RESEARCHDIAGNOSTICSTRANSLATIONOUTREACH
 
Celso Reis
Name: Celso Reis
E-mail: celsor@ipatimup.pt
Extension: 
225570700
Academic Degree: Doctor of philosophy


Celso Reis
Celso Reis
Member of
Coordinator Researcher of Glycobiology in Cancer
Coordinator Researcher of Proteomics


Short CV
Celso A. Reis is the Head of the Glycobiology in Cancer group at i3S/Ipatimup, University of Porto, where he leads an international multidisciplinary team working on the Glycobiology in human diseases with focus on Cancer. He has published 186 peer-reviewed papers, with over 10100 citations and with H-index of 48 (Scopus). His publications include papers in journals such as: Cancer Cell, Nature Cell Biology, Glycobiology, Glycoconjugate Journal, International Journal of Cancer, Cancer Research, PNAS, JBC, JACS, BBA, FEBS Lett, Molecular Cellular Proteomics, Journal of Proteomics Oncogene, Cancer Letters, Mucosal Immunology, Cellular Immunology, Journal Clinical Investigation, Nature Reviews in Cancer, among others.

Celso A. Reis research focus on the role of glycosylation in human cancer. He has addressed the molecular mechanisms controlling glycosylation in cancer cell biology, more specifically the role of glycosyltransferases regulating the biosynthesis of glycans in cancer. These included the role of sialyltransferases leading to the biosynthesis of terminal sialylated glycan antigens expressed by cancer cells, such as ST6GalNAc determining the aberrant expression of the simple O-glycan Sialyl-Tn antigen, and the ST3Gal-transferases and Fucosyltransferases controlling the expression of sialyl-Lewis antigens.

Celso A. Reis has contributed for determining the role of these glycosylation modifications, including O-glycans and N-Glycans and the consequences to gastrointestinal cancer cell biology, including the mechanisms regulating cancer invasion, metastasis and tumour glycoimmunology. CR has also addressed the application of glycoconjugates as biomarkers in human cancer and pre-neoplastic lesions, and the application of novel unique monoclonal antibodies to clinical samples, currently in the market.

Currently, Celso A. Reis develops novel strategies to detect and characterize cancer, in order to be able to improve cancer treatment based on the identification of the key glycans controlling cancer cell communication, glycans that can be used as markers for cancer patient stratification, as well as glycans and glycoconjugate that can be used as novel targets in therapy.

Highlights
Celso A. Reis has published 186 peer-reviewed papers, with over 10100 citations and with H-index of 48 (Scopus). His publications include papers in journals such as: Cancer Cell, Nature Cell Biology, Glycobiology, Glycoconjugate Journal, International Journal of Cancer, Cancer Research, PNAS, JBC, JACS, BBA, FEBS Lett, Molecular Cellular Proteomics, Journal of Proteomics Oncogene, Cancer Letters, Mucosal Immunology, Cellular Immunology, Journal Clinical Investigation, Nature Reviews in Cancer, among others. He has contributed with various patents and novel unique monoclonal antibodies targeting glycoproteins that are currently in the market for application in clinical samples.

Supervisor of
Álvaro Martins, Young Researcher (Msc)
Ana Magalhães, Junior Researcher
António Polónia, Researcher
Beatriz Leão, Visiting Researcher
Catarina Gomes, Junior Researcher
Daniela Freitas, Junior Researcher
Filipe Pinto, Post Doc
Francisca Diniz, PhD Student
Henrique Duarte, Fellow
Hugo Miguel Teixeira Ferraz dos Santos Sousa, Research Consultant
Irina Amorim, Researcher
Isabel Mesquita, Visiting Researcher
Joana Rodrigues, PhD Student
Joana Gomes, Junior Researcher
Lucia Sanjurjo, Visiting Researcher
Rafaela Abrantes, Fellow

