Celso Reis
Name: Celso Reis
E-mail: celsor@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


Celso Reis
Celso Reis
Member of
Coordinator Researcher of Glycobiology in Cancer
Coordinator Researcher of Proteomics


Short CV
Celso A. Reis is the Head of the Glycobiology in Cancer group at i3S/Ipatimup, University of Porto, where he leads an international multidisciplinary team working on the Glycobiology in human diseases with focus on Cancer. He has published 186 peer-reviewed papers, with over 10100 citations and with H-index of 48 (Scopus). His publications include papers in journals such as: Cancer Cell, Nature Cell Biology, Glycobiology, Glycoconjugate Journal, International Journal of Cancer, Cancer Research, PNAS, JBC, JACS, BBA, FEBS Lett, Molecular Cellular Proteomics, Journal of Proteomics Oncogene, Cancer Letters, Mucosal Immunology, Cellular Immunology, Journal Clinical Investigation, Nature Reviews in Cancer, among others.

Celso A. Reis research focus on the role of glycosylation in human cancer. He has addressed the molecular mechanisms controlling glycosylation in cancer cell biology, more specifically the role of glycosyltransferases regulating the biosynthesis of glycans in cancer. These included the role of sialyltransferases leading to the biosynthesis of terminal sialylated glycan antigens expressed by cancer cells, such as ST6GalNAc determining the aberrant expression of the simple O-glycan Sialyl-Tn antigen, and the ST3Gal-transferases and Fucosyltransferases controlling the expression of sialyl-Lewis antigens.

Celso A. Reis has contributed for determining the role of these glycosylation modifications, including O-glycans and N-Glycans and the consequences to gastrointestinal cancer cell biology, including the mechanisms regulating cancer invasion, metastasis and tumour glycoimmunology. CR has also addressed the application of glycoconjugates as biomarkers in human cancer and pre-neoplastic lesions, and the application of novel unique monoclonal antibodies to clinical samples, currently in the market.

Currently, Celso A. Reis develops novel strategies to detect and characterize cancer, in order to be able to improve cancer treatment based on the identification of the key glycans controlling cancer cell communication, glycans that can be used as markers for cancer patient stratification, as well as glycans and glycoconjugate that can be used as novel targets in therapy.

Highlights
Celso A. Reis has published 186 peer-reviewed papers, with over 10100 citations and with H-index of 48 (Scopus). His publications include papers in journals such as: Cancer Cell, Nature Cell Biology, Glycobiology, Glycoconjugate Journal, International Journal of Cancer, Cancer Research, PNAS, JBC, JACS, BBA, FEBS Lett, Molecular Cellular Proteomics, Journal of Proteomics Oncogene, Cancer Letters, Mucosal Immunology, Cellular Immunology, Journal Clinical Investigation, Nature Reviews in Cancer, among others. He has contributed with various patents and novel unique monoclonal antibodies targeting glycoproteins that are currently in the market for application in clinical samples.

Supervisor of
Álvaro Martins, Young Researcher (Msc)
Ana Magalhães, Junior Researcher
António Polónia, Researcher
Beatriz Leão, Visiting Researcher
Catarina Gomes, Junior Researcher
Daniela Freitas, Junior Researcher
Filipe Pinto, Post Doc
Francisca Diniz, PhD Student
Irina Amorim, Researcher
Isabel Mesquita, Visiting Researcher
Joana Rodrigues, PhD Student
Lucia Sanjurjo, Visiting Researcher

PI (running)

PI (closed)
First Author
 
C
IF
1. Reis C
Cellular glycosylation: biosynthesis and functional implications in cancer Febs Open Bio 9: 60-61, 2019. [Meeting Abstract] 
.
 
