 10.1530/ERC-11-0354 PMID: 22514109.
16. Eloy C, Santos J, Cameselle-Teijeiro J, Soares P, Sobrinho-Simões M
TGF-beta/Smad pathway and BRAF mutation play different roles in circumscribed and infiltrative papillary thyroid carcinoma. Virchows Archiv : an international journal of pathology 460: 587-600, 2012. [Article] 
17. Cameselle-Teijeiro J, Ferreira R, Caramés N, Abdulkader I, Máximo V, Soares P, Sobrinho-Simões M
Absence of the BRAF and the GRIM-19 Mutations in Oncocytic (Hurthle Cell) Solid Cell Nests of the Thyroid. American journal of clinical pathology 137: 612-8, 2012. [Article] 
18. Cameselle-Teijeiro J, Caramés-Díaz N, Eloy C, Sobrinho-Simões M
C-cell hyperplasia and papillary thyroid carcinoma. International journal of surgical pathology 20: 643-4, 2012. [Letter] 
Cancer: Small papillary thyroid cancers--is BRAF of prognostic value? Nature reviews. Endocrinology 7: 9-10, 2011. [Editorial Material] 
23. Cruz J, Eloy C, Aragüés JM, Vinagre J, Sobrinho-Simões M
Small-cell (basaloid) thyroid carcinoma: a neoplasm with a solid cell nest histogenesis? International journal of surgical pathology 19: 620-6, 2011. [Article] 
Head and neck lesions in a cohort irradiated in childhood for tinea capitis treatment. The Lancet infectious diseases 11: 163-4, 2011. [Letter] 
25. Eloy C, Vinagre J, Cameselle-Teijeiro J, Paiva ME, Soares P, Sobrinho-Simões M
Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component? International journal of surgical pathology 19: 276-80, 2011. [Article] 
Mitochondria and cancer. Virchows Archiv : an international journal of pathology 454: 481-95, 2009. [Review] 
27. Cameselle-Teijeiro J, Menasce LP, Yap BK, Colaco RJ, Castro P, Celestino R, Ruíz-Ponte C, Soares P, Sobrinho-Simões M
28. Cameselle-Teijeiro J, Abdulkader I, Pérez-Becerra R, Vázquez-Boquete A, Alberte-Lista L, Ruiz-Ponte C, Forteza J, Sobrinho-Simões M
29. Preto A, Gonçalves J, Rebocho AP, Figueiredo J, Meireles AM, Rocha AS, Vasconcelos HM, Seca H, Seruca R, Soares P, Sobrinho-Simões M
31. Celestino R, Magalhães J, Castro P, Triller M, Vinagre J, Soares P, Sobrinho-Simões M
Is BRAF mutation screening useful for preoperative risk stratification in papillary thyroid cancer? Future oncology (London, England) 5: 1225-9, 2009. [Article] 
 doi: 10.2217/fon.09.81 PMID: 19852736.
33. Trovisco V, Couto JP, Cameselle-Teijeiro J, de Castro IV, Fonseca E, Soares P, Sobrinho-Simões M
34. Máximo V, Lima J, Soares P, Silva A, Bento I, Sobrinho-Simões M
GRIM-19 in Health and Disease. Advances in anatomic pathology 15: 46-53, 2008. [Editorial Material] 
35. Cameselle-Teijeiro J, Pardal F, Eloy C, Ruiz-Ponte C, Celestino R, Castro P, Soares P, Sobrinho-Simões M
Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth. Human pathology 39: 1540-7, 2008. [Article] 
36. Meireles AM, Preto A, Rocha AS, Rebocho AP, Máximo V, Pereira-Castro I, Moreira S, Feijão T, Botelho T, Marques R, Trovisco V, Cirnes L, Alves C, Velho S, Soares P, Sobrinho-Simões M
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines. Thyroid : official journal of the American Thyroid Association 17: 707-15, 2007. [Article] 
Molecular genetics of papillary thyroid carcinoma: great expectations. Arquivos brasileiros de endocrinologia e metabologia 51: 643-53, 2007. [Review] 
 PMID: 17891228.
39. Castro P, Vieira de Castro I, Rebocho AP, Soares RJ, Magalhães J, Roque L, Trovisco V, Cardoso-de-Oliveira M, Fonseca E, Soares P, Sobrinho-Simões M
PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma. The Journal of clinical endocrinology and metabolism 91: 213-20, 2006. [Article] 
40. Trovisco V, Soares P, Sobrinho-Simões M
42. Fonseca E, Soares P, Cardoso-Oliveira M, Sobrinho-Simões M
Diagnostic criteria in well-differentiated thyroid carcinomas. Endocrine pathology 17: 109-17, 2006. [Article] 
 PMID: 17159243.
