José Manuel Lopes
Name: José Manuel Lopes
Academic Degree: PhD

José Manuel Lopes
José Manuel Lopes
Member of
Consultant of Ipatimup Diagnostics

Short CV

José Manuel Lopes, MD, Ph.D., IFCAP, is an Associate Professor of Pathology (Medical Faculty of Porto University), Chief Pathologist of the Department of Anatomic Pathology (Centro Hospitalar Universitário São João), Senior Researcher of I3S, and Senior Consultant at IPATIMUP Diagnósticos. He is a co-author of 300 peer-reviewed publications (h-index: 44) and five chapters of books. His specialization is bone/soft tissue, neuroendocrine, neuropathology, dermatopathology, and urogenital pathology. His research is understanding the pathogenesis and molecular pathology of melanomas, cutaneous, soft tissue, urogenital, and neuroendocrine tumors.

Molecular Pathology: Gists, GEP-NETs and Melanomas

Supervisor of

PI (running)

PI (closed)
First Author
1. Lopes JM, Nesland JM, Reis-Filho JS, Holm R
 PMID: 12010367.
2. Lopes JM, Hannisdal E, Bjerkehagen B, Bruland OS, Danielsen HE, Pettersen EO, Sobrinho-Simões M, Nesland JM
Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology 16: 45-62, 1998. [Article] 
 PMID: 9584899.
3. Lopes JM, Silva P, Seixas M, Cirnes L, Seruca R
 PMID: 9870157.
4. Lopes JM, Bruland OS, Bjerkehagen B, Silva MC, Holm R, Pettersen EO, Solheim OP, Sobrinho-Simões M, Nesland JM
 PMID: 9112270.
Inflammatory fibrosarcoma. Another imitator of Hodgkin's disease? Critical commentary Pathology, research and practice 192: 479–480, 1996. [Editorial Material] 
Critical Commentary to "Carcinoma Arising in Ectopic Hamartomatous Thymoma" Pathology, research and practice 192: 621, 1996. [] 
Critical Commentary to "Spiradenoma Associated with Apocrine Adenoma Component" Pathology, research and practice 192: 1140–1141, 1996. [] 
8. Lopes JM, Bjerkehagen B, Holm R, Bruland O, Sobrinho-Simões M, Nesland JM
 PMID: 7792946.
9. Lopes JM, Bjerkehagen B, Holm R, Bruland O, Sobrinho-Simões M, Nesland JM
 PMID: 7520165.
Critical Commentary Pathology, research and practice 189: 473-474, 1993. [Editorial Material] 
12. Lopes JM, Seruca R, Soares P, Castro-Correia J, Castedo S
Adenoma of the ciliary body- A pathologic and cytogenetic study Cancer genetics and cytogenetics 63: 177, 1992. [] 
13. Lopes JM, Paiva ME
 PMID: 1495851.
Senior Author
1. Castanheira A, Boaventura P, Pais Clemente M, Soares P, Mota A, Lopes JM
Head and neck cutaneous basal cell carcinoma: what should the otorhinolaryngology head and neck surgeon care about? Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 40: 5-18, 2020. [Review] 
2. Vinagre J, Pinheiro J, Martinho O, Reis RM, Preto J, Soares P, Lopes JM
3. Silva C, Pires-Luís AS, Rocha E, Bartosch C, Lopes JM
Phenotypic Intratumoral Heterogeneity of Endometrial Carcinomas. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 37: 154-166, 2018. [Article] 
4. Duarte TL, Caldas C, Santos AG, Silva-Gomes S, Santos-Gonçalves A, Martins MJ, Porto G, Lopes JM
5. Bartosch C, Afonso M, Pires-Luís AS, Galaghar A, Guimarães M, Antunes L, Lopes JM
Distant Metastases in Uterine Leiomyosarcomas: The Wide Variety of Body Sites and Time Intervals to Metastatic Relapse. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 36: 31-41, 2017. [Article] 
6. Bartosch C, Pires M, Jerónimo C, Lopes JM
The role of pathology in the management of patients with endometrial carcinoma. Future oncology (London, England) 13: 1003-1020, 2017. [Review] 
7. Barroca HM, Cirnes L, Lopes JM
Metanephric adenoma: Cytological, histological, and molecular diagnosis of a case. Diagnostic cytopathology 44: 263-6, 2016. [Letter] 
 doi: 10.1002/dc.23427 PMID: 26800350.