2. Madeira PP, Reis CA, Rodrigues AE, Mikheeva LM, Chait A, Zaslavsky BY
Solvent properties governing protein partitioning in polymer/polymer aqueous two-phase systems. Journal of chromatography. A 1218: 1379-84, 2011. [Article] 
 
3. Reis CA, Campos D, Osório H, Santos LL
Glycopeptide microarray for autoantibody detection in cancer. Expert review of proteomics 8: 435-7, 2011. [Review] 
 doi: 10.1586/epr.11.30 PMID: 21819298.
 
Alterations in glycosylation as biomarkers for cancer detection. Journal of clinical pathology 63: 322-9, 2010. [Review] 
 
5. Reis C, Lopes JM, Carneiro E, Vilarinho A, Portugal R, Duarte F, Fonseca J
Temporal giant cell reparative granuloma: a reappraisal of pathology and imaging features. AJNR. American journal of neuroradiology 27: 1660-2, 2006. [Article] 
 PMID: 16971609.
 
6. Reis CA, Teixeira A, David L
Role of mucins in Helicobacter pylori adhesion to the gastric mucosa. Helicobacter 9: 181; author reply 181-2, 2004. [Letter] 
 
7. Reis CA, David L, Carvalho F, Mandel U, de Bolós C, Mirgorodskaya E, Clausen H, Sobrinho-Simões M
Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 48: 377-88, 2000. [Article] 
 PMID: 10681391.
 
8. Reis CA, David L, Correa P, Carneiro F, de Bolós C, Garcia E, Mandel U, Clausen H, Sobrinho-Simões M
 PMID: 10070955.
 
9. Reis CA, David L, Seixas M, Burchell J, Sobrinho-Simões M
Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma. International journal of cancer 79: 402-10, 1998. [Article] 
 PMID: 9699534.
 
10. Reis CA, Sørensen T, Mandel U, David L, Mirgorodskaya E, Roepstorff P, Kihlberg J, Hansen JE, Clausen H
 PMID: 9530956.
 
11. Reis CA, Hassan H, Bennett EP, Clausen H
Characterization of a panel of monoclonal antibodies using GalNAc glycosylated peptides and recombinant MUC1. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 19 Suppl 1: 127-33, 1998. [Article; Proceedings Paper] 
 PMID: 9422098.
 
12. Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, Sobrinho-Simões M
 PMID: 9036879.
 
Senior Author
 
C
IF
1. Mereiter S, Balmaña M, Campos D, Gomes J, Reis CA
 
2. Mereiter S, Martins ÁM, Gomes C, Balmaña M, Macedo JA, Polom K, Roviello F, Magalhães A, Reis CA
O-glycan truncation enhances cancer-related functions of CD44 in gastric cancer. FEBS letters 593: 1675-1689, 2019. [Article; Proceedings Paper] 
 
3. Freitas D, Balmaña M, Poças J, Campos D, Osório H, Konstantinidi A, Vakhrushev SY, Magalhães A, Reis CA
Different isolation approaches lead to diverse glycosylated extracellular vesicle populations. Journal of extracellular vesicles 8: 1621131, 2019. [Article] 
 
 
5. Reis C
Cellular glycosylation: biosynthesis and functional implications in cancer Febs Open Bio 9: 60-61, 2019. [Meeting Abstract] 
.
 
6. Gomes C, Almeida A, Barreira A, Calheiros J, Pinto F, Abrantes R, Costa A, Polonia A, Campos D, Osório H, Sousa H, Pinto-de-Sousa J, Kolarich D, Reis CA
 doi: 10.7150/thno.33858 PMID: 31695778.
 
Gastric cancer: Basic aspects. Helicobacter 23 Suppl 1: e12523, 2018. [Article; Proceedings Paper] 
 doi: 10.1111/hel.12523 PMID: 30277636.
 
8. Mereiter S, Polom K, Williams C, Polonia A, Guergova-Kuras M, Karlsson NG, Roviello F, Magalhães A, Reis CA
 doi: 10.3390/jcm7090256 PMID: 30189652.
 