PI (running)
"Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases – a system analysis NETwork towards precision medicine (DOCnet)"
"GastroCure .: GastroCure - Extratos bioativos de soja e vegetais crucíferos para aplicação em distúrbios gastrointestinais: desenvolvimento, caracterização e libertação"
"GLYCANTIGENS .: Glicoantigénios da proteina MUC1: Um perspectiva estructural na luta contra o cancro"
"Passive immunotherapy against gastric cancer"

PI (closed)
"Glicoengenharia celular para a avaliação das modificações pós-traducionais dos receptores celulares no cancro"
"Glycosylation of tyrosine kinase receptors as novel biomarkers for targeted therapy."
"Gycosylation alterations in cancer cell invasion and metastasis."
"GlycoModels: 3D glyco-engineered models to address the role of glycosylation in gastric cancer clinical management"
"Human Extracellular Target Validation of HS Members"
"Initial Training Network - Systems Glycobiology of Gastric Cancer."
Apoio da Fundação "Glicosilação de recetores em cancro gástrico: novos biomarcadores para uma terapia direcionada"
"Glycosylation of cellular receptors in Cancer."
"Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells."
"PYLORICIDAL - Engineered biomaterials with Helicobacter PYLORI bacteriCIDAL effect"
"Glycomic Approach to unravel the role of Glycostructures in Gastric Carcinogenesis"
"Programa de Acções Integradas Luso-Francesas PAULIF2011"
"Early detection of cancer using serum biomarkers based on aberrant post-translational modifications of O-glycoproteins, O-PTM-Biomarkers"
"Manutenção, caracterização e comercialização dos anticorpos monoclonais para mucinas"
"A strategy for preventing H.pylori-associated gastric cancer based on materials with specific receptors to the bacterin-form SAMS to Gly-R chitosan microspheses"
Programa Nacional de Reequipamento científico
"Molecular mechanisms of biosynthesis of sialylated cancer-associated mucin carbohydrate antigens in gastric carcinoma"
"Identification of Glycosylation-associated genes induced by Helicobacter pylori in gastric cells: a glycomic approach."
First Author
 
C
IF
1. Reis C
Cellular glycosylation: biosynthesis and functional implications in cancer Febs Open Bio 9: 60-61, 2019. [Meeting Abstract] 
.
 
0
2.0 (*)
2. Madeira PP, Reis CA, Rodrigues AE, Mikheeva LM, Chait A, Zaslavsky BY
Solvent properties governing protein partitioning in polymer/polymer aqueous two-phase systems. Journal of chromatography. A 1218: 1379-84, 2011. [Article] 
 doi: 10.1016/j.chroma.2011.01.020 PMID: 21288530.
 
43
4.5
3. Reis CA, Campos D, Osório H, Santos LL
Glycopeptide microarray for autoantibody detection in cancer. Expert review of proteomics 8: 435-7, 2011. [Review] 
 doi: 10.1586/epr.11.30 PMID: 21819298.
 
12
3.7
4. Reis CA, Osorio H, Silva L, Gomes C, David L
Alterations in glycosylation as biomarkers for cancer detection. Journal of clinical pathology 63: 322-9, 2010. [Review] 
 doi: 10.1136/jcp.2009.071035 PMID: 20354203.
 
262
2.5
5. Reis C, Lopes JM, Carneiro E, Vilarinho A, Portugal R, Duarte F, Fonseca J
Temporal giant cell reparative granuloma: a reappraisal of pathology and imaging features. AJNR. American journal of neuroradiology 27: 1660-2, 2006. [Article] 
 PMID: 16971609.
 
9
2.3
6. Reis CA, Teixeira A, David L
Role of mucins in Helicobacter pylori adhesion to the gastric mucosa. Helicobacter 9: 181; author reply 181-2, 2004. [Letter] 
 doi: 10.1111/j.1083-4389.2004.00216.x PMID: 15068421.
 
0
2.3
7. Reis CA, David L, Carvalho F, Mandel U, de Bolós C, Mirgorodskaya E, Clausen H, Sobrinho-Simões M
Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 48: 377-88, 2000. [Article] 
 PMID: 10681391.
 
