RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH
 
Fátima Gärtner
Name: Fátima Gärtner
E-mail: fgartner@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


Fátima Gärtner
Fátima Gärtner
Member of
Director of Animal Model Facility
Researcher of Glycobiology in Cancer


Short CV
Maria de Fátima Moutinho Gärtner is graduated in Veterinary Medicine in the Faculty of Veterinary Medicine of Nova Lisboa, University of Luanda in 1975. She did her Ph.D. Degree in Pathology in the Medical Faculty of the University of Cape Town, Republic of South Africa in 1986. She was junior researcher at Ipatimup and Faculty of Medicine, University of Porto between 1991 and 1995. She is currently a senior researcher at the Ipatimup. Fátima Gärtner is a specialist in Anatomic Pathology and a member of the European College of Veterinary Pathology (ECVP) and oncobiology with emphasis for canine and feline mammary tumours. She is a Full Professor of Pathology at the Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP) since 2006, Vice Chairman of the Scientific Council of ICBAS-UP since 2002 and director of the Department of Pathology and Molecular Immunology ICBAS-UP. Started in 1991, the in vivo research unit , Ipatimup Animal House, with a colony of athymic nude mice and has since took the supervision of the research underway in this unit. Since 2009 is director of the doctoral program of Veterinary Sciences and director of the doctoral program of Pathology and Molecular Genetics at ICBAS-UP, since 2011. She supervised several PhD and master students of Porto University as well as other portuguese and foreignuniversities. Has collaboration, in the research field as well as in teaching, with several foreign universities, particularly the University of Bologna, Italy, University of São Paulo (UESP), University of Minas Gerais (UFMG) and UNESP, Brazil. She is author and/or co-author of more than 100 articles published in indexed international journals. She is the author of a book of national circulation and wrote several chapters in books of international circulation.

Highlights
Our research work will focus on the dynamic interplay between galectins and their binding sites in a spontaneous model of canine mammary tumour progression and invasion. Thus we have a few lines of ongoing research such as:
A project funded by FCT and with title: ""The role of sialylation in modulating galectin-3 functions in the metastatic process"" which will involve a series of tasks such as:
1. Assessment of the involvement of down-regulation of sialyltransferases and a possible galectin-3 recognition of sialylated TAA in increased galectin-3-binding sites expression in invading cells of CMMT.
2. Study of the expression and activity of sialidases in CMMT and their possible modulatory role of galectin-3 functions in CMMT
3. Evaluation of the effects of the treatment of CMMT xenografted in nude mice with the sialidase inhibitor Tamiflu

Supervisor of
Ana Flores, PhD Student
Francisco Cortez Nunes, PhD Student
Nuno Mendes, Research Technician
Patrícia Barradas, PhD Student
Patrícia Moreira, Animal Handlers
Rita Matos, PhD Student
Sílvia Teixeira, PhD Student

PI (running)

PI (closed)
The role of sialylation in modulating galectin-3 functions in the metastatic process
TAF - Termoterapia Altamente Focalizada de tumores sólidos usando um cimento ferrimagnético injectável
In vitro and in vivo manipulation of the expression of Sialyl Lewis X and E-cadherin in canine malignant mammary
Biological characterization of canine mammary mixed tumours: histogenesis, tumour progression and genetic alterations
Cat mammary tumors-Pathologic, Molecular and Cytogenetic approaches
First Author
 
C
IF
1. Gärtner F, Santos M, Gillette D, Schmitt F
Inflammatory pseudotumour of the spleen in a dog. The Veterinary record 150: 697-8, 2002. [Article] 
 PMID: 12074242.
 
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1.2
2. Gärtner F, Geraldes M, Cassali G, Rema A, Schmitt F
DNA measurement and immunohistochemical characterization of epithelial and mesenchymal cells in canine mixed mammary tumours: putative evidence for a common histogenesis. Veterinary journal (London, England : 1997) 158: 39-47, 1999. [Review] 
 doi: 10.1053/tvjl.1998.0333 PMID: 10409415.
 
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1.3
3. Gärtner F, David L, Seruca R, Machado JC, Sobrinho-Simões M
Establishment and characterization of two cell lines derived from human diffuse gastric carcinomas xenografted in nude mice. Virchows Archiv : an international journal of pathology 428: 91-8, 1996. [Article] 
 PMID: 8925130.
 
31
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Senior Author
 
C
IF
1. Flores AR, Lobo J, Nunes F, Rêma A, Lopes P, Carvalho L, Bartosch C, Amorim I, Gärtner F
Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review. Journal of ovarian research 12: 89, 2019. [Review] 
 doi: 10.1186/s13048-019-0561-x PMID: 31547830.
 
0
2.5 (*)
2. Amorim I, Taulescu MA, Day MJ, Catoi C, Reis CA, Carneiro F, Gärtner F
Canine Gastric Pathology: A Review. Journal of comparative pathology 154: 9-37, 2016. [Review] 
 doi: 10.1016/j.jcpa.2015.10.181 PMID: 26774560.
 
