Jorge Lima
Name: Jorge Lima
Academic Degree: Doctor of philosophy

Jorge Lima
Jorge Lima
Member of
Advisory Board Member of Ipatimup Innovation
Consultant of Ipatimup Diagnostics

Short CV
I am a currently a Researcher at Ipatimup, where I have been mainly dedicated to the study of cancer metabolism. I hold an undergraduate degree in Biology and a PhD from the Medical Faculty of University of Porto. My doctoral research focused on the role of metabolic enzymes in inherited neoplasias. As a post-doc, I started building cell line models for mitochondrial deficiency, in collaboration between Ipatimup and the Roswell Park Cancer Institute, Buffalo, USA. Over the years I have also developed collaborations at the clinical level, particularly with the University Hospital and the Oncology Institute in Porto. I have supervised two Master students to completion and I am currently supervising two Master students, one PhD student and co-supervising one PhD student. My scientific research has resulted in over 20 publications in peer-reviewed international journals, that have given rise to 774 citations (741 without self-citation; h-index 11; source: Web of Science). I am currently also part of the Translational Research Unit at Ipatimup, where we aim to capitalize the scientific expertise at Ipatimup and to develop collaborations and strategic alliances with Pharma and Biotech companies.

My main area of research is the metabolic reprogramming of cancer cells and how this may contribute to cancer development. My interest in this subject came from previous studies on the particular features of the so-called Hürthle cell thyroid tumours which accumulate large amounts of abnormal mitochondria in the cytoplasm; these tumours were found to harbor somatic mutations in the mitochondrial DNA that presumably result in loss of function of the oxidative phosphorylation system (OXPHOS). In subsequent studies I have addressed the role of the nuclear-encoded mitochondrial enzyme succinate dehydrogenase (SDH) in the development of peripheral nervous system tumours such as paragangliomas (PGL) and pheochromocytomas (PCC), as well as the development of medullary thyroid tumours. The presence of germline loss-of-function mutations in SDH (Krebs cycle enzyme) subunits in inherited PGL and PCC reveals that altered cell metabolism is capable of inducing tumour development

Supervisor of
Joana Nunes, PhD Student
Joana Peixoto, PhD Student
Maria João Ramalho, Visiting Researcher

PI (running)

PI (closed)
First Author
1. Celestino R, Lima J, Faustino A, Máximo V, Gouveia A, Vinagre J, Soares P, Lopes JM
2. Lima J, Feijão T, Ferreira da Silva A, Pereira-Castro I, Fernandez-Ballester G, Máximo V, Herrero A, Serrano L, Sobrinho-Simões M, Garcia-Rostan G
3. Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M
4. Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M
BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. The Journal of clinical endocrinology and metabolism 89: 4267-71, 2004. [Article] 
Germline succinate dehydrogenase subunit D mutation segregating with familial non-RET C cell hyperplasia. The Journal of clinical endocrinology and metabolism 88: 4932-7, 2003. [Article] 
 PMID: 14557476.
Alterations of the SDHD gene locus in midgut carcinoids. Genes, chromosomes & cancer 36: 424, 2003. [Letter] 
 doi: 10.1002/gcc.10147 PMID: 12619155.
7. Lima J, Máximo V, Soares P, Williams D, Bogdanova T, Thomas GA, Sobrinho-Simões M
Senior Author
Metabolic traits of cancer stem cells. Disease models & mechanisms 11: ., 2018. [Review] 
 doi: 10.1242/dmm.033464 PMID: 29991569.
2. Batista R, Cruvinel-Carloni A, Vinagre J, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, de Almeida GC, Matsushita MM, Clara C, Neder L, Viana-Pereira M, Honavar M, Castro L, Lopes JM, Carvalho B, Vaz RM, Máximo V, Soares P, Sobrinho-Simões M, Reis RM, Lima J
 doi: 10.1002/ijc.30057 PMID: 26914704.
3. Amorim-Pires D, Peixoto J, Lima J
Hypoxia Pathway Mutations in Pheochromocytomas and Paragangliomas. Cytogenetic and genome research 150: 227-241, 2016. [Review] 
 doi: 10.1159/000457479 PMID: 28231563.
4. Nunes JB, Peixoto J, Soares P, Maximo V, Carvalho S, Pinho SS, Vieira AF, Paredes J, Rego AC, Ferreira IL, Gomez-Lazaro M, Sobrinho-Simoes M, Singh KK, Lima J
 doi: 10.1093/hmg/ddu612 PMID: 25504047.
5. Martins RG, Nunes JB, Máximo V, Soares P, Peixoto J, Catarino T, Rito T, Soares P, Pereira L, Sobrinho-Simões M, Santos AP, Couto J, Henrique R, Matos-Loureiro J, Dias P, Torres I, Lima J
A founder SDHB mutation in Portuguese paraganglioma patients. Endocrine-related cancer 20: L23-6, 2013. [Letter] 
 doi: 10.1530/ERC-12-0399 PMID: 24092654.
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