9. Balmaña M, Mereiter S, Diniz F, Feijão T, Barrias CC, Reis CA
 
Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer cell 31: 733-735, 2017. [Editorial Material] 
 
11. Ferreira JA, Magalhães A, Gomes J, Peixoto A, Gaiteiro C, Fernandes E, Santos LL, Reis CA
 
12. Duarte HO, Balmaña M, Mereiter S, Osório H, Gomes J, Reis CA
Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor. International journal of molecular sciences 18: ., 2017. [Article] 
 
13. Gomes J, Mereiter S, Magalhães A, Reis CA
Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries. Cancer cell 32: 544-545, 2017. [Editorial Material] 
 
14. Mereiter S, Balmaña M, Gomes J, Magalhães A, Reis CA
Glycomic Approaches for the Discovery of Targets in Gastrointestinal Cancer. Frontiers in oncology 6: 55, 2016. [Review] 
 
15. Mereiter S, Magalhães A, Adamczyk B, Jin C, Almeida A, Drici L, Ibáñez-Vea M, Gomes C, Ferreira JA, Afonso LP, Santos LL, Larsen MR, Kolarich D, Karlsson NG, Reis CA
 
16. Magalhães A, Rossez Y, Robbe-Masselot C, Maes E, Gomes J, Shevtsova A, Bugaytsova J, Borén T, Reis CA
 doi: 10.1038/srep25575 PMID: 27161092.
 
Mucin-Type O-Glycosylation in Gastric Carcinogenesis. Biomolecules 6: 1, 2016. [Review] 
 doi: 10.3390/biom6030033 PMID: 27409642.
 
18. Mereiter S, Magalhães A, Adamczyk B, Jin C, Almeida A, Drici L, Ibáñez-Vea M, Larsen MR, Kolarich D, Karlsson NG, Reis CA
Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4. Data in brief 7: 814-33, 2016. [Article; Data Paper] 
 
19. Magalhães A, Mereiter S, Reis C
 
Glycosylation in cancer: mechanisms and clinical implications. Nature reviews. Cancer 15: 540-55, 2015. [Review] 
 doi: 10.1038/nrc3982 PMID: 26289314.
 
21. Campos D, Freitas D, Gomes J, Magalhães A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA
Probing the o-glycoproteome of gastric cancer cell lines for biomarker discovery. Molecular & cellular proteomics : MCP 14: 1616-29, 2015. [Article] 
 
22. Magalhães A, Marcos-Pinto R, Nairn AV, Dela Rosa M, Ferreira RM, Junqueira-Neto S, Freitas D, Gomes J, Oliveira P, Santos MR, Marcos NT, Xiaogang W, Figueiredo C, Oliveira C, Dinis-Ribeiro M, Carneiro F, Moremen KW, David L, Reis CA
Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852: 1928-39, 2015. [Article] 
 
 
24. Pinho SS, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhães A, Gärtner F, Mendonfa AM, Isaji T, Gu J, Carneiro F, Seruca R, Taniguchi N, Reis CA
 PMID: 23671930.
 
25. Pinho SS, Carvalho S, Marcos-Pinto R, Magalhães A, Oliveira C, Gu J, Dinis-Ribeiro M, Carneiro F, Seruca R, Reis CA
Gastric cancer: adding glycosylation to the equation. Trends in molecular medicine 19: 664-76, 2013. [Review] 
 
26. Gomes C, Osório H, Pinto MT, Campos D, Oliveira MJ, Reis CA
 
Immunodetection of glycosyltransferases in gastrointestinal tissues. Methods in molecular biology (Clifton, N.J.) 1022: 349-56, 2013. [] 
 
Mass spectrometry methods for studying glycosylation in cancer. Methods in molecular biology (Clifton, N.J.) 1007: 301-16, 2013. [] 
 
