Paula Soares
Name: Paula Soares
Academic Degree: PhD

Paula Soares
Paula Soares
Member of
Consultant of Ipatimup Diagnostics

Short CV

Paula Soares, BSc, MSc, PhD, is Assistant Professor of Biopathology at the Medical Faculty of Porto and coordinates the Group of Cancer Biology at the IPATIMUP/Cancer signaling and Metabolism at I3S. She received her Biology degree in Science Faculty, University of Porto and MSc and PhD degrees at the Medical Faculty, University of Porto. Her main research interests include oncobiology of thyroid and other neuroendocrine tumors, mainly addressing the cellular and molecular biology of thyroid tumors. Her team identify BRAF and TERT promoter mutations in thyroid tumors and become one of the world?s most cited group in thyroid carcinogenesis. Besides participating or leading several national and international funded projects, the practical relevance of Paula?s work has allowed her to secure funding and collaborations from several major pharmaceutical companies. She has over 240 papers (including book chapters) in peer-reviewed journals, mainly addressing the cellular and molecular biology of thyroid tumors, with over 8.000 citations and an h-index of 45. She is also a member of numerous scientific committees and evaluation boards and serves on grant review committees and in journal editorial and review boards.

Cellular and molecular biology of thyroid tumors

Supervisor of
Adriana Silva, Master Student (theoretical phase)
MSc student
Antónia Póvoa, Assistant Professor
External Researcher
Arnaud Paula, Assistant Researcher
Assistant Researcher
Bárbara Ferreira, External Consultant
Research Fellowship (MSc)
Bruno Carvalho, Assistant Professor
César Martins, PhD Student
PhD student
Elisabete Rios, PhD Student
PhD student
Elisabete Teixeira, Research Fellowship (MSc)
João Brás, Junior Researcher
Junior Researcher
João Vinagre, Assistant Researcher
Assistant Researcher
Jorge Lima, Researcher
Leandro Miranda-Alves, Visiting Researcher
Visiting Researcher
Lucas Caridade, Research Trainee
Research Trainee
Luís Cardoso, PhD Student
PhD student
Nuno Mendes, Research Technician
Team Member
Raquel Lima, Collaborator
External Consultant
Rui Batista, Collaborator
Visiting Researcher
Rui Martins, Master Student (theoretical phase)
MSc student
Sara Soares, Research Trainee
Research Trainee
Tiago Gaspar, Assistant Professor
External Researcher
Tito Jesus, Junior Researcher
Junior Researcher

PI (running)

PI (closed)
First Author
2. Martins-Mendes D, Monteiro-Soares M, Boyko EJ, Ribeiro M, Barata P, Lima J, Soares R
The independent contribution of diabetic foot ulcer on lower extremity amputation and mortality risk. Journal of diabetes and its complications 28: 632-8, 2014. [Article] 
Papillary Thyroid Microcarcinoma: How to Diagnose and Manage this Epidemic? International journal of surgical pathology 22: 113-9, 2014. [Article] 
Prognostic biomarkers in thyroid cancer. Virchows Archiv : an international journal of pathology 464: 333-46, 2014. [Review] 
5. Celestino R, Lima J, Faustino A, Máximo V, Gouveia A, Vinagre J, Soares P, Lopes JM
6. Soares P, Lima J, Preto A, Castro P, Vinagre J, Celestino R, Couto JP, Prazeres H, Eloy C, Máximo V, Sobrinho-Simões M
Cancer: Small papillary thyroid cancers--is BRAF of prognostic value? Nature reviews. Endocrinology 7: 9-10, 2011. [Editorial Material] 
Is BRAF mutation screening useful for preoperative risk stratification in papillary thyroid cancer? Future oncology (London, England) 5: 1225-9, 2009. [Article] 
 doi: 10.2217/fon.09.81 PMID: 19852736.
9. Soares P, Trovisco V, Rocha AS, Feijão T, Rebocho AP, Fonseca E, Vieira de Castro I, Cameselle-Teijeiro J, Cardoso-Oliveira M, Sobrinho-Simões M
10. Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, Máximo V, Botelho T, Seruca R, Sobrinho-Simões M
 PMID: 15357248.
 PMID: 10589793.
