Carla Oliveira
Name: Carla Oliveira
Academic Degree: Doctor of philosophy

Carla Oliveira
Carla Oliveira
Member of
Consultant of Ipatimup Diagnostics

Short CV
Education and Training
2004-2005: Post-doc fellow Pathology Dept and Laboratory Medicine, Univ. British Columbia, Vancouver, Canada
2002-2004: Post-doc fellow Cancer Genetics Group, Ipatimup
2002/03/15: Ph.D. in Human Biology, GABBA Ph.D. Program, Medical Fac., Univ. Porto
2001-2002: Ph.D. student Cancer Genetics Group, Ipatimup
1999-2001: Visiting Ph.D. student, Cambridge Institute for Medical Research, Cambridge Univ., UK
1995-1996: Degree Training at IBILI, Coimbra, Portugal
1991-1995: Biochemistry Degree, Faculty of Science and Technology, Univ. Coimbra

Research Positions
2013/01-present: Group Leader of the Expression Regulation in Cancer Group, Ipatimup
2011/09-2012/08: Guest Scientist, E Izaurralde’s lab, Max Planck Institute, Tuebingen, Germany
2011/01-present: Principal Investigator with tenure, Ipatimup
2008/01-2010/12: Team Leader and Independent Researcher in Cancer Genetics Group, Ipatimup
2006/01-present: Affiliated Professor, Medical Faculty of Univ. Porto
2005/07-2010/12: Researcher in the Cancer Genetics Group, Ipatimup

• Current supervision of 4 Post-docs; co-supervision of 2 Post-docs; supervision of 1 Ph.D student and co-supervision of 2 Ph.D students
• Past Supervision of 1 Post-doc, 5 Ph.D., 3 Masters and 5 Degree Training Thesis

• Fellowships already funded and anchored in Carla Oliveira’s team research:
- 6 PhD and 3 Post-doc Fellowships, FCT (Portuguese Science & Technology Foundation( (2008-2015)
- 4 EMBO Short Term Fellowships (2008-2011)

• Member of the Scientific Program Committee (SPC) and Organizer of European Human Genetics Conferences (2010-2013)
• Member of the SPC and Organizer of Portuguese Society of Human Genetics Conferences (2010-2013)
• Regular Reviewer of at least 20 Peer Review Journals and National and International Funding Agencies

The “EXPRESSION REGULATION IN CANCER” group aims, in the next three years, to identification cancer-associated expression regulatory mechanisms that impact early diagnosis, prognosis and chemotherapy-induced resistance in cancer.

Specific aims:
1. Identify the molecular basis of familial gastric cancer (HDGC and Familial Intestinal Gastric Cancer - FIGC);
2. Uncover somatic regulation in gastric cancer and its relationship with patients’ prognosis;
3. Optimize tools for early diagnosis of gastric cancer;
4. Uncover mechanisms involved in metastasis and chemotherapy-induced resistance using Epithelial-Mesenchymal-Epithelial transitions (EMT/MET) experimental models;
5. Unravel the role of mRNA mistranslation in human cancer.

Supervisor of
Ana André, Visiting Researcher
Rita Matos, PhD Student
Ana Rita Monteiro, Visiting Researcher
Celina São José, PhD Student
Clara Borges, Visiting Researcher
Diana Martins, External Researcher
Francisco Almeida, Master Student (thesis)
Hugo Pinheiro, External Researcher
Irene Gullo, Visiting Researcher
Joana Guerra, PhD Student
Joana Carvalho, Junior Researcher
Joaquín Jurado Maqueda, Visiting Researcher
Liliana Sousa, PhD Student
Marta Ferreira, Visiting Researcher
Nuno P. Teixeira, Master Student (thesis)
Pedro Ferreira, Researcher
Rúben Rodrigues, PhD Student
Sara Rocha, PhD Student
Silvana Lobo, Visiting Researcher

PI (running)

PI (closed)
First Author
E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer. Progress in molecular biology and translational science 116: 337-59, 2013. [Review; Book Chapter] 
3. Oliveira C, Seruca R, Hoogerbrugge N, Ligtenberg M, Carneiro F
Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC). European journal of human genetics : EJHG 21: ., 2013. [Editorial Material] 
4. Oliveira C, Senz J, Kaurah P, Pinheiro H, Sanges R, Haegert A, Corso G, Schouten J, Fitzgerald R, Vogelsang H, Keller G, Dwerryhouse S, Grimmer D, Chin SF, Yang HK, Jackson CE, Seruca R, Roviello F, Stupka E, Caldas C, Huntsman D
Germline CDH1 deletions in hereditary diffuse gastric cancer families. Human molecular genetics 18: 1545-55, 2009. [Article] 
 doi: 10.1093/hmg/ddp046 PMID: 19168852.
5. Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carriço R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmão L, Wen X, Cipriano MA, Yokota J, Carneiro F, Huntsman D, Seruca R
Hereditary gastric cancer. Best practice & research. Clinical gastroenterology 23: 147-57, 2009. [Article] 
7. Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha AF, Duval A, Hamelin R, Machado JC, Schwartz S, Carneiro F, Seruca R
Genetics, pathology, and clinics of familial gastric cancer. International journal of surgical pathology 14: 21-33, 2006. [Review] 
 PMID: 16501831.
9. Oliveira C, Velho S, Domingo E, Preto A, Hofstra RM, Hamelin R, Yamamoto H, Seruca R, Schwartz S
10. Oliveira C, Moreira H, Seruca R, de Oliveira MC, Carneiro F
Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family. Virchows Archiv : an international journal of pathology 446: 181-4, 2005. [Article] 
11. Oliveira C, Westra JL, Arango D, Ollikainen M, Domingo E, Ferreira A, Velho S, Niessen R, Lagerstedt K, Alhopuro P, Laiho P, Veiga I, Teixeira MR, Ligtenberg M, Kleibeuker JH, Sijmons RH, Plukker JT, Imai K, Lage P, Hamelin R, Albuquerque C, Schwartz S, Lindblom A, Peltomaki P, Yamamoto H, Aaltonen LA, Seruca R, Hofstra RM
 doi: 10.1093/hmg/ddh238 PMID: 15294875.
12. Oliveira C, Ferreira P, Nabais S, Campos L, Ferreira A, Cirnes L, Alves CC, Veiga I, Fragoso M, Regateiro F, Dias LM, Moreira H, Suriano G, Machado JC, Lopes C, Castedo S, Carneiro F, Seruca R
13. Oliveira C, de Bruin J, Nabais S, Ligtenberg M, Moutinho C, Nagengast FM, Seruca R, van Krieken H, Carneiro F
14. Oliveira C, Suriano G, Ferreira P, Canedo P, Kaurah P, Mateus R, Ferreira A, Ferreira AC, Oliveira MJ, Figueiredo C, Carneiro F, Keller G, Huntsman D, Machado JC, Seruca R
Genetic screening for familial gastric cancer. Hereditary Cancer in Clinical Practice 2: 51-64, 2004. [] 
15. Oliveira C, Pinto M, Duval A, Brennetot C, Domingo E, Espín E, Armengol M, Yamamoto H, Hamelin R, Seruca R, Schwartz S
16. Oliveira C, Seruca R, Caldas C
Genetic screening for hereditary diffuse gastric cancer. Expert review of molecular diagnostics 3: 201-15, 2003. [Review] 
17. Oliveira C, Bordin MC, Grehan N, Huntsman D, Suriano G, Machado JC, Kiviluoto T, Aaltonen L, Jackson CE, Seruca R, Caldas C
 doi: 10.1002/humu.10068 PMID: 11968083.
 PMID: 9777952.
Senior Author
1. Garrido L, Nercio T, Leal R, Guimaraes R, Ferro L, Vilarinho L, Costa S, Magalhaes A, Mesquita AS, Pereira AF, Gullo I, Pinheiro H, Sousa S, Carvalho B, Neto AP, Capela L, Teixeira C, Fareleira A, Devezas V, Macedo G, Preto J, Barbosa J, Baptista M, Pinto G, Damasceno M, Fougo JL, Costa-Maia J, Fernandes S, Carneiro F, Castedo S, Oliveira C
Genetic counselling in hereditary diffuse gastric cancer: economical and psycho-social impact European journal of human genetics : EJHG 27: 673-674, 2019. [Meeting Abstract] 
2. Jose CS, Ferro A, Oliveira P, Carvalho J, Pinheiro H, Huntsman D, Acuna-Hidalgo R, Mundlos S, Oliveira C
CDH1 intronic Cis-Regulatory Elements control CDH1 gene tissue-specific expression European journal of human genetics : EJHG 27: 1609-1610, 2019. [Meeting Abstract] 
3. Garrido L, Leal R, Aguiar A, Seixas S, Ferro L, Vilarinho L, Gullo I, Devezas V, Oliveira R, Fernandes S, Magalhaes A, Baptista M, Carneiro F, Castedo S, Oliveira C
The first CDH1 founder mutation in Portugal: Risk assessment and clinical management European journal of human genetics : EJHG 27: 1787-1787, 2019. [Meeting Abstract] 
4. Rocha S, Teles SP, Azevedo M, Oliveira P, Carvalho J, Oliveira C
5. Matos R, Mesquita B, Oliveira P, Valente S, Pinheiro H, Carvalho J, Ferro A, Huntsman D, oliveira C
6. Lemos D, Oliveira P, Carvalho J, Jose CS, Oliveira C
Annotator: a novel custom tool for genomic variants annotation and classification European journal of human genetics : EJHG 27: 1033-1033, 2019. [Meeting Abstract] 
7. Pelaez JG, Monteiro A, Sousa L, Castedo S, Michils G, Bours V, de Putter R, Golmard L, Blanluet M, Colas C, Benusiglio P, Aretz S, Spier I, Huneburg R, Gieldon L, Schrock E, Holinski-Feder E, Steinke V, Calistri D, Tedaldi G, Nadia-Ranzani G, Genuardi M, Silveira C, Krajc M, Blatnik A, Novakovic S, Patino-Garcia A, Soto J, Lazaro C, Capella G, Brunet-Vidal J, Balmana J, Dominguez-Garrido E, Ligtenberg M, Fewings E, Fitzgerald R, Woodward E, Evans G, Hanson H, Lagerstedt-Robinson K, Bajalica-Lagercrantz S, Teixeira M, Hoogerbrugge N, Tischkowitz M, Oliveira C
European Landscape of CDH1 germline mutations: a new tool to understand hereditary diffuse gastric cancer (HDGC) European journal of human genetics : EJHG 27: 1126-1128, 2019. [Meeting Abstract] 
8. Barbosa-Matos R, Ferro A, Oliveira P, Mesquita B, Andre A, Pinheiro H, Carvalho J, Senz J, Kaurah P, Bordeira-Carrico R, Bessa J, Huntsman D, Oliveira C
Structural variations at CDH1 intronic cis-regulatory elements cause CDH1/E-cadherin loss of function European journal of human genetics : EJHG 27: 1131-1132, 2019. [Meeting Abstract] 
9. Lopes-De-Almeida M, Garrido L, Oliveira JP, Castedo S, Oliveira C
10. Garrido L, Nercio T, Leal R, Guimaraes R, Ferro L, Vilarinho L, Costa S, Magalhaes A, Mesquita AS, Pereira AF, Gullo I, Pinheiro H, Sousa S, Carvalho B, Neto AP, Capela L, Teixeira C, Fareleira A, Devezas V, Macedo G, Preto J, Barbosa J, Baptista M, Pinto G, Damasceno M, Fougo JL, Costa-Maia J, Fernandes S, Carneiro F, Castedo S, Oliveira C
Genetic counselling in hereditary diffuse gastric cancer: economical and psycho-social impact European journal of human genetics : EJHG 27:  864-864, 2019. [Meeting Abstract] 
11. Korsak B, Almeida GM, Rocha S, Pereira C, Mendes N, Osório H, Pereira PMR, Rodrigues JMM, Schneider RJ, Sarmento B, Tomé JPC, Oliveira C
Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer. International journal of cancer 141: 1478-1489, 2017. [Article] 
 doi: 10.1002/ijc.30844 PMID: 28639285.
12. Oliveira P, Carvalho J, Rocha S, Azevedo M, Reis I, Camilo V, Sousa B, Valente S, Paredes J, Almeida R, Huntsman D, Oliveira C
 doi: 10.1038/srep34860 PMID: 27721458.
KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity. Virchows Archiv : an international journal of pathology 467: 383-92, 2015. [Article] 
Hereditary cancer risk assessment: challenges for the next-gen sequencing era. Frontiers in oncology 5: 62, 2015. [Editorial Material] 
Extracellular Vesicles - Powerful Markers of Cancer EVolution. Frontiers in immunology 5: 685, 2014. [Editorial Material] 
16. Bordeira-Carriço R, Ferreira D, Mateus DD, Pinheiro H, Pêgo AP, Santos MA, Oliveira C
Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA. European journal of human genetics : EJHG 22: 1085-92, 2014. [Article] 
17. Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C
Somatic mutations and deletions of the e-cadherin gene predict poor survival of patients with gastric cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31: 868-75, 2013. [Article] 
18. Carvalho J, van Grieken NC, Pereira PM, Sousa S, Tijssen M, Buffart TE, Diosdado B, Grabsch H, Santos MA, Meijer G, Seruca R, Carvalho B, Oliveira C
 doi: 10.1002/path.4032 PMID: 22450781.
19. Pinho SS, Oliveira P, Cabral J, Carvalho S, Huntsman D, Gärtner F, Seruca R, Reis CA, Oliveira C
20. Bordeira-Carriço R, Pêgo AP, Santos M, Oliveira C
Cancer syndromes and therapy by stop-codon readthrough. Trends in molecular medicine 18: 667-78, 2012. [Review] 
21. Pinheiro H, Carvalho J, Oliveira P, Ferreira D, Pinto MT, Osório H, Licastro D, Bordeira-Carriço R, Jordan P, Lazarevic D, Sanges R, Stupka E, Huntsman D, Seruca R, Oliveira C
 doi: 10.1093/hmg/dds248 PMID: 22752307.
22. Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, Dwerryhouse S, Caldas C, Linkage Consortium International Gastric Cancer
23. Pinheiro H, Bordeira-Carriço R, Seixas S, Carvalho J, Senz J, Oliveira P, Inácio P, Gusmão L, Rocha J, Huntsman D, Seruca R, Oliveira C
Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. Human molecular genetics 19: 943-52, 2010. [Article] 
 doi: 10.1093/hmg/ddp537. PMID: 19965908.
24. Karam R, Carvalho J, Bruno I, Graziadio C, Senz J, Huntsman D, Carneiro F, Seruca R, Wilkinson MF, Oliveira C
 doi: 10.1038/onc.2008.62 PMID: 18427545.
Different types of epithelial cadherin alterations play different roles in human carcinogenesis. Advances in anatomic pathology 9: 329-37, 2002. [Article] 
 PMID: 12409641.
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