29. Gomes J, Magalhães A, Carvalho AS, Hernandez GE, Papp SL, Head SR, Michel V, David L, Gärtner F, Touati E, Reis CA
 
30. Pinho SS, Seruca R, Gärtner F, Yamaguchi Y, Gu J, Taniguchi N, Reis CA
Modulation of E-cadherin function and dysfunction by N-glycosylation. Cellular and molecular life sciences : CMLS 68: 1011-20, 2011. [Review] 
 
31. Marcos NT, Bennett EP, Gomes J, Magalhaes A, Gomes C, David L, Dar I, Jeanneau C, Defrees S, Krustrup D, Vogel LK, Kure EH, Burchell J, Taylor-Papadimitriou J, Clausen H, Mandel U, Reis CA
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues. Frontiers in bioscience (Elite edition) 3: 1443-55, 2011. [] 
 PMID: 21622148.
 
32. Carvalho AS, Harduin-Lepers A, Magalhães A, Machado E, Mendes N, Costa LT, Matthiesen R, Almeida R, Costa J, Reis CA
 
Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 43: 611-8, 2010. [Review] 
 PMID: 20521012.
 
34. Magalhães A, Ismail MN, Reis CA
Sweet receptors mediate the adhesion of the gastric pathogen Helicobacter pylori: glycoproteomic strategies. Expert review of proteomics 7: 307-10, 2010. [Editorial Material] 
 doi: 10.1586/epr.10.18 PMID: 20536299.
 
35. Magalhães A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osório H, David L, Le Pendu J, Haas R, Dell A, Borén T, Reis CA
 
36. Pinho SS, Osório H, Nita-Lazar M, Gomes J, Lopes C, Gärtner F, Reis CA
Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochemical and biophysical research communications 379: 1091-6, 2009. [Article] 
 
37. Gomes J, Marcos NT, Berois N, Osinaga E, Magalhães A, Pinto-de-Sousa J, Almeida R, Gärtner F, Reis CA
Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 57: 79-86, 2009. [Article] 
 
38. Magalhães A, Marcos N T, Carvalho A S, David L, Figueiredo C, Bastos J, David G, Reis C
 
39. Gomes J, Michel V, Magalhaes A, Ovesen RG, Hansen HH, Gartner F, Touati E, Reis CA
.
 
40. Marcos NT, Magalhães A, Ferreira B, Oliveira MJ, Carvalho AS, Mendes N, Gilmartin T, Head SR, Figueiredo C, David L, Santos-Silva F, Reis CA
 doi: 10.1172/JCI34324 PMID: 18483624.
 
41. Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA
 
42. Ferreira B, Marcos NT, David L, Nakayama J, Reis CA
Terminal alpha1,4-linked N-acetylglucosamine in Helicobacter pylori-associated intestinal metaplasia of the human stomach and gastric carcinoma cell lines. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 54: 585-91, 2006. [Article] 
 
43. Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA
 
44. Marcos NT, Cruz A, Silva F, Almeida R, David L, Mandel U, Clausen H, Von Mensdorff-Pouilly S, Reis CA
Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 51: 761-71, 2003. [Article] 
 PMID: 12754287.
 
45. Schmitt FC, Pereira MB, Reis CA
MUC 5 expression in breast carcinomas. Human pathology 30: 1270-1, 1999. [Letter] 
 PMID: 10534181.
 
46. Price MR, Rye PD, Petrakou E, Murray A, Brady K, Imai S, Haga S, Kiyozuka Y, Schol D, Meulenbroek MF, Snijdewint FG, von Mensdorff-Pouilly S, Verstraeten RA, Kenemans P, Blockzjil A, Nilsson K, Nilsson O, Reddish M, Suresh MR, Koganty RR, Fortier S, Baronic L, Berg A, Longenecker MB, Hilgers J, Reis CA
Summary report on the ISOBM TD-4 Workshop: analysis of 56 monoclonal antibodies against the MUC1 mucin. San Diego, Calif., November 17-23, 1996. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 19 Suppl 1: 1-20, 1998. [Article; Proceedings Paper] 
 PMID: 9422084.
 
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