1
1.2
3. Figueira A.C., Gomes C., Mendes N., Amorim I., de Matos A.J.F., Dias-Pereira P., Gärtner F.
An in vitro and in vivo characterization of the cadherin-catenin adhesion complex in a feline mammary carcinoma cell line Clinical and Diagnostic Pathology 1: 8-8, 2016. [] 
 doi: 10.15761/NRD.1000103.
 
0
0.8 (*)
4. de Oliveira JT, Ribeiro C, Barros R, Gomes C, de Matos AJ, Reis CA, Rutteman GR, Gärtner F
Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis. PloS one 10: e0134458, 2015. [Article] 
 doi: 10.1371/journal.pone.0134458 PMID: 26222311.
 
12
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5. Amorim I, Smet A, Alves O, Teixeira S, Saraiva AL, Taulescu M, Reis C, Haesebrouck F, Gärtner F
Presence and significance of Helicobacter spp. in the gastric mucosa of Portuguese dogs. Gut pathogens 7: 12, 2015. [Article] 
 doi: 10.1186/s13099-015-0057-1 PMID: 25897328.
 
11
2.8
6. de Oliveira JT, Santos AL, Gomes C, Barros R, Ribeiro C, Mendes N, de Matos AJ, Vasconcelos MH, Oliveira MJ, Reis CA, Gärtner F
Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness. PloS one 10: e0121590, 2015. [Article] 
 doi: 10.1371/journal.pone.0121590 PMID: 25850034.
 
2
3.1
7. Figueira AC, Gomes C, Vilhena H, Miranda S, Carvalheira J, DE Matos AJ, Dias-Pereira P, Gärtner F
Characterization of a-, ß- and p120-Catenin Expression in Feline Mammary Tissues and their Relation with E- and P-Cadherin. Anticancer research 35: 3361-9, 2015. [Article] 
 PMID: 26026096.
 
0
1.9
8. Flores AR, Rêma A, Amorim I, Gartner F
Altered Expression of Claudin-1 Is Related With Malignancy in Canine Thyroid Tumors. In vivo (Athens, Greece) 29: 23-28, 2015. [Article] 
 PMID: 25600525.
 
0
0.8
9. Benazzi C, Al-Dissi A, Chau CH, Figg WD, Sarli G, de Oliveira JT, Gärtner F
Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology. TheScientificWorldJournal 2014: 919570, 2014. [Review] 
 doi: 10.1155/2014/919570 PMID: 24563633.
 
21
0.0
10. Amorim I, Freitas DP, Magalhães A, Faria F, Lopes C, Faustino AM, Smet A, Haesebrouck F, Reis CA, Gärtner F
A comparison of Helicobacter pylori and non-Helicobacter pylori Helicobacter spp. Binding to Canine Gastric Mucosa with Defined Gastric Glycophenotype. Helicobacter 19: 249-59, 2014. [Article] 
 doi: 10.1111/hel.12125 PMID: 24689986.
 
9
4.1
11. Amorim I, Taulescu MA, Ferreira A, Rêma A, Reis CA, Faustino AM, Catoi C, Gärtner F
An immunohistochemical study of canine spontaneous gastric polyps. Diagnostic pathology 9: 166, 2014. [Article] 
 doi: 10.1186/s13000-014-0166-z PMID: 25230726.
 
5
2.6
12. DE Oliveira JT, DE Matos AJ, Barros R, Ribeiro C, Chen A, Hespanhol V, Rutteman GR, Gärtner F
Differential expression of galectin-1 and galectin-3 in canine non-malignant and malignant mammary tissues and in progression to metastases in mammary tumors. Anticancer research 34: 2211-21, 2014. [Article] 
 PMID: 24778023.
 
3
1.8
13. Figueira AC, Gomes C, de Oliveira JT, Vilhena H, Carvalheira J, de Matos AJ, Pereira PD, Gärtner F
Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas. BMC veterinary research 10: 270, 2014. [Article] 
 doi: 10.1186/s12917-014-0270-z PMID: 25424750.
 
3
1.8
14. Pinho SS, Carvalho S, Cabral J, Reis CA, Gärtner F
Canine tumors: a spontaneous animal model of human carcinogenesis. Translational research : the journal of laboratory and clinical medicine 159: 165-72, 2012. [Review] 
 doi: 10.1016/j.trsl.2011.11.005 PMID: 22340765.
 
100
3.5
15. Tavares C, de Oliveira JT, Lopes C, Carvalheira J, Matos AJ, Rutteman G, Reis CA, Gärtner F
Mucin 6 and tn antigen expression in canine mammary tumours: correlation with pathological features. Journal of comparative pathology 147: 410-8, 2012. [Article] 
 doi: 10.1016/j.jcpa.2012.03.007 PMID: 22595635.
 
3
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16. Figueira AC, Teodósio AS, Carvalheira J, Lacerda M, de Matos A, Gärtner F
P-cadherin expression in feline mammary tissues. Veterinary medicine international 2012: 10.1155/2012/687424, 2012. [] 
 doi: 10.1155/2012/687424 PMID: 23091776.
 