120
2.6
8. Reis CA, David L, Correa P, Carneiro F, de Bolós C, Garcia E, Mandel U, Clausen H, Sobrinho-Simões M
Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer research 59: 1003-7, 1999. [Article] 
 PMID: 10070955.
 
269
8.6
9. Reis CA, David L, Seixas M, Burchell J, Sobrinho-Simões M
Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma. International journal of cancer 79: 402-10, 1998. [Article] 
 PMID: 9699534.
 
97
3.3
10. Reis CA, Sørensen T, Mandel U, David L, Mirgorodskaya E, Roepstorff P, Kihlberg J, Hansen JE, Clausen H
Development and characterization of an antibody directed to an alpha-N-acetyl-D-galactosamine glycosylated MUC2 peptide. Glycoconjugate journal 15: 51-62, 1998. [Article] 
 PMID: 9530956.
 
58
2.2
11. Reis CA, Hassan H, Bennett EP, Clausen H
Characterization of a panel of monoclonal antibodies using GalNAc glycosylated peptides and recombinant MUC1. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 19 Suppl 1: 127-33, 1998. [Article; Proceedings Paper] 
 PMID: 9422098.
 
8
1.6
12. Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, Sobrinho-Simões M
Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody. International journal of cancer 74: 112-21, 1997. [Article] 
 PMID: 9036879.
 
161
3.4
Senior Author
 
C
IF
1. Mereiter S, Balmaña M, Campos D, Gomes J, Reis CA
Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading? Cancer cell 36: 6-16, 2019. [Review] 
 doi: 10.1016/j.ccell.2019.06.006 PMID: 31287993.
 
6
23.9 (*)
2. Mereiter S, Martins ÁM, Gomes C, Balmaña M, Macedo JA, Polom K, Roviello F, Magalhães A, Reis CA
O-glycan truncation enhances cancer-related functions of CD44 in gastric cancer. FEBS letters 593: 1675-1689, 2019. [Article; Proceedings Paper] 
 doi: 10.1002/1873-3468.13432 PMID: 31077346.
 
3
2.7 (*)
3. Freitas D, Balmaña M, Poças J, Campos D, Osório H, Konstantinidi A, Vakhrushev SY, Magalhães A, Reis CA
Different isolation approaches lead to diverse glycosylated extracellular vesicle populations. Journal of extracellular vesicles 8: 1621131, 2019. [Article] 
 doi: 10.1080/20013078.2019.1621131 PMID: 31236201.
 
3
11.0 (*)
4. Freitas D, Campos D, Gomes J, Pinto F, Macedo JA, Matos R, Mereiter S, Pinto MT, Polónia A, Gartner F, Magalhães A, Reis CA
O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype. EBioMedicine 40: 349-362, 2019. [Article] 
 doi: 10.1016/j.ebiom.2019.01.017 PMID: 30662000.
 
1
6.7 (*)
5. Reis C
Cellular glycosylation: biosynthesis and functional implications in cancer Febs Open Bio 9: 60-61, 2019. [Meeting Abstract] 
.
 
0
2.0 (*)
6. Gomes C, Almeida A, Barreira A, Calheiros J, Pinto F, Abrantes R, Costa A, Polonia A, Campos D, Osório H, Sousa H, Pinto-de-Sousa J, Kolarich D, Reis CA
Carcinoembryonic antigen carrying SLeX as a new biomarker of more aggressive gastric carcinomas. Theranostics 9: 7431-7446, 2019. [Article] 
 doi: 10.7150/thno.33858 PMID: 31695778.
 
0
8.1 (*)
7. Duarte HO, Gomes J, Machado JC, Reis CA
Gastric cancer: Basic aspects. Helicobacter 23 Suppl 1: e12523, 2018. [Article; Proceedings Paper] 
 doi: 10.1111/hel.12523 PMID: 30277636.
 
