Ipatimup

RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH

Patrícia Carneiro

Name: Patrícia Carneiro

E-mail: pcarneiro@ipatimup.pt

Patrícia Carneiro

Member of

Junior Researcher of Epithelial Interactions in Cancer

Short CV

Patrícia Carneiro (PC) holds a PhD in Biomedical Sciences from Instituto de Ciências Biomédicas Abel Salazar, University of Porto, and is a Project Manager at the Epithelial Interactions in Cancer group, IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto/ I3S-Institute for Investigation and Innovation in Health, in the context of Porto. Comprehensive Cancer Centre. Previously she completed her Master in Biology and Biological Sciences in 2002 at Washington University in Saint Louis and her Bachelor in BSc. Human Genetics in 1998 at University of Leeds, School of Biomedical Sciences. Since 2012, PC has been devoted to understand the mechanisms of epithelial cell invasion in the EPIC group, at IPATIMUP/i3S. In this context, she has identified key molecules associated to cancer cell invasion and E-cadherin dysfunction. PC has 22 publications in international peer-reviewed journals (7 as first-author) with an h-index 11. Further, PC has attended 22 national/international meetings (4 oral presentations) and has participated in outreach activities organized by the institutions where she has worked.

Highlights

Germline mutations in tumor suppressor genes (TSGs) predispose to hereditary cancer. Despite that mutations are constitutionally present, cancer only occurs in specific tissues. This is the case for CDH1 germline mutation in hereditary diffuse gastric cancer syndrome (HDGC), where carriage of the abnormal CDH1 gene confers more than 80% lifetime risk to specifically develop gastric cancer.
What is not yet known in HDGC is the tissue specific molecular determinants behind the predominant increased risk for stomach cancer although E-cadherin is expressed in all epithelial tissues. We hypothesise that only gastric cells are able to overcome apoptosis mediated by E-cadherin biallelic inactivation and thus become more prone to acquire de novo alterations and at higher risk for transformation.
Our project aims to identify the gastric-specific gene expression profile that allows stomach epithelial cells to resist apoptosis induced by E-cadherin loss.

First Author

1. Carneiro P, Moreira AM, Figueiredo J, Barros R, Oliveira P, Fernandes MS, Ferro A, Almeida R, Oliveira C, Carneiro F, Schmitt F, Paredes J, Velho S, Seruca R

S100P is a molecular determinant of E-cadherin function in gastric cancer. Cell communication and signaling : CCS 17: 155, 2019. [Article]

doi: 10.1186/s12964-019-0465-9 PMID: 31767037.

4.3

2. Carneiro P, Figueiredo J, Bordeira-Carriço R, Fernandes MS, Carvalho J, Oliveira C, Seruca R

Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. Expert opinion on therapeutic targets 17: 1187-201, 2013. [Review]

doi: 10.1517/14728222.2013.827174 PMID: 23957294.

4.9

3. Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, Pinheiro H, Leite M, Melo S, Oliveira P, Simões-Correia J, Oliveira MJ, Carneiro F, Figueiredo C, Paredes J, Oliveira C, Seruca R

E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions. FEBS letters 586: 2981-9, 2012. [Review]

doi: 10.1016/j.febslet.2012.07.045 PMID: 22841718.

3.6

@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto