José Carlos Machado
Name: José Carlos Machado
E-mail: josem@ipatimup.pt
Extension: 
225570700
Academic Degree: PhD


José Carlos Machado
José Carlos Machado
Member of
Molecular Genetics Specialist of Ipatimup Diagnostics


Short CV

José C. Machado (JCM) is a Full Professor at the Faculty of Medicine of the University of Porto, Group Leader at i3S and a member of the Executive Committees of i3S and Ipatimup. He studied Biology at the University of Porto and developed his PhD at the Universities of Tubingen, Germany, and Porto, Portugal. JCM is best known for his scientific work on the role of Helicobacter pylori infection and E-cadherin in gastric cancer. He was a member of the scientific committees of UEG (United European Gastroenterology) and ESHG (European Society of Human Genetics). He was awarded the ECP (European Cancer Prevention Organization) Young Researcher Prize 2000, a Scholar-in-training Award for Promising Cancer Research from AACR in 2001, the National Gastroenterology Prize 2005, and the Pfizer Clinical Research Prize 2018. JCM was also the head of the molecular diagnostics laboratory of IPATIMUP. As of May 2024, JCM is a co-author of 200 scientific publications, with a total number of citations over 15000 and an h-index of 50 (Scopus Author ID: 7102792651).


Highlights

Supervisor of
Aina Aina, Research Trainee
Research Trainee
Ana Vilarinho, PhD student
Research Trainee
Bauke Ylstra, Consultant
External Researcher
Other
Others
Carlos Resende, Junior Researcher
Junior Researcher
Cátia Pereira, Research Technician
Gonçalo Vale, Research Technician
Team Member
Helena Ferreira, Research Technician
Temporary
João Pereira, Fellow
PhD Fellowship
Pedro Leite, Research Technician
Team Member
José Costa, Visiting Researcher
Visiting Researcher
José Matos, Bioinformatics technician
Team Member
José Guimarães, PhD Student
PhD student
Luana Pereira, Master Student (theoretical phase)
MSc student
Márcia Baixia, Research Technician
Gabriela Fernandes, Assistant Professor
External Researcher
Maria Quental, Research Technician
Sofia Fernandes, Junior Researcher
Junior Researcher
Marie Dumont, Research Trainee
Research Trainee
Marta Ferreira, Team Member
Young Research Technician
Nuno Santos, Principal Researcher
Researcher
Patrícia Domingues, Research Technician
Team Member
Raquel Lima, Lab Technician
Team Member
Raquel Silva, Young Research Technician
Regina Pinto, Lab Technician
Rui Silva, Quality manager
Rui Simões, Assistant Researcher
Sónia Melo, Principal Researcher
Researcher
Susana Neto, PhD Student
Visiting Researcher
Tânia Pereira, Administrative Assistant

PI (running)

PI (closed)
First Author
 
C
IF
1. Machado JC, Reis J, Fernandes M, Silva R, Cirnes L, Carneiro F, Costa JL
Tumor-specific neoantigens drive T-cell clonotype convergence European journal of cancer (Oxford, England : 1990) 92: S11-S11, 2018. [Meeting Abstract] 
.
 
2. Machado JC, Reis J, Fernandes M, Silva R, Cirnes L, Chaudhary R, Carneiro F, Costa JL
Determining tumor mutation load using an NGS-based, target gene panel European journal of cancer (Oxford, England : 1990) 92: S4-S5, 2018. [Meeting Abstract] 
.
 
3. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Castro Alves C, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Simões M
 PMID: 12891537.
 
.
 
5. Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Simões M
 PMID: 11606496.
 
6. Machado JC, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, Seruca R, Carneiro F, Sobrinho-Simöes M
 
 
E-cadherin mutations in gastric carcinoma. The Journal of pathology 191: 466-8, 2000. [Letter] 
 
Primary signet-ring cell carcinomas of the lung. Human pathology 31: 272, 2000. [Letter] 
 PMID: 10685649.
 
10. Machado JC, Soares P, Carneiro F, Rocha A, Beck S, Blin N, Berx G, Sobrinho-Simões M
E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas. Laboratory investigation; a journal of technical methods and pathology 79: 459-65, 1999. [Article] 
 PMID: 10211998.
 
11. Machado JC, Carneiro F, Ribeiro P, Blin N, Sobrinho-Simões M
pS2 protein expression in gastric carcinoma. An immunohistochemical and immunoradiometric study. European journal of cancer (Oxford, England : 1990) 32A: 1585-90, 1996. [Article] 
 PMID: 8911122.
 
