Nuno Santos
Name: Nuno Santos
Academic Degree: PhD

Nuno Santos
Nuno Santos
Member of

Short CV

Research Fellow (Investigador Auxiliar) and Team Leader in Molecular Biology of Leukemia at i3S since 2016.

He obtained his PhD degree at the Radboud University Nijmegen (NL), under supervision of Prof. Ad Geurts van Kessel, and perfomed post-doctoral research at the Jacques Ghysdael group in Institut Curie (Orsay, FR). He became an independent researcher in 2008, when establishing a research group at the Centre for Biomedical Research of the University of Algarve (Faro, PT).

The main objectives of his reserch team are to uncover the molecular and cellular mechanisms of acute lymphoblastic leukemia and identify potential therapeutic targets. 

Over the years, he has investigated the role of T-cell receptor signaling in T-cell leukemia (Blood 2007; Cancer Discovery 2016) and his group is investigating TCR mechanisms to prevent disease dissemination or to kill leukemic cells. He has also uncovered a role for microenvironmental cells in assisting T-cell leukemia development (PLoS One 2008; Br J Haematol 2015; Carcinogenesis 2018) and his group is investigating the role of lymphotoxin signaling in microenvironmental cells.



Supervisor of
Ivette Pacheco, Junior Researcher
Junior Researcher
Marina Baessa, PhD Student
PhD student
Mário Pimenta, PhD Student
PhD student
Telma Costa, PhD Student
PhD student

PI (running)

PI (closed)
First Author
Senior Author
1. Pereira JL, Cavaco P, da Silva RC, Pacheco-Leyva I, Mereiter S, Pinto R, Reis CA, Dos Santos NR
2. Fernandes MT, Caroço LS, Pacheco-Leyva I, Dos Santos NR
NF-¿B-dependent RANKL expression in a mouse model of immature T-cell leukemia. Biochemical and biophysical research communications 510: 272-277, 2019. [Article] 
3. Ghezzo MN, Fernandes MT, Pacheco-Leyva I, Rodrigues PM, Machado RS, Araújo MAS, Kalathur RK, Futschik ME, Alves NL, Dos Santos NR
FoxN1-dependent thymic epithelial cells promote T-cell leukemia development. Carcinogenesis 39: 1463-1476, 2018. [Article] 
4. Fernandes MT, Dejardin E, Dos Santos NR
Context-dependent roles for lymphotoxin-ß receptor signaling in cancer development. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1865: 204-19, 2016. [Review] 
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