0
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17. Gil da Costa RM, Rema A, Pires MA, Gärtner F
Two canine Merkel cell tumours: immunoexpression of c-KIT, E-cadherin, beta-catenin and S100 protein. Veterinary dermatology 21: 198-201, 2010. [Article] 
 doi: 10.1111/j.1365-3164.2009.00768.x PMID: 19706008.
 
10
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18. de Oliveira JT, Pinho SS, de Matos AJ, Hespanhol V, Reis CA, Gärtner F
MUC1 expression in canine malignant mammary tumours and relationship to clinicopathological features. Veterinary journal (London, England : 1997) 182: 491-3, 2009. [Article] 
 doi: 10.1016/j.tvjl.2008.09.007 PMID: 18948041.
 
13
2.3
19. Amorim IF, Faria F, Lopes C, Reis C, Faustino A, Gartner F
Helicobacter Infection in Cats of the North of Portugal Preliminary Results Helicobacter 14: 353-353, 2009. [Meeting Abstract] 
.
 
0
2.9
20. Pinho SS, Matos AJ, Lopes C, Marcos NT, Carvalheira J, Reis CA, Gärtner F
Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression. BMC cancer 7: 124, 2007. [Article] 
 doi: 10.1186/1471-2407-7-124 PMID: 17617904.
 
30
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21. Gil da Costa RM, Rema A, Payo-Puente P, Gärtner F
Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus). Journal of comparative pathology 137: 130-2, 2007. [Article] 
 doi: 10.1016/j.jcpa.2006.04.006 PMID: 17645891.
 
5
1.5
22. Matos AJ, Duarte S, Lopes C, Lopes JM, Gärtner F
Splenic hamartomas in a dog. The Veterinary record 161: 308-10, 2007. [Article] 
 PMID: 17766811.
 
4
1.1
23. Gil da Costa RM, Matos E, Rema A, Lopes C, Pires MA, Gärtner F
CD117 immunoexpression in canine mast cell tumours: correlations with pathological variables and proliferation markers. BMC veterinary research 3: 19, 2007. [] 
 doi: 10.1186/1746-6148-3-19 PMID: 17711582.
 
0
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24. Matos AJ, Lopes C, Carvalheira J, Santos M, Rutteman GR, Gärtner F
E-cadherin expression in canine malignant mammary tumours: relationship to other clinico-pathological variables. Journal of comparative pathology 134: 182-9, 2006. [Article] 
 doi: 10.1016/j.jcpa.2005.10.004 PMID: 16545841.
 
40
0.9
25. Matos AJ, Faustino AM, Lopes C, Rutteman GR, Gärtner F
Detection of lymph node micrometastases in malignant mammary tumours in dogs by cytokeratin immunostaining. The Veterinary record 158: 626-30, 2006. [Article] 
 PMID: 16679481.
 
23
1.2
26. De Matos AJ, Lopes CC, Faustino AM, Carvalheira JG, Dos Santos MS, Rutteman GR, Gärtner Mde F
MIB-1 labelling indices according to clinico-pathological variables in canine mammary tumours: a multivariate study. Anticancer research 26: 1821-6, 2006. [Article] 
 PMID: 16827113.
 
22
1.5
27. Dias Pereira P, Carvalheira J, Gärtner F
Cell proliferation in feline normal, hyperplastic and neoplastic mammary tissue--an immunohistochemical study. Veterinary journal (London, England : 1997) 168: 180-5, 2004. [Article] 
 doi: 10.1016/j.tvjl.2003.10.018 PMID: 15301767.
 
20
1.2
28. Reis AL, Carvalheira J, Schmitt FC, Gärtner F
Immunohistochemical study of the expression of E-cadherin in canine mammary tumours. The Veterinary record 152: 621-4, 2003. [Article] 
 PMID: 12790166.
 
23
1.2
29. Dias Pereira P, Gärtner F
Expression of E-cadherin in normal, hyperplastic and neoplastic feline mammary tissue. The Veterinary record 153: 297-302, 2003. [Article] 
 PMID: 14509576.
 
12
1.2
30. Reis-Filho JS, Gonçalves C, Gärtner F
Rectal leiomyosarcoma in a dog and review of gastrointestinal stromal tumours. The Veterinary record 153: 215-7, 2003. [Article] 
 PMID: 12956300.
 
4
1.2
31. Dias Pereira P, Azevedo M, Gärtner F
Case of malignant biphasic mesothelioma in a dog. The Veterinary record 149: 680-1, 2001. [Article] 
 PMID: 11765328.
 
4
1.1
32. Brown PJ, Rêma A, Gartner F
Thyroglobulin, calcitonin, Ki-67 and CEA immunohistochemical staining of dog thyroid carcinomas. European Journal of  Veterinary Pathology 7: 11-16, 2001. [] 
.
 
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@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
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