Pattern of pS2 protein expression in premalignant and malignant lesions of gastric mucosa. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 5: 169-79, 1996. [Article] 
 PMID: 8818606.
 
Female sex hormone receptors are not involved in gastric carcinogenesis. A biochemical and immunohistochemical study. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 3 Suppl 2: 31-7, 1994. [Proceedings Paper] 
 PMID: 7735043.
 
Senior Author
 
C
IF
1. R Teixeira M, Oliveira J, Borralho P, O Fernandes MG, Almodovar T, Fernandes I, Macedo D, Ferreira A, Barroso A, Teixeira E, Machado JC
 doi: 10.20344/amp.17680 PMID: 35816050.
 
2. Freitas JA, Gullo I, Garcia D, Miranda S, Spaans L, Pinho L, Reis J, Sousa F, Baptista M, Resende C, Leitão D, Durães C, Costa JL, Carneiro F, Machado JC
The Adaptive Immune Landscape of the Colorectal Adenoma-Carcinoma Sequence. International journal of molecular sciences 22: ., 2021. [Article] 
 
3. Garcia D, Spaans L, Miranda S, Gonçalves G, Reis J, Costa JL, Durães C, Carneiro F, Machado JC
 doi: 10.20344/amp.12462 PMID: 32416752.
 
.
 
5. Resende C, Gomes CP, Machado JC
Review: Gastric cancer: Basic aspects. Helicobacter 25 Suppl 1: e12739, 2020. [Article; Proceedings Paper] 
 doi: 10.1111/hel.12739 PMID: 32918356.
 
6. Camargo MC, Figueiredo C, Machado JC
Review: Gastric malignancies: Basic aspects. Helicobacter 24 Suppl 1: e12642, 2019. [Review] 
 doi: 10.1111/hel.12642 PMID: 31486241.
 
7. Garcia D, Gullo I, Spaans L, Miranda S, Reis J, Costa JL, Carneiro F, Machado JC
The influence of the genetic and immunologic context in the development of colorectal adenoma Virchows Archiv 475: S200-S200, 2019. [Meeting Abstract] 
.
 
8. Malfertheiner P, Megraud F, O'Morain CA, Gisbert JP, Kuipers EJ, Axon AT, Bazzoli F, Gasbarrini A, Atherton J, Graham DY, Hunt R, Moayyedi P, Rokkas T, Rugge M, Selgrad M, Suerbaum S, Sugano K, El-Omar EM, European Helicobacter and Microbiota Study Group and Consensus panel EM
 
9. Figueiredo C, Camargo MC, Leite M, Fuentes-Pananá EM, Rabkin CS, Machado JC
Pathogenesis of Gastric Cancer: Genetics and Molecular Classification. Current topics in microbiology and immunology 400: 277-304, 2017. [Review; Book Chapter] 
 
10. Azevedo J, Pista A, Lisboa C, Santo I, Azevedo L, Cunha MJ, HERCOLES Study Group MJ
Epidemiology of human papillomavirus on anogenital warts in Portugal - The HERCOLES study. Journal of the European Academy of Dermatology and Venereology : JEADV 31: 1342-1348, 2017. [Article] 
 doi: 10.1111/jdv.14311 PMID: 28485812.
 
11. Figueiredo C, Camargo MC, Leite M, Fuentes-Pananá EM, Rabkin CS, Machado JC
Erratum to: Pathogenesis of Gastric Cancer: Genetics and Molecular Classification. Current topics in microbiology and immunology 400: E1, 2017. [Correction; Book Chapter] 
 
12. Resende C, Regalo G, Durães C, Pinto MT, Wen X, Figueiredo C, Carneiro F, Machado JC
Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPß-associated mechanism. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 19: 74-84, 2016. [Article] 
 
13. Figueiredo C, Costa S, Karameris A, Machado JC
Pathogenesis of Gastric Cancer. Helicobacter 20 Suppl 1: 30-5, 2015. [Article] 
 doi: 10.1111/hel.12254 PMID: 26372822.
 
14. Correia M, Casal S, Vinagre J, Seruca R, Figueiredo C, Touati E, Machado JC
Helicobacter pylori's cholesterol uptake impacts resistance to docosahexaenoic acid. International journal of medical microbiology : IJMM 304: 314-20, 2014. [Article] 
 
15. Figueiredo C, Garcia-Gonzalez MA, Machado JC
Molecular pathogenesis of gastric cancer. Helicobacter 18 Suppl 1: 28-33, 2013. [Review] 
 doi: 10.1111/hel.12083 PMID: 24011242.
 