8. Bartosch C, Monteiro-Reis S, Vieira R, Pereira A, Rodrigues M, Jerónimo C, Lopes JM
9. Bartosch C, Gomes B, Jerónimo C, Lopes JM
Endometrial carcinoma in Portugal: demographic, diagnostic and treatment changes in the last 5 decades. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 34: 159-68, 2015. [Article] 
10. de Beça FF, Lopes J, Maçoas F, Carneiro F, Lopes JM
Tactoid body features in a Schwann cell hamartoma of colonic mucosa. International journal of surgical pathology 22: 438-41, 2014. [Article] 
11. Celestino R, Lima J, Faustino A, Vinagre J, Máximo V, Gouveia A, Soares P, Lopes JM
12. Barroca H, Lopes JM
 doi: 10.1159/000343890 PMID: 23220889.
13. Caplin M, Sundin A, Nillson O, Baum RP, Klose KJ, Kelestimur F, Plöckinger U, Papotti M, Salazar R, Pascher A, Lopes JM
 doi: 10.1159/000335594 PMID: 22261972.
14. Pópulo H, Soares P, Lopes JM
Insights into melanoma: targeting the mTOR pathway for therapeutics. Expert opinion on therapeutic targets 16: 689-705, 2012. [Review] 
15. Celestino R, Lima J, Faustino A, Máximo V, Gouveia A, Vinagre J, Soares P, Lopes JM
16. Vala H, Pópulo H, Mesquita JR, Esteves F, Santos C, Soares P, Lopes JM
Melanocytic tumour in a black sheep never exposed to ultraviolet radiation. Journal of comparative pathology 146: 160-4, 2012. [Article] 
17. Pópulo H, Soares P, Faustino A, Rocha AS, Silva P, Azevedo F, Lopes JM
mTOR pathway activation in cutaneous melanoma is associated with poorer prognosis characteristics. Pigment cell & melanoma research 24: 254-7, 2011. [Letter] 
18. Bartosch C, Vieira J, Teixeira MR, Lopes JM
19. Pópulo H, Soares P, Rocha AS, Silva P, Lopes JM
Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma. Melanoma research 20: 107-17, 2010. [Article] 
20. Kos-Kudla B, O'Toole D, Falconi M, Gross D, Klöppel G, Sundin A, Ramage J, Oberg K, Wiedenmann B, Komminoth P, Van Custem E, Mallath M, Papotti M, Caplin M, Collaborators, including Lopes JM .
 doi: 10.1159/000287255 PMID: 20484875.
21. Kianmanesh R, Ruszniewski P, Rindi G, Kwekkeboom D, Pape UF, Kulke M, Sevilla Garcia I, Scoazec JY, Nilsson O, Fazio N, Lesurtel M, Chen YJ, Eriksson B, Cioppi F, O'Toole D, Collaborators, including Lopes JM .
 doi: 10.1159/000286700 PMID: 20424420.
22. Bartosch C, Exposito MI, Lopes JM
23. O'Toole D, Rindi G, Plöckinger U, Wiedenmann B, Collaborators, including Lopes JM
 doi: 10.1159/000287272 PMID: 20407213.
24. Martinho O, Gouveia A, Silva P, Pimenta A, Reis RM, Lopes JM
Loss of RKIP expression is associated with poor survival in GISTs. Virchows Archiv : an international journal of pathology 455: 277-84, 2009. [Article] 
25. Martinho O, Gouveia A, Viana-Pereira M, Silva P, Pimenta A, Reis RM, Lopes JM
26. Eriksson B, Klöppel G, Krenning E, Ahlman H, Plöckinger U, Wiedenmann B, Arnold R, Auernhammer C, Körner M, Rindi G, Wildi S, Conference participants Frascati Consensus
 doi: 10.1159/000111034 PMID: 18097129.
27. Plöckinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, de Herder WW, Gross D, Knapp WH, Knigge UP, Kulke MH, Pape UF, Frascati Consensus Conference participants, including Lopes JM
 doi: 10.1159/000109876 PMID: 17934252.
28. Ramage JK, Goretzki PE, Manfredi R, Komminoth P, Ferone D, Hyrdel R, Kaltsas G, Kelestimur F, Kvols L, Scoazec JY, Garcia MI, Caplin ME, Frascati Consensus Conference participants, including Lopes JM
 doi: 10.1159/000111036 PMID: 18097130.
29. Ahlman H, Nilsson O, McNicol AM, Ruszniewski P, Niederle B, Ricke J, Jensen R, Kos-Kudla B, Oberg K, O'Connor JM, Pavel ME, Vullierme MP, Conference participants Frascati Consensus