8
4.1 (*)
8. Mereiter S, Polom K, Williams C, Polonia A, Guergova-Kuras M, Karlsson NG, Roviello F, Magalhães A, Reis CA
The Thomsen-Friedenreich Antigen: A Highly Sensitive and Specific Predictor of Microsatellite Instability in Gastric Cancer. Journal of clinical medicine 7: ., 2018. [Article] 
 doi: 10.3390/jcm7090256 PMID: 30189652.
 
4
5.6 (*)
9. Balmaña M, Mereiter S, Diniz F, Feijão T, Barrias CC, Reis CA
Multicellular Human Gastric-Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas. Molecules (Basel, Switzerland) 23: ., 2018. [Article] 
 doi: 10.3390/molecules23112815 PMID: 30380716.
 
2
3.1 (*)
10. Magalhães A, Duarte HO, Reis CA
Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis. Cancer cell 31: 733-735, 2017. [Editorial Material] 
 doi: 10.1016/j.ccell.2017.05.012 PMID: 28609653.
 
24
22.8
11. Ferreira JA, Magalhães A, Gomes J, Peixoto A, Gaiteiro C, Fernandes E, Santos LL, Reis CA
Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics. Cancer letters 387: 32-45, 2017. [Review] 
 doi: 10.1016/j.canlet.2016.01.044 PMID: 26828132.
 
22
6.5
12. Duarte HO, Balmaña M, Mereiter S, Osório H, Gomes J, Reis CA
Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor. International journal of molecular sciences 18: ., 2017. [Article] 
 doi: 10.3390/ijms18112262 PMID: 29143776.
 
6
3.7
13. Gomes J, Mereiter S, Magalhães A, Reis CA
Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries. Cancer cell 32: 544-545, 2017. [Editorial Material] 
 doi: 10.1016/j.ccell.2017.10.010 PMID: 29136499.
 
4
22.8
14. Mereiter S, Balmaña M, Gomes J, Magalhães A, Reis CA
Glycomic Approaches for the Discovery of Targets in Gastrointestinal Cancer. Frontiers in oncology 6: 55, 2016. [Review] 
 doi: 10.3389/fonc.2016.00055 PMID: 27014630.
 
24
-
15. Mereiter S, Magalhães A, Adamczyk B, Jin C, Almeida A, Drici L, Ibáñez-Vea M, Gomes C, Ferreira JA, Afonso LP, Santos LL, Larsen MR, Kolarich D, Karlsson NG, Reis CA
Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer. Biochimica et biophysica acta 1860: 1795-808, 2016. [Article] 
 doi: 10.1016/j.bbagen.2015.12.016 PMID: 26721331.
 
23
4.7
16. Magalhães A, Rossez Y, Robbe-Masselot C, Maes E, Gomes J, Shevtsova A, Bugaytsova J, Borén T, Reis CA
Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding. Scientific reports 6: 25575, 2016. [Article] 
 doi: 10.1038/srep25575 PMID: 27161092.
 
14
4.3
17. Duarte HO, Freitas D, Gomes C, Gomes J, Magalhães A, Reis CA
Mucin-Type O-Glycosylation in Gastric Carcinogenesis. Biomolecules 6: 1, 2016. [Review] 
 doi: 10.3390/biom6030033 PMID: 27409642.
 
8
-
18. Mereiter S, Magalhães A, Adamczyk B, Jin C, Almeida A, Drici L, Ibáñez-Vea M, Larsen MR, Kolarich D, Karlsson NG, Reis CA
Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4. Data in brief 7: 814-33, 2016. [Article; Data Paper] 
 doi: 10.1016/j.dib.2016.03.022 PMID: 27077082.
 
4
-
19. Magalhães A, Mereiter S, Reis C
Reciprocal Modulation of Terminal Sialylation and Bisecting N-Glycans: A New Axis of Cancer-Cell Glycome Regulation? The Journal of biological chemistry 291: 8308, 2016. [Letter] 
 doi: 10.1074/jbc.L116.722462 PMID: 27060175.
 