13. Soares P, Fonseca E, Wynford-Thomas D, Sobrinho-Simões M
14. Soares P, Berx G, van Roy F, Sobrinho-Simões M
E-cadherin gene alterations are rare events in thyroid tumors. International journal of cancer 70: 32-8, 1997. [Article] 
 PMID: 8985087.
15. Soares P, dos Santos NR, Seruca R, Lothe RA, Sobrinho-Simões M
Benign and malignant thyroid lesions show instability at microsatellite loci. European journal of cancer (Oxford, England : 1990) 33: 293-6, 1997. [Article] 
 PMID: 9135503.
Recent advances in cytometry, cytogenetics and molecular genetics of thyroid tumours and tumour-like lesions. Pathology, research and practice 191: 304-17, 1995. [Article; Proceedings Paper] 
 PMID: 7479347.
17. Soares P, Cameselle-Teijeiro J, Sobrinho-Simões M
 PMID: 8200621.
Expression of C-erb B2 in tumours and tumour-like lesions of the thyroid. International journal of cancer 56: 459-61, 1994. [Letter] 
 PMID: 7906256.
 PMID: 7910779.
Senior Author
1. Macedo S, Pestana A, Santos L, Neves C, Guimarães S, Duarte-Neto A, Dolhnikoff M, Saldiva P, Alves G, Oliveira R, Cabanes D, Carneiro F, Sobrinho-Simões M, Soares P
 doi: 10.1530/ETJ-22-0074 PMID: 35900859.
2. Boaventura P, Macedo S, Ribeiro F, Jaconiano S, Soares P
Post-COVID-19 Condition: Where Are We Now? Life (Basel, Switzerland) 12: ., 2022. [Review] 
3. Póvoa AA, Teixeira E, Bella-Cueto MR, Batista R, Pestana A, Melo M, Alves T, Pinto M, Sobrinho-Simões M, Maciel J, Soares P
4. Pópulo H, Domingues B, Sampaio C, Lopes JM, Soares P
Combinatorial Therapies to Overcome BRAF/MEK Inhibitors Resistance in Melanoma Cells: An in vitro Study. Journal of experimental pharmacology 13: 521-535, 2021. [Article] 
 doi: 10.2147/JEP.S297831 PMID: 34079392.
Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review. Diagnostics (Basel, Switzerland) 10: ., 2020. [Review] 
6. Batista R, Lima L, Vinagre J, Pinto V, Lyra J, Máximo V, Santos L, Soares P
TERT Promoter Mutation as a Potential Predictive Biomarker in BCG-Treated Bladder Cancer Patients. International journal of molecular sciences 21: ., 2020. [Article] 
7. Ferreira LB, Gimba E, Vinagre J, Sobrinho-Simões M, Soares P
Molecular Aspects of Thyroid Calcification. International journal of molecular sciences 21: ., 2020. [Review] 
8. Sieverink CA, Batista RPM, Prazeres HJM, Vinagre J, Sampaio C, Leão RR, Máximo V, Witjes JA, Soares P
9. Póvoa AA, Teixeira E, Bella-Cueto MR, Melo M, Oliveira MJ, Sobrinho-Simões M, Maciel J, Soares P
10. Pestana A, Batista R, Celestino R, Canberk S, Sobrinho-Simões M, Soares P
11. Campos MA, Macedo S, Fernandes MS, Pestana A, Pardal J, Batista R, Vinagre J, Sanches A, Baptista A, Lopes JM, Soares P
12. Dionísio de Sousa IJ, Marques DS, Príncipe C, Portugal RV, Canberk S, Prazeres H, Lopes JM, Gimba ERP, Lima RT, Soares P
Predictive Biomarkers and Patient Outcome in Platinum-Resistant (PLD-Treated) Ovarian Cancer. Diagnostics (Basel, Switzerland) 10: ., 2020. [Article] 
13. Batista R, Vinagre J, Prazeres H, Sampaio C, Peralta P, Conceição P, Sismeiro A, Leão R, Gomes A, Furriel F, Oliveira C, Torres JN, Eufrásio P, Azinhais P, Almeida F, Gonzalez ER, Bidovanets B, Ecke T, Stinjs P, Pascual ÁS, Abdelmalek R, Villafruela A, Beardo-Villar P, Fidalgo N, Öztürk H, Gonzalez-Enguita C, Monzo J, Lopes T, Álvarez-Maestro M, Servan PP, De La Cruz SMP, Perez MPS, Máximo V, Soares P
14. Campos MA, Macedo S, Fernandes M, Pestana A, Pardal J, Batista R, Vinagre J, Sanches A, Baptista A, Lopes JM, Soares P
TERT promoter mutations are associated with poor prognosis in cutaneous squamous cell carcinoma. Journal of the American Academy of Dermatology 80: 660-669.e6, 2019. [Article] 
15. Santos LR, Durães C, Ziros PG, Pestana A, Esteves C, Neves C, Carvalho D, Bongiovanni M, Renaud CO, Chartoumpekis DV, Habeos IG, Simões MS, Soares P, Sykiotis GP
Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis. Thyroid : official journal of the American Thyroid Association 29: 1302-1315, 2019. [Article] 
16. Tavares C, Coelho MJ, Eloy C, Melo M, da Rocha AG, Pestana A, Batista R, Ferreira LB, Rios E, Selmi-Ruby S, Cavadas B, Pereira L, Sobrinho Simões M, Soares P
 doi: 10.1530/EC-17-0302 PMID: 29298843.
