Joana Figueiredo
Name: Joana Figueiredo
Academic Degree: PhD

Joana Figueiredo
Joana Figueiredo
Member of

Short CV

Joana Figueiredo graduated in Applied Biology in 2005 at University of Minho. During her training program at IPATIMUP, she became fascinated by cancer biology. Joana Figueiredo got her first research fellowship to study the effects of oncogene activation during carcinogenesis, and one year later, she started a new project addressing the dynamics of cell-cell adhesion in gastric cancer. Joana Figueiredo completed her PhD in 2012 at the Medical School of University of Porto, under the supervision of Professor Raquel Seruca. 

Currently, Joana Figueiredo is an Assistant Researcher at the Intercellular Communication and Cancer Group, investigating the molecular mechanisms underlying distinct clinical spectra of E-cadherin mutations. Her research focuses on the crosstalk between cell-cell and cell-matrix interactions in pathological conditions. In particular, she is interested in how this crosstalk impacts cancer cell invasion. Joana Figueiredo has established an international collaborative network with clinicians and genetic counselors worldwide, aiming to define the significance of genetic variants and to establish accurate patient management protocols.

The main research domain of Joana Figueiredo is cell biology with particular emphasis on E-cadherin post-translational regulation, trafficking and signalling.
She is also interested in the study of cell-cell and cell-extracellular matrix interactions dependent on E-cadherin.
Currently, she uses as a model the Hereditary Diffuse Gastric Cancer, as this cancer syndrome is a highly invasive disease and is caused by E-cadherin germline defects, that result in E-cadherin loss of function.

Supervisor of
Luísa Carvalho, PhD Student
PhD student
José Santos, Master Student (theoretical phase)
MSc student

PI (running)

PI (closed)
First Author
1. Figueiredo J, Ferreira RM, Xu H, Gonçalves M, Barros-Carvalho A, Cravo J, Maia AF, Carneiro P, Figueiredo C, Smith ML, Stamenovic D, Morais-de-Sá E, Seruca R
Integrin ß1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 25: 124-137, 2022. [Article] 
2. Figueiredo J, Mercadillo F, Melo S, Barroso A, Gonçalves M, Díaz-Tasende J, Carneiro P, Robles L, Colina F, Ibarrola C, Perea J, Morais-de-Sá E, Seruca R, Urioste M
3. Figueiredo J, Melo S, Carneiro P, Moreira AM, Fernandes MS, Ribeiro AS, Guilford P, Paredes J, Seruca R
Clinical spectrum and pleiotropic nature of CDH1 germline mutations. Journal of medical genetics 56: 199-208, 2019. [Review] 
4. Figueiredo J, Melo S, Gamet K, Godwin T, Seixas S, Sanches JM, Guilford P, Seruca R
5. Figueiredo J, Rodrigues I, Ribeiro J, Fernandes MS, Melo S, Sousa B, Paredes J, Seruca R, Sanches JM
6. Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R
7. Figueiredo J, Simões-Correia J, Söderberg O, Suriano G, Seruca R
Senior Author
1. Corso G, Corso F, Bellerba F, Carneiro P, Seixas S, Cioffi A, La Vecchia C, Magnoni F, Bonanni B, Veronesi P, Gandini S, Figueiredo J
2. Moreira AM, Pereira J, Melo S, Fernandes MS, Carneiro P, Seruca R, Figueiredo J
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