3
4.1
20. Pinho SS, Reis CA
Glycosylation in cancer: mechanisms and clinical implications. Nature reviews. Cancer 15: 540-55, 2015. [Review] 
 doi: 10.1038/nrc3982 PMID: 26289314.
 
665
34.2
21. Campos D, Freitas D, Gomes J, Magalhães A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA
Probing the o-glycoproteome of gastric cancer cell lines for biomarker discovery. Molecular & cellular proteomics : MCP 14: 1616-29, 2015. [Article] 
 doi: 10.1074/mcp.M114.046862 PMID: 25813380.
 
36
5.9
22. Magalhães A, Marcos-Pinto R, Nairn AV, Dela Rosa M, Ferreira RM, Junqueira-Neto S, Freitas D, Gomes J, Oliveira P, Santos MR, Marcos NT, Xiaogang W, Figueiredo C, Oliveira C, Dinis-Ribeiro M, Carneiro F, Moremen KW, David L, Reis CA
Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852: 1928-39, 2015. [Article] 
 doi: 10.1016/j.bbadis.2015.07.001 PMID: 26144047.
 
25
5.2
23. Campos D, Freitas D, Gomes J, Reis CA
Glycoengineered cell models for the characterization of cancer O-glycoproteome: an innovative strategy for biomarker discovery. Expert review of proteomics 12: 337-42, 2015. [Review] 
 doi: 10.1586/14789450.2015.1059758 PMID: 26098314.
 
6
3.5
24. Pinho SS, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhães A, Gärtner F, Mendonfa AM, Isaji T, Gu J, Carneiro F, Seruca R, Taniguchi N, Reis CA
E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V. Biochimica et biophysica acta 1830: 2690-700, 2013. [Article] 
 PMID: 23671930.
 
64
3.8
25. Pinho SS, Carvalho S, Marcos-Pinto R, Magalhães A, Oliveira C, Gu J, Dinis-Ribeiro M, Carneiro F, Seruca R, Reis CA
Gastric cancer: adding glycosylation to the equation. Trends in molecular medicine 19: 664-76, 2013. [Review] 
 doi: 10.1016/j.molmed.2013.07.003 PMID: 23932995.
 
59
10.1
26. Gomes C, Osório H, Pinto MT, Campos D, Oliveira MJ, Reis CA
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells. PloS one 8: e66737, 2013. [Article] 
 doi: 10.1371/journal.pone.0066737 PMID: 23799130.
 
44
3.5
27. Gomes J, Reis CA
Immunodetection of glycosyltransferases in gastrointestinal tissues. Methods in molecular biology (Clifton, N.J.) 1022: 349-56, 2013. [] 
 doi: 10.1007/978-1-62703-465-4_26 PMID: 23765674.
 
0
-
28. Osório H, Reis CA
Mass spectrometry methods for studying glycosylation in cancer. Methods in molecular biology (Clifton, N.J.) 1007: 301-16, 2013. [] 
 doi: 10.1007/978-1-62703-392-3_13 PMID: 23666732.
 
0
-
29. Gomes J, Magalhães A, Carvalho AS, Hernandez GE, Papp SL, Head SR, Michel V, David L, Gärtner F, Touati E, Reis CA
Glycophenotypic Alterations Induced by Pteridium aquilinum in Mice Gastric Mucosa: Synergistic Effect with Helicobacter pylori Infection. PloS one 7: e38353, 2012. [Article] 
 doi: 10.1371/journal.pone.0038353 PMID: 22719879.
 
0
3.7
30. Pinho SS, Seruca R, Gärtner F, Yamaguchi Y, Gu J, Taniguchi N, Reis CA
Modulation of E-cadherin function and dysfunction by N-glycosylation. Cellular and molecular life sciences : CMLS 68: 1011-20, 2011. [Review] 
 doi: 10.1007/s00018-010-0595-0 PMID: 21104290.
 