17. Celestino R, Nome T, Pestana A, Hoff AM, Gonçalves AP, Pereira L, Cavadas B, Eloy C, Bjøro T, Sobrinho-Simões M, Skotheim RI, Soares P
19. Sousa I, Rodrigues F, Prazeres H, Lima RT, Soares P
Liposomal therapies in oncology: does one size fit all? Cancer chemotherapy and pharmacology 82: 741-755, 2018. [Review] 
20. Ferreira LB, Lima RT, Bastos ACSDF, Silva AM, Tavares C, Pestana A, Rios E, Eloy C, Sobrinho-Simões M, Gimba ERP, Soares P
OPNa Overexpression Is Associated with Matrix Calcification in Thyroid Cancer Cell Lines. International journal of molecular sciences 19: ., 2018. [Article] 
21. Boaventura P, Durães C, Mendes A, Costa NR, Chora I, Ferreira S, Araújo E, Lopes P, Rosa G, Marques P, Tavares S, Chaves V, Bettencourt P, Oliveira I, Costa F, Ramos I, Teles MJ, Guimarães JT, Sobrinho-Simões M, Soares P
Is Low-Dose Radiation Exposure a Risk Factor for Atherosclerotic Disease? Radiation research 189: 418-424, 2018. [Article] 
 doi: 10.1667/RR14942.1 PMID: 29461943.
22. Melo M, Gaspar da Rocha A, Batista R, Vinagre J, Martins MJ, Costa G, Ribeiro C, Carrilho F, Leite V, Lobo C, Cameselle-Teijeiro JM, Cavadas B, Pereira L, Sobrinho-Simões M, Soares P
TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease. The Journal of clinical endocrinology and metabolism 102: 1898-1907, 2017. [Article] 
TERT biology and function in cancer: beyond immortalisation. Journal of molecular endocrinology 58: R129-R146, 2017. [Review] 
 doi: 10.1530/JME-16-0195 PMID: 28057768.
24. Rodrigues AC, Penna G, Rodrigues E, Castro P, Sobrinho-Simões M, Soares P
25. Pópulo H, Nunes B, Sampaio C, Batista R, Pinto MT, Gaspar TB, Miranda-Alves L, Cai RZ, Zhang XY, Schally AV, Sobrinho-Simões M, Soares P
26. Boaventura P, Batista R, Pestana A, Reis M, Mendes A, Eloy C, Sobrinho-Simões M, Soares P
 doi: 10.1530/EJE-16-0740 PMID: 27760791.
27. Cappagli V, Potes CS, Ferreira LB, Tavares C, Eloy C, Elisei R, Sobrinho-Simões M, Wookey PJ, Soares P
 doi: 10.7717/peerj.3778 PMID: 28929017.
28. Pópulo H, Batista R, Sampaio C, Pardal J, Lopes JM, Soares P
29. Amorim JP, Santos G, Vinagre J, Soares P
30. Penna GC, Vaisman F, Vaisman M, Sobrinho-Simões M, Soares P
Molecular Markers Involved in Tumorigenesis of Thyroid Carcinoma: Focus on Aggressive Histotypes. Cytogenetic and genome research 150: 194-207, 2016. [Review] 
 doi: 10.1159/000456576 PMID: 28231576.