43. Rocha AS, Risberg B, Magalhães J, Trovisco V, de Castro IV, Lazarovici P, Soares P, Davidson B, Sobrinho-Simões M
44. Cameselle-Teijeiro J, Abdulkader I, Barreiro-Morandeira F, Ruiz-Ponte C, Reyes-Santías R, Chavez E, Sobrinho-Simões M
Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: a case report. International journal of surgical pathology 14: 79-84, 2006. [Article] 
 PMID: 16501842.
45. Trovisco V, Soares P, Preto A, de Castro IV, Lima J, Castro P, Máximo V, Botelho T, Moreira S, Meireles AM, Magalhães J, Abrosimov A, Cameselle-Teijeiro J, Sobrinho-Simões M
46. Máximo V, Botelho T, Capela J, Soares P, Lima J, Taveira A, Amaro T, Barbosa AP, Preto A, Harach HR, Williams D, Sobrinho-Simões M
47. Trovisco V, Soares P, Soares R, Magalhães J, Sá-Couto P, Sobrinho-Simões M
48. Castro P, Roque L, Magalhães J, Sobrinho-Simões M
A subset of the follicular variant of papillary thyroid carcinoma harbors the PAX8-PPARgamma translocation. International journal of surgical pathology 13: 235-8, 2005. [Article] 
 PMID: 16086077.
49. Castro P, Eknaes M, Teixeira MR, Danielsen HE, Soares P, Lothe RA, Sobrinho-Simões M
 doi: 10.1002/path.1772 PMID: 15852498.
50. Máximo V, Lima J, Soares P, Botelho T, Gomes L, Sobrinho-Simões M
51. Cameselle-Teijeiro J, Preto A, Soares P, Sobrinho-Simões M
A stem cell role for thyroid solid cell nests. Human pathology 36: 590-1, 2005. [Letter] 
52. Cameselle-Teijeiro J, Abdulkader I, Soares P, Alfonsín-Barreiro N, Moldes-Boullosa J, Sobrinho-Simões M
53. Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M
 PMID: 15861529.
BRAF Mutations in thyroid carcinomas: phenotype-genotype correlations. Advances in anatomic pathology 12: 106-107, 2005. [] 
56. Trovisco V, Vieira de Castro I, Soares P, Máximo V, Silva P, Magalhães J, Abrosimov A, Guiu XM, Sobrinho-Simões M
BRAF mutations are associated with some histological types of papillary thyroid carcinoma. The Journal of pathology 202: 247-51, 2004. [Article] 
 doi: 10.1002/path.1511 PMID: 14743508.
57. Carneiro F, Huntsman DG, Smyrk TC, Owen DA, Seruca R, Pharoah P, Caldas C, Sobrinho-Simões M
 doi: 10.1002/path.1564 PMID: 15141383.
58. Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M
BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. The Journal of clinical endocrinology and metabolism 89: 4267-71, 2004. [Article] 
59. Soares P, Trovisco V, Rocha AS, Feijão T, Rebocho AP, Fonseca E, Vieira de Castro I, Cameselle-Teijeiro J, Cardoso-Oliveira M, Sobrinho-Simões M
60. Preto A, Cameselle-Teijeiro J, Moldes-Boullosa J, Soares P, Cameselle-Teijeiro JF, Silva P, Reis-Filho JS, Reyes-Santías RM, Alfonsín-Barreiro N, Forteza J, Sobrinho-Simões M
Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 17: 819-26, 2004. [Article] 
62. Woenckhaus C, Cameselle-Teijeiro J, Ruiz-Ponte C, Abdulkader I, Reyes-Santías R, Sobrinho-Simões M
Spindle cell variant of papillary thyroid carcinoma. Histopathology 45: 424-7, 2004. [Letter] 
63. Magalhães J, Sobrinho-Simões M
Hyalinizing trabecular tumor of the thyroid displaying neuroendocrine differentiation. Virchows Archiv : an international journal of pathology 445: 98, 2004. [Letter] 
Hereditary diffuse gastric cancer: Lessons from histopathology. Advances in anatomic pathology 12: 151-152, 2004. [] 
65. Carneiro F, Huntsman DG, Smyrk T, Owen D, Seruca R, Pharoah P, Caldas C, Sobrinho-Simões M
Pathology of inherited gastric cancer. Pathol Internat 54: S285-S286, 2004. [] 
66. Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, Máximo V, Botelho T, Seruca R, Sobrinho-Simões M
67. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Castro Alves C, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Simões M
 PMID: 12891537.
p63 expression in solid cell nests of the thyroid: further evidence for a stem cell origin. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 16: 43-8, 2003. [Article] 
69. Rocha AS, Soares P, Fonseca E, Cameselle-Teijeiro J, Oliveira MC, Sobrinho-Simões M
 PMID: 12786894.
Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis. International journal of surgical pathology 11: 1-9, 2003. [Article] 
 PMID: 12598910.
Germline succinate dehydrogenase subunit D mutation segregating with familial non-RET C cell hyperplasia. The Journal of clinical endocrinology and metabolism 88: 4932-7, 2003. [Article] 
 PMID: 14557476.
72. Cameselle-Teijeiro J, Manuel Lopes J, Villanueva JP, Gil-Gil P, Sobrinho-Simões M
 PMID: 14511266.
Alterations of the SDHD gene locus in midgut carcinoids. Genes, chromosomes & cancer 36: 424, 2003. [Letter] 
 doi: 10.1002/gcc.10147 PMID: 12619155.
74. Lima J, Máximo V, Soares P, Williams D, Bogdanova T, Thomas GA, Sobrinho-Simões M
75. Carneiro F, Machado JC, Nabais S, Santos CM, Sobrinho Simões M
Mixed carcinoma of the stomach: a clinicopathological entity. Histopathology 43: 94-5, 2003. [Letter] 
 PMID: 12823718.
76. Cameselle-Teijeiro J, Sobrinho-Simões M
Carcinoma papilar de la glândula tireoide. Problemas en el diagnostico y controversias. Revista Española de Patologia 36: 373-382, 2003. [] 
Vascular invasion in thyroid and gastric carcinomas. Ultrastructural pathology 27: 41-8, 2003. [Article; Proceedings Paper] 
 PMID: 12554535.
 PMID: 15357248.
79. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-Simões M
 PMID: 12441323.
80. Máximo V, Soares P, Lima J, Cameselle-Teijeiro J, Sobrinho-Simões M
 PMID: 12000737.
82. Silva E, Teixeira A, David L, Carneiro F, Reis CA, Sobrinho-Simões J, Serpa J, Veerman E, Bolscher J, Sobrinho-Simões M
Mucins as key molecules for the classification of intestinal metaplasia of the stomach. Virchows Archiv : an international journal of pathology 440: 311-7, 2002. [Article] 
83. Teixeira A, David L, Reis CA, Costa J, Sobrinho-Simões M
 doi: 10.1002/path.1083 PMID: 12081201.
Follicular, papillary, and "hybrid" carcinomas of the thyroid. Endocrine pathology 13: 313-20, 2002. [Article] 
 PMID: 12665649.
85. Rocha AS, Soares P, Machado JC, Máximo V, Fonseca E, Franssila K, Sobrinho-Simões M
 PMID: 12383223.
Difficult cases of thyroid pathology. Endocrine pathology 13: 369-70; author reply 371, 2002. [Letter] 
 PMID: 12665655.
88. Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Simões M
 PMID: 11606496.
89. Machado JC, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, Seruca R, Carneiro F, Sobrinho-Simöes M
 PMID: 11550281.
91. Rocha AS, Soares P, Seruca R, Máximo V, Matias-Guiu X, Cameselle-Teijeiro J, Sobrinho-Simões M
 doi: 10.1002/path.905 PMID: 11439369.
92. Cameselle-Teijeiro J, Ruiz-Ponte C, Loidi L, Suarez-Peñaranda J, Baltar J, Sobrinho-Simoes M
Fetal adenomas and minimally invasive follicular carcinomas of the thyroid frequently display a triploid or near triploid DNA pattern. Virchows Archiv : an international journal of pathology 438: 336-42, 2001. [Article] 
 PMID: 11355166.
94. Williams ED, Sobrinho-Simoes M
Surgical pathology versus molecular biology. International journal of surgical pathology 9: 1-3, 2001. [Editorial Material] 
 PMID: 11469340.
Current thoughts on the histopathogenesis of gastric cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 10: 101-2, 2001. [Article; Proceedings Paper] 
 PMID: 11263582.
96. Nabais S, Carneiro F, Nogueira AM, Machado JC, Seruca R, Sobrinho-Simões M
 doi: 10.1002/path.958 PMID: 11745702.
Tumours of the thyroid gland. UICC Comprehensive Tumour Terminology Handbook 1: 23-32, 2001. [] 
Tumours of the parathyroid gland. UICC Comprehensive Tumour Terminology Handbook 1: 33-35, 2001. [] 
99. Nogueira AM, Carneiro F, Sobrinho-Simões M
Early gastric stump carcinoma with rhabdoid features. Pathology, research and practice 197: 93-4, 2001. [Letter] 
 PMID: 11261823.
100. Reis CA, David L, Carvalho F, Mandel U, de Bolós C, Mirgorodskaya E, Clausen H, Sobrinho-Simões M
Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 48: 377-88, 2000. [Article] 
 PMID: 10681391.
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