88
6.6
31. Marcos NT, Bennett EP, Gomes J, Magalhaes A, Gomes C, David L, Dar I, Jeanneau C, Defrees S, Krustrup D, Vogel LK, Kure EH, Burchell J, Taylor-Papadimitriou J, Clausen H, Mandel U, Reis CA
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues. Frontiers in bioscience (Elite edition) 3: 1443-55, 2011. [] 
 PMID: 21622148.
 
0
-
32. Carvalho AS, Harduin-Lepers A, Magalhães A, Machado E, Mendes N, Costa LT, Matthiesen R, Almeida R, Costa J, Reis CA
Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells. The international journal of biochemistry & cell biology 42: 80-9, 2010. [Article] 
 doi: 10.1016/j.biocel.2009.09.010 PMID: 19781661.
 
61
5.0
33. Magalhães A, Reis CA
Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 43: 611-8, 2010. [Review] 
 PMID: 20521012.
 
45
1.2
34. Magalhães A, Ismail MN, Reis CA
Sweet receptors mediate the adhesion of the gastric pathogen Helicobacter pylori: glycoproteomic strategies. Expert review of proteomics 7: 307-10, 2010. [Editorial Material] 
 doi: 10.1586/epr.10.18 PMID: 20536299.
 
12
4.4
35. Magalhães A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osório H, David L, Le Pendu J, Haas R, Dell A, Borén T, Reis CA
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa. Glycobiology 19: 1525-36, 2009. [Article] 
 doi: 10.1093/glycob/cwp131 PMID: 19706747.
 
60
4.4 (*)
36. Pinho SS, Osório H, Nita-Lazar M, Gomes J, Lopes C, Gärtner F, Reis CA
Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochemical and biophysical research communications 379: 1091-6, 2009. [Article] 
 doi: 10.1016/j.bbrc.2009.01.024 PMID: 19159617.
 
50
2.6 (*)
37. Gomes J, Marcos NT, Berois N, Osinaga E, Magalhães A, Pinto-de-Sousa J, Almeida R, Gärtner F, Reis CA
Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 57: 79-86, 2009. [Article] 
 doi: 10.1369/jhc.2008.952283 PMID: 18854599.
 
42
2.8 (*)
38. Magalhães A, Marcos N T, Carvalho A S, David L, Figueiredo C, Bastos J, David G, Reis C
Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells FEMS immunology and medical microbiology I: 1-10, 2009. [Article] 
 doi: 10.1111/j.1574-695X.2009.00569.x PMID: 19519784.
 
9
2.3
39. Gomes J, Michel V, Magalhaes A, Ovesen RG, Hansen HH, Gartner F, Touati E, Reis CA
Biologic Role of Pteridium aquilinum in Gastric Epithelial Cells: Potential Synergistic Effect with H. pylori Infection Helicobacter 14: 378-378, 2009. [Meeting Abstract] 
.
 
0
2.9
40. Marcos NT, Magalhães A, Ferreira B, Oliveira MJ, Carvalho AS, Mendes N, Gilmartin T, Head SR, Figueiredo C, David L, Santos-Silva F, Reis CA
Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x. The Journal of clinical investigation 118: 2325-36, 2008. [Article] 
 doi: 10.1172/JCI34324 PMID: 18483624.
 
79
16.6
41. Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA
Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells. Cancer letters 249: 157-70, 2007. [Article] 
 doi: 10.1016/j.canlet.2006.08.010 PMID: 16965854.
 
87
3.4
42. Ferreira B, Marcos NT, David L, Nakayama J, Reis CA
Terminal alpha1,4-linked N-acetylglucosamine in Helicobacter pylori-associated intestinal metaplasia of the human stomach and gastric carcinoma cell lines. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 54: 585-91, 2006. [Article] 
 doi: 10.1369/jhc.5A6836.2006 PMID: 16618943.
 
23
2.4
43. Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen. Cancer research 64: 7050-7, 2004. [Article] 
 doi: 10.1158/0008-5472.CAN-04-1921 PMID: 15466199.
 
125
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@ 2014 Ipatimup Institute of Molecular Pathology and Immunology of the University of Porto
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