31. Ferreira LB, Tavares C, Pestana A, Pereira CL, Eloy C, Pinto MT, Castro P, Batista R, Rios E, Sobrinho-Simões M, Gimba ER, Soares P
32. Ferreira LB, Eloy C, Pestana A, Lyra J, Moura M, Prazeres H, Tavares C, Sobrinho-Simões M, Gimba E, Soares P
 doi: 10.1530/EJE-15-0577 PMID: 26811408.
33. Vinagre J, Nabais J, Pinheiro J, Batista R, Oliveira RC, Gonçalves AP, Pestana A, Reis M, Mesquita B, Pinto V, Lyra J, Cipriano MA, Ferreira MG, Lopes JM, Sobrinho-Simões M, Soares P
 doi: 10.1038/srep29714 PMID: 27411289.
34. Boaventura P, Durães C, Mendes A, Costa NR, Chora I, Ferreira S, Araújo E, Lopes P, Rosa G, Marques P, Bettencourt P, Oliveira I, Costa F, Ramos I, Teles MJ, Guimarães JT, Sobrinho-Simões M, Soares P
35. Tavares C, Coelho MJ, Melo M, da Rocha AG, Pestana A, Batista R, Salgado C, Eloy C, Ferreira L, Rios E, Sobrinho-Simões M, Soares P
pmTOR is a marker of aggressiveness in papillary thyroid carcinomas. Surgery 160: 1582-1590, 2016. [Article] 
Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis? Journal of clinical oncology : official journal of the American Society of Clinical Oncology 33: 667-8, 2015. [Letter] 
37. Pópulo H, Caldas R, Lopes JM, Pardal J, Máximo V, Soares P
RE: TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma. Journal of the National Cancer Institute 107: 1, 2015. [Letter] 
 doi: 10.1093/jnci/djv049 PMID: 25755155.
39. Melo M, da Rocha AG, Vinagre J, Batista R, Peixoto J, Tavares C, Celestino R, Almeida A, Salgado C, Eloy C, Castro P, Prazeres H, Lima J, Amaro T, Lobo C, Martins MJ, Moura M, Cavaco B, Leite V, Cameselle-Teijeiro JM, Carrilho F, Carvalheiro M, Máximo V, Sobrinho-Simões M, Soares P
TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas. The Journal of clinical endocrinology and metabolism 99: E754-65, 2014. [Article] 
40. Pópulo H, Boaventura P, Vinagre J, Batista R, Mendes A, Caldas R, Pardal J, Azevedo F, Honavar M, Guimarães I, Manuel Lopes J, Sobrinho-Simões M, Soares P
TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X-Irradiation. The Journal of investigative dermatology 134: 2251-7, 2014. [Article] 
41. Vinagre J, Pinto V, Celestino R, Reis M, Pópulo H, Boaventura P, Melo M, Catarino T, Lima J, Lopes JM, Máximo V, Sobrinho-Simões M, Soares P
Telomerase promoter mutations in cancer: an emerging molecular biomarker? Virchows Archiv : an international journal of pathology 465: 119-33, 2014. [Review] 
42. Santos LR, Durães C, Mendes A, Prazeres H, Alvelos MI, Moreira CS, Canedo P, Esteves C, Neves C, Carvalho D, Sobrinho-Simões M, Soares P
A Polymorphism in the Promoter Region of the Selenoprotein S Gene (SEPS1) Contributes to Hashimoto's Thyroiditis Susceptibility. The Journal of clinical endocrinology and metabolism 99: E719-23, 2014. [Article] 
43. Durães C, Moreira CS, Alvelos I, Mendes A, Santos LR, Machado JC, Melo M, Esteves C, Neves C, Sobrinho-Simões M, Soares P
44. Lyra J, Vinagre J, Batista R, Pinto V, Prazeres H, Rodrigues F, Eloy C, Sobrinho-Simões M, Soares P
mTOR activation in medullary thyroid carcinoma with RAS mutation. European journal of endocrinology 171: 633-40, 2014. [Article] 
 doi: 10.1530/EJE-14-0389 PMID: 25163725.