Poorly-differentiated endocrine carcinomas of midgut and hindgut origin. Neuroendocrinology 87: 40-6, 2008. [Article; Proceedings Paper] 
 doi: 10.1159/000109976 PMID: 17940332.
30. Gouveia AM, Pimenta AP, Capelinha AF, de la Cruz D, Silva P, Lopes JM
Surgical margin status and prognosis of gastrointestinal stromal tumor. World journal of surgery 32: 2375-82, 2008. [Article] 
31. Gomes AL, Gouveia A, Capelinha AF, de la Cruz D, Silva P, Reis RM, Pimenta A, Lopes JM
Molecular alterations of KIT and PDGFRA in GISTs: evaluation of a Portuguese series. Journal of clinical pathology 61: 203-8, 2008. [Article] 
32. Barroca H, Farinha NJ, Lobo A, Monteiro J, Lopes JM
 PMID: 17536559.
33. Gouveia A, Pimenta A, Lopes JM
Quando e como operar os tumours estromais gastrointestinais primários. Revista Portuguesa de Cirurgia 1: 49-52, 2007. [] 
34. Reis RM, Reis-Filho JS, Longatto Filho A, Tomarev S, Silva P, Lopes JM
35. Reis RM, Martins A, Ribeiro SA, Basto D, Longatto-Filho A, Schmitt FC, Lopes JM
Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas. Cellular oncology : the official journal of the International Society for Cellular Oncology 27: 319-26, 2005. [Article] 
 PMID: 16373964.
36. Veloso FT, Pereira P, Saraiva A, Capelinha AF, Lopes JM
Colonic gastrointestinal autonomic nervous tumor in a patient with Crohn's disease. Digestive diseases and sciences 50: 1476-80, 2005. [Article] 
 PMID: 16110839.
37. Reis-Filho JS, Paiva ME, Lopes JM
August 2003: 47-year-old female with a 7-year history of osteomalacia and hypophosphatemia. Brain pathology (Zurich, Switzerland) 14: 111-2, 115, 2004. [Article] 
 PMID: 14997944.
38. Cruz J, Reis-Filho JS, Lopes JM
Malignant peripheral nerve sheath tumour-like primary cutaneous malignant melanoma. Journal of clinical pathology 57: 218-20, 2004. [Article] 
 PMID: 14747458.
39. Cruz J, Reis-Filho JS, Silva P, Lopes JM
 doi: 10.1159/000071207 PMID: 12837985.
40. Cruz J, Reis-Filho JS, Lopes JM
Primary cutaneous malignant melanoma with lipoblast-like cells. Archives of pathology & laboratory medicine 127: 370-1, 2003. [Editorial Material] 
 PMID: 12653588.
41. Reis-Filho JS, Lopes JM
Pathologic quiz case: a 53-year-old man with a slowly enlarging mass in the right leg. Archives of pathology & laboratory medicine 127: 627-8, 2003. [Editorial Material] 
 PMID: 12708914.
42. Cruz J, Reis-Filho JS, Lopes JM
Cutaneous malignant melanoma: the great simulator. International journal of surgical pathology 11: 35, 2003. [Article] 
 PMID: 12598916.
43. Reis-Filho JS, Paiva ME, Lopes JM
 PMID: 12028155.
44. Reis-Filho JS, Souto-Moura C, Lopes JM
Classic Kaposi's sarcoma of the tongue: case report with emphasis on the differential diagnosis. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 60: 951-4, 2002. [Editorial Material] 
 PMID: 12149747.
45. Reis-Filho JS, Paiva ME, Lopes JM
 PMID: 12385334.
46. Reis-Filho JS, Silva P, Milanezi F, Lopes JM
Hyaline cell-rich chondroid syringoma: case report and review of the literature. Pathology, research and practice 198: 755-64, 2002. [Article] 
 PMID: 12530579.
47. Cruz D, Melo N, Seixas M, Lopes JM
Measuring beyond the microscope field of view using digital images in squamous cell carcinoma of the lip. Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 23: 245-50, 2001. [Article] 
 PMID: 11531138.
48. Schmitt FC, Ribeiro CA, Alvarenga S, Lopes JM
 PMID: 10809602.
Critical Commentary to "Carcinoma Arising in Ectopic Hamartomatous Thymoma" Pathology, research and practice 192: 621, 1996. [] 
Critical Commentary to "Spiradenoma Associated with Apocrine Adenoma Component" Pathology, research and practice 192: 1140–1141, 1996. [] 
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