16. Costa JL, Sousa S, Justino A, Kay T, Fernandes S, Cirnes L, Schmitt F, Machado JC
 doi: 10.1002/humu.22272 PMID: 23315985.
 
17. Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ, European Helicobacter Study Group European Helicobacter Study Group
 
18. Ferreira AC, Suriano G, Mendes N, Gomes B, Wen X, Carneiro F, Seruca R, Machado JC
 doi: 10.1093/hmg/ddr469 PMID: 21989054.
 
19. Botelho MC, Oliveira PA, Lopes C, Correia da Costa JM, Machado JC
 
20. Resende C, Ristimäki A, Machado JC
Genetic and epigenetic alteration in gastric carcinogenesis. Helicobacter 15 Suppl 1: 34-9, 2010. [Review] 
 
21. Regalo G, Resende C, Wen X, Gomes B, Durães C, Seruca R, Carneiro F, Machado JC
C/EBP alpha expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis. Laboratory investigation; a journal of technical methods and pathology 90: 1132-9, 2010. [Article] 
 
22. Botelho M, Oliveira P, Gomes J, Gartner F, Lopes C, da Costa JM, Machado JC
Tumourigenic effect of Schistosoma haematobium total antigen in mammalian cells. International journal of experimental pathology 90: 448-53, 2009. [Article] 
 
23. Ferreira AC, Suriano G, Seruca R, Machado JC
Notch Inhibition Overturns the Apoptosis Resistance Conferred by E-cadherin Deficiency Helicobacter 14: 379-380, 2009. [Meeting Abstract] 
.
 
24. Correia MM, Michel V, Oliveira MJ, Ferreira R, Figueiredo C, Seruca R, Touati E, Machado JC
Omega 3 Docosahexaenoic Acid Inhibits H-pylori Gastric Colonization in C57BL/6 Mice Helicobacter 14: 332-333, 2009. [Meeting Abstract] 
.
 
25. Canedo P, Corso G, Pereira F, Lunet N, Suriano G, Figueiredo C, Pedrazzani C, Moreira H, Barros H, Carneiro F, Seruca R, Roviello F, Machado JC
 
26. Canedo P, Castanheira-Vale AJ, Lunet N, Pereira F, Figueiredo C, Gioia-Patricola L, Canzian F, Moreira H, Suriano G, Barros H, Carneiro F, Seruca R, Machado JC
The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 17: 28-32, 2008. [Article] 
 
27. Canedo P, Durães C, Pereira F, Regalo G, Lunet N, Barros H, Carneiro F, Seruca R, Rocha J, Machado JC
Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 17: 2416-20, 2008. [Article] 
 
28. Resende C, Regalo G, Durães C, Carneiro F, Machado JC
Genetic changes of CEBPA in cancer: mutations or polymorphisms? Journal of clinical oncology : official journal of the American Society of Clinical Oncology 25: 2493-4; author reply 2494-5, 2007. [Letter] 
 
29. Canedo P, Figueiredo C, Machado JC
After Helicobacter pylori, genetic susceptibility to gastric carcinoma revisited. Helicobacter 12 Suppl 2: 45-9, 2007. [Article; Proceedings Paper] 
 
30. Canedo P, Machado JC
Genetic susceptibility to gastric carcinoma. Acta Endoscopica 37:  239-47, 2007. [Article] 
.
 
31. Regalo G, Canedo P, Suriano G, Resende C, Campos ML, Oliveira MJ, Figueiredo C, Rodrigues-Pereira P, Blin N, Seruca R, Carneiro F, Machado JC
 doi: 10.1002/path.2063 PMID: 16981245.
 
32. Regalo G, Wright NA, Machado JC
Trefoil factors: from ulceration to neoplasia. Cellular and molecular life sciences : CMLS 62: 2910-5, 2005. [Review] 
 
.
 
34. Carvalho R, Kayademir T, Soares P, Canedo P, Sousa S, Oliveira C, Leistenschneider P, Seruca R, Gött P, Blin N, Carneiro F, Machado JC
Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma. Laboratory investigation; a journal of technical methods and pathology 82: 1319-26, 2002. [Article] 
 PMID: 12379766.
 
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