45. Boaventura P, Pereira D, Mendes A, Batista R, da Silva AF, Guimarães I, Honavar M, Teixeira-Gomes J, Lopes JM, Máximo V, Soares P
47. Vinagre J, Almeida A, Pópulo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R, Prazeres H, Lima L, Melo M, Rocha AG, Preto A, Castro P, Castro L, Pardal F, Lopes JM, Santos LL, Reis RM, Cameselle-Teijeiro J, Sobrinho-Simões M, Lima J, Máximo V, Soares P
Frequency of TERT promoter mutations in human cancers. Nature communications 4: 2185, 2013. [Article] 
 doi: 10.1038/ncomms3185 PMID: 23887589.
48. Melo M, Costa G, Ribeiro C, Carrilho F, Martins MJ, da Rocha AG, Sobrinho-Simões M, Carvalheiro M, Soares P
Stimulated Thyroglobulin at Recombinant Human TSH-Aided Ablation Predicts Disease-free Status One Year Later. The Journal of clinical endocrinology and metabolism 98: 4364-72, 2013. [Article] 
49. Alvelos MI, Vinagre J, Fonseca E, Barbosa E, Teixeira-Gomes J, Sobrinho-Simões M, Soares P
 doi: 10.1530/EJE-12-0327 PMID: 23093699.
50. Pópulo H, Tavares S, Faustino A, Nunes JB, Lopes JM, Soares P
 doi: 10.7717/peerj.104 PMID: 23904987.
51. Boaventura P, Pereira D, Celestino R, Mendes A, Nakasawa T, Teixeira-Gomes J, Sobrinho-Simões M, Soares P
Genetic alterations in thyroid tumors from patients irradiated in childhood for tinea capitis treatment. European journal of endocrinology 169: 673-679, 2013. [Article] 
 doi: 10.1530/EJE-13-0543 PMID: 23966419.
52. Prazeres H, Salgado C, Duarte C, Soares P
LRP1B (low density lipoprotein receptor-related protein 1B) Atlas Genet Cytogenet Oncol Haematol  ., 2013. [] 
53. Melo M, Costa G, Carrilho F, Soares P
54. Pópulo H, Lopes JM, Soares P
The mTOR Signalling Pathway in Human Cancer. International journal of molecular sciences 13: 1886-918, 2012. [Review] 
55. Faustino A, Couto JP, Pópulo H, Rocha AS, Pardal F, Cameselle-Teijeiro JM, Lopes JM, Sobrinho-Simões M, Soares P
mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma. The Journal of clinical endocrinology and metabolism 97: E1139-49, 2012. [Article] 
56. Couto JP, Almeida A, Daly L, Sobrinho-Simões M, Bromberg JF, Soares P
57. Prazeres H, Torres J, Rodrigues F, Pinto M, Pastoriza MC, Gomes D, Cameselle-Teijeiro J, Vidal A, Martins TC, Sobrinho-Simões M, Soares P
58. Pópulo H, Vinagre J, Lopes JM, Soares P
Analysis of GNAQ mutations, proliferation and MAPK pathway activation in uveal melanomas. The British journal of ophthalmology 95: 715-9, 2011. [Article] 
59. Goncalves AP, Videira A, Maximo V, Soares P
 PMID: 21857110.
60. Prazeres H, Torres J, Rodrigues F, Couto JP, Vinagre J, Sobrinho-Simões M, Soares P
 doi: 10.4061/2011/678357 PMID: 21765992.
Hot topics in papillary thyroid carcinoma. International journal of surgical pathology 18: 190S-193S, 2010. [Article; Proceedings Paper] 
62. Sobrinho-Simões M, Máximo V, Rocha AS, Trovisco V, Castro P, Preto A, Lima J, Soares P
Intragenic mutations in thyroid cancer. Endocrinology and metabolism clinics of North America 37: 333-62, viii, 2008. [Review] 
63. Rocha AS, Marques R, Bento I, Soares R, Magalhães J, de Castro IV, Soares P
 doi: 10.1677/JOE-06-0009 PMID: 17210745.
Molecular pathology of well-differentiated thyroid carcinomas. Virchows Archiv : an international journal of pathology 447: 787-93, 2005. [Review] 
65. Rocha AS, De Wever O, Moreira S, Costa MJ, Vandekerckhove J, Mareel M, Soares P
Mutated E-cadherin: genomic and functional characterization in thyroid cells from the KAT family. Thyroid : official journal of the American Thyroid Association 14: 902-9, 2004. [Article] 
 PMID: 12075405.
67. Preto A, Reis-Filho JS, Ricardo S, Soares P
 PMID: 12234063.
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