Arnaud Paula
Name: Arnaud Paula
Academic Degree: PhD

Arnaud Paula
Arnaud Paula
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Assistant Researcher of Cancer Signalling & Metabolism

Short CV

I completed my Bachelor of Science in Genetics and Biotechnology in 2008, and my Masters degree in Evolutive and Molecular Genetics in 2010 by the University of Tras-os-Montes and Alto Douro. I got my PhD fellowship in 2011 and completed my PhD in Pathology and Molecular Genetics in 2016. During that time, I received the best poster award at the IV Congress of Clinical Research in 2012 and had the chance to join the laboratory of Dr. Jorge Reis-Filho from January 2014 to July 2014 at Memorial Sloan-Kettering Cancer Center (MSKCC), New York. The molecular and single-cell work I developed in that laboratory has allowed me to be part of two main projects involving the discovery of PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary gland published in Nature Genetics in 2014, and the single-cell work applied to formalin-fixed paraffin embedded breast tissues that was published in Nature Medicine in 2017. All the research work done as a PhD student have culminated in 4 first author articles and 5 articles as a contributing author. After having completed my PhD, I re-joined the laboratory of Dr. Jorge Reis-Filho and Dr. Britta Weigelt at MSKCC as a Post-doctoral Fellow for three years (2017-2020). Their laboratory aims to bring together traditional pathological techniques with genetic analysis and functional studies to refine the classification of gynecologic cancers and to identify novel drivers and potential therapeutic targets of specific tumor types. In fact and during that time, I mainly focused on the use of high-throughput genomics to identify drivers of rare gynecologic cancer types and acquired bioinformatics skills that allowed me to accurately interpret DNA and RNA sequencing data. I presented numerous scientific posters in national and international scientific congresses and meetings, and I also presented one of my work through an oral presentation at the International Gynecologic Cancer Society in 2019, Rio de Janeiro, Brasil, regarding the genetic analysis of primary and recurrent adult granulosa cell tumors of the ovary. I also led several projects that have culminated in several scientific articles related to the clinical and biological significance of intra-tumor phenotypic and genetic heterogeneity in cancer. Still in the same laboratory, I pursued my career as a Research Associate (2020-2022) and became an expert in single-cell DNA and RNA sequencing. I recently got a six year grant from the Foundation for Science and Technology (2023-2029) as an Assistant Researcher at i3S and in the group of Cancer Signaling and Metabolism, with the aim of identifying the molecular and functional changes associated with the occurrence of familial non-medullary thyroid carcinomas and to address specific cancer risks in patients and relatives, through a complete study of a co-segregation model between rare and common genetic alterations. All the research work I have developed to date has allowed me to be an author of 84 scientific articles (several in high impact journals), of which I am first or co-first author of 20 articles, and to have an h-index of 28. Besides this, I was responsible for supervising all of the research projects conducted in the laboratory at MSKCC as well as supervising master and PhD students. I interacted with 400 collaborators in co-